Previous Thread: >>35645729• Help, advice, guidance on meds and dosages• HRT related medical experiences and research• Availability and pricing of medications• Rational and scientific discussionSee following post for a pharmacy list.Survey: https://1drv.ms/xs/s!AudRJceTA5C9c2G5lCV2Avq0kQ0▶ Survey data: https://1drv.ms/x/s!AudRJceTA5C9cyIWo6_X14AvHyM▶ HRTGen Data Analysis: https://1drv.ms/f/s!AudRJceTA5C9gRLLWnbpdzlIxe4r▶ HRT Info Sheets: https://1drv.ms/f/s!AudRJceTA5C9gQnyM7wxZcBGWRzW▶ Pill ID: https://www.drugs.com/imprints.php▶ DrugBank: https://www.drugbank.com/▶ Basic HRT: https://apps.carleton.edu/campus/gsc/assets/hormones_MTF.pdf▶ HRT ranges: http://www.hemingways.org/GIDinfo/hrt_ref.htm▶ Powers Method: https://powersfamilymedicine.com/s/Healthcare-of-the-Transgender-Patient-V60.pptx▶ Endocrine Society Guidelines: https://academic.oup.com/jcem/article/102/11/3869/4157558▶ Transline Guidelines (with bicalutamide): https://transline.zendesk.com/hc/en-us/article_attachments/360047702053/TransLine_HRT_Guidelines_FINAL.pdf▶ WPATH SOC: https://www.wpath.org/publications/soc▶ TransDIY: https://www.reddit.com/r/transDIY▶ Blood tests (US): https://www.privatemdlabs.com/, https://www.labsmd.com/▶ Blood tests (UK, Ireland): https://www.medichecks.com/▶ Blood tests (Canada Only): https://bloodtestscanada.com/▶ Blood tests (Sweden): https://werlabs.se/▶ Blood tests by mail: https://www.letsgetchecked.com/ DIY capillary blood samples. Expensive.▶ Lab test guide: https://www.healthcare.uiowa.edu
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>ERROR>YOU HAVE NO WOMB, PERIODS DO NOT COMPUTEROGER ROGER
>>35706018trans yourself immediately
>>35706066>I AM NOT SCHEDULED FOR DECOMMISSIONROGER ROGER
So what pills do I need to ask my doctor for to get sublingual as opposed to oral? Or is it even different?
>>35706287 i'd rather go for transdermal on scrotum if you don't want injections it doesn't matter whether it is unesterified, hemihydrate or valerate for sublingual, but some valerate brands pills might be made in a way making sublingual more tiresome. also valerate provides less estrogen per total mg because of ester tail also being included in it (estradiol hemihydrate/unesterified 0.76 mg = estradiol valerate 1 mg)
>>35706459Is transdermal gels? That looks interesting if it's just once per day. I do want to do injections but I would need to diy if I wanted them.
>>35706556yes
>>35705951My doctor wants to put me on 5mg of estradiol biweekly after she saw my levels were 650 pg/ml, am I being hondosed?
>>35706556you'll typically need twice a day. 2mg x2 seems to work for most people, but some may need up to 3mg x2. you'll need to adjust a bit with bloodwork as transderm absorption rates differ wildly between people.
got prescribed pills in addition to my usual stuff recently, 2 mg estradiol valerate, I'm aware that's a hondose, just got several questionscan I take it sublingually for better effect?how much longer after the official expiration date will they be good for?thinking of stockpiling them because my levels are good already
>>35707411>>357074111. yes2. so long as you keep in good conditions (cool dry no sunlight) probably 2-3 more years?
>>35705959>hrtgen2.png>estradiol patches >scrotumSo people are actually putting medicine on their balls regularly?
>>35707411>can I take it sublingually for better effect?sublingual/buccal is a bit of a meme, you end up swallowing most of the pill as it dissolves into your saliva>how much longer after the official expiration date will they be good for?Estradiol's stability depends on its storage conditions. It can degrade through oxidation, photodegradation, and hydrolysis. To maximize shelf life:- Store in a cool, dark, dry place.- Avoid oxygen exposure.- Use amber or opaque containers to block light.In ideal conditions, estradiol can remain stable for several years.>thinking of stockpilingwith imminent risk of regulatory changes in several countries this is a good ideathough consider before you invest in a stockpile the cost and storage volume efficiency of injectables versus pills
>>35707530I've got a patch on my scrotum right now. First time I put it there instead of on my tummy. To note: boobs hurt significantly more which can only be a good sign, patch adhered way better than i thought and doesnt come off at the edges like all my other patches ever, not sure about long term though because theres only like 2/3 patch locations on the scrotum and youre meant to rotate the sites, and lastly, patches are on shortage yet again so i guess its gg right after i finally unlock the secret of patches
>>35707660yeah I guess injectables would be the better option for stockpiling but they're not prescribed here and I'm a bit too paranoid about injecting stuff I ordered online into my bodymight look into homebrewing if things get worse, I know that's still stuff from the internet but I feel a bit more in control if that makes senseso I'd rather stockpile what I'm prescribed anywayso are estradiol valerate pills less taxing on circulation and liver compared to estradiol pills?
>>35708105>so are estradiol valerate pills less taxing on circulation and liver compared to estradiol pills?no
>>35707660but you got me interested, so how long can I safely store a vial of unopened EEn?last dumb question I promise
>>35708105>might look into homebrewing if things get worsei looked into homebrewing injections a few weeks ago and ultimately decided its unfeasible to do to a safe standard.
>>35708270yet somehow trannies don't massively land in hospitals after injecting bathtub troonshine
>>35705951im on 4mg ev every 4 days for ~20 days now. i read it's good to also be on an aa, should i still buy spiro or does it not matter anymore?
>>35708501spiro is trash, would be better off low dose bicalutamideif you will continue having androgenic symptoms like acne, then take bicalutamide
>>35708543thats expensive but ok i guess. still, is it worth it if i already startet monotherapy
>>35708657low dose is not expensive
>>35708207oil suspensions have better shelf life because the oil itself protects the estradiol ester from exposure to oxygenas long as you keep them in cool dark storage vials are shelf stable for a very long time
If I take ralox to stop breast tissue from growing further do I get to keep nipple sensitivity or no?
>>35708938very long time being what - 10 years?
>>35708987Here's an estimate and this explains the math i dont actually understandhttps://rentry.org/svzu3s83
>>35709127thank you that is informative, might switch to stockpiling een then
>0.15ml of ec once a week>400mg vial>Below average T levelsIs this an OK starting dose?Should I lower dose and increase more gradually?Yet to do bloods, would like to avoid cone shaped boobies
>>35709533I'm guessing it's 40mg per ml? Standard vanna vial
is 4 mg of ev every 4 days a lot..the simulator says the trough estradiol level is 300 pg/ml
>>35709783yes
How to calculate mg into ml?Am this anon>>35709533
>>3571001540 mg/mL:40 * x mL = dose in mgfor example, 40 * 0.15 ml = 6 mgthe calculator shows 400-300 pg/mL. it's fine. but it's based on statistics, some people get more estrogen per dose, some less. i get twice the simulated values.
>>35710060Is it genuinely fine or better to reduce dose and up more gradually?Would prefer slower but more rounded changes
weird question here but maybe someone has an answer. i’ve been on hrt for several years and for a while i’ve noticed translucent whiteish spots in my underwear. i’ve read before when i’ve looked stuff up about this that people claim it’s because of tissues reacting to estrogen the same way they would in cis women and producing lubricants. is that just hon science? i’ve never been able to find a reliable source that gives an explanation. does anybody have anything that gives an actual medical explanation for this?also, no it isn’t from me not being clean or from urine. it also can’t be because of sperm because i literally produce 0.
>>35710184Ur body has to keep everything moist down there inside of you and sometimes stuff leaks out it’s like wearing too much chapstick and it build up at edges of your mouth other shit is hon science
>>35710318ok but like, wtf is it? and why doesn’t it stay inside my body like it’s supposed to?
>>35710434It’s literally lubricant for your pee hole/tube so it doesn’t dryout and and crack it’s a sterile membrane too and should remain that way with the help of lubricant
>>35710434It happens it just does people just don’t talk about it cause it’s understood I’m detrans and I get it too and I’m basically sterile too
>>35710482jfc sorry i’m just curious about the science of it. my fault for asking a question and wondering if anyone could point me somewhere i could learn more
>>35710540Ur good really that’s just the answer not everything needs an explanation
need>A method for the synthesis of dimeric, trimeric and tetrameric estradiol esters is described. It is based on the esterification of the OH-groups of estradiol-17β or estradiol-17β-acetate with 3-acetoxy-estradiol-17β-hemisuccinate as carboxylic acid component in the presence of N, N'-carbonyldiimidazole. Preliminary biological tests have shown that these compounds possess a very protracted estrogenic activity when administered s.c. to the oophorectomized rat. A single injection of 40 μg/rat of the trimeric estradiol derivative e.g. brought about vaginal estrus for 120 days as compared to 80 days when estradiol undecylate was used.https://sci-hub.se/https://doi.org/10.1016/0039-128X(73)90072-X
hey whoresi got a pill crusher for my sublingual dose and ive crushed every dose for the past few days, and while im still within my first year of hrt i have noticed major breast soreness compared to days where i let the pill melt under my tonguesomeone smarter than me explain
>>35710885More rapid uptake EZ
>>35705951Can anyone share resources on how to begin homebrewing just in case? t. uk tranny ready to do it just to spite the government if they make buying illegal
>>35712507it's easier to simply buy raw estradiol powder in bulkhormones are difficult to manufacture especially as an individual with no equipment or experience
Does anyone know what causes this kind of e vial colorization and would it be still safe to use?
gaise do your saliva seem more smooth, perhaps shinier feeling, more viscous, after switching to injections / increasing dosage ?
nurse did a subcut injection with my prostap Leuprorelin anti-androgen, and 4 days later there's still a painful, hot lump.I've previously self administered them into my glutes and not had this issue in the past, maybe a dead leg sensation for a few days and some itching.Should I panic? Has she just sent me to an early grave?
>>35712738i think thats more or less what they plan to do. likely they want a guide on preparation of vials
is it possible to have a natural resistance to estrogen? i inject 8mg een into my thigh every week and my levels are 170 pgml at through.when i was on up to 12 mg sublingual pills i could never get above 60 pmgl (titrated up from 2 mg over 16 months). should i go up to 10 mg? it seems like the pattern is nothing will happen?
>>35713675it’s probably just irritation that you normally avoid by going im. if it stays for a week or two then maybe.
>>35713863i'd imagine it would be impossible to keep the oil solution sterile if you made it yourself. maybe heating it to destroy germs could work, but you'd probably also be destroying your estrogen too
somebody help me out over my brainworms and confirm somethingis overall T or bioavailable T the important one?
>>35714124you should get a blood draw at peak and see how high your level gets
>>35707335mm, noalso give more detail
>>35708938wait.. is it bad if i'm injecting air into the vial? i'm confused
>>35715493you're intended to do that to keep balanced pressure so it's consistently easy to draw up your doseonce a vial has been punctured you should use it within a few monthsunpunctured will last quite a while but see my other post that estimates degradation of the med over time
>>35715574i guess i should be good when i use 27G and avoid hitting the same place
>>35707381sorry i was asleep. that seems like its a bit much, is that scrotally like the other person said?
>>35714124I had a natural resistance to my body's testosterone because of high SHBGs but I don't know if they affect estrogen as well
>>35705951fuck your dark theme nigga>>35714465i always measure total T but either one probably works it's not that deep >>35713675no, you're fine>>35714124different people different dosages. decreased levels are unrelated to estrogen sensitivity, which has more to do with the receptors and your genetics. your levels are fine now, right, so why worry?>>35712812no>>35712808probably the carrier oil. i haven't seen that particular color change to salmon but I've seen plently of them turn pale yellow>>35710885ummm uhh like placebo effect probably lol. either that or confirmation bias
teahrt coupons?
Something I just realized tonight that made it way easier to inject was realizing that self harm was psychologically easier for me than injecting, which is something that literally makes my life better. So I just stabbed, knowing that it would hurt and knowing that it was scary. This was one of the least traumatic injections yetHopefully somebody finds that useful
>>35714124don't inject in rectus femoris, too fast absorption
>>35718312i’m skinny as hell, there’s nowhere else to inject :(
>>35718321you can inject in ass
>>35718244I actually really like this mindset, if/when I switch to injections I think this will make it easier.
How do I sweat less? It smells different now but even on HRT I sweat a lot(I'm on a good dose, 11mg every 7 days EEn
>>35718473botox injections
>>35718547Huh?
>>35718553botox injected into your armpits will stop you sweating
>>35718556Maybe I'll just use deodorant instead
>>35718565it lasts for 7 months btw from what i can see it costs $270 in aus which is about 177 usd.
>>35715708scrotally, and this is levels used for mono, no aa. 4mg/day works for most people (if a bit excess), so if you can do bloodwork then start with that and adjust from there. better to overdose than hondose anyways
>>35716085>its not that deepmy total is too high, my bio availabe is extremely low ...>>35714465
>>35719015>my total is too high, my bio availabe is extremely low ...free testosterone is more important than total (can be calculated from total and SHBG)give the values
>>35718916If I choose to use an aa, what can I lower it to?
>>35718312is it okay if i subq while inject close to it
>>35719189subcutaneous is ok
>>357190730.76 mg/ml total T202 nmol/l shbghow does it matter more? explain like im 5yo pls
>>35719182there isn't much data on scrotal transderm+aa. standard transderm+aa is 4mg/day, so i suppose that'd be equiv to ~2mg/day scrotal
>>35719400>how does it matter more? explain like im 5yo plsandrogens bound by SHBG can't do anything>0.76 mg/ml total Tng/mL* = 76 ng/dL, that's quite a lot. how much estrogen?options:1. falsely high due to interference (immunoassays are vulnerable, LC-MS much less)2. congenital adrenal hyperplasia (enzymatic defects leading to impaired production of cortisol and in result not suppressed ACTH which stimulates adrenal glands to produce more precursors to cortisol which in higher concentrations lead to production of androgens; hydroxyprogesterone is measured for that)3. androgen-secreting tumor (in testicles, in adrenal glands)
>>35719465thx for explanation>a loti know, hence why i was worried about ite is high with 530pg/ml on troughEV 5mg/week>hydroxyprog measured for that17-Hydroxy-Progesteron is 2.67 ng/ml?
>>35719518>e is high with 530pg/ml on troughthen it's not because of your dose being too low>17-Hydroxy-Progesteron is 2.67 ng/ml?yeah, so it's probably congenital adrenal hyperplasia, it's above the reference range. although a tumor also can lead to elevation to hydroxyprogesterone.
>>35719586so im cooked?
>>35719657do tests (ultrasonography of testicles; computer tomography/magnetic resonance of adrenal glands; dexamethasone suppression test) and you'll know what you have.your SHBG reduces your T and DHT very strongly. if you're paranoid, you can add low dose bicalutamide (e.g. 50 mg once 4 days). it's also possible to decrease adrenal androgen production (if it's not a tumor) with synthetic cortisol, dexamethasone (bioidentical cortisol has inconveniently short half-life), just a little dose, but idk how much you can afford because of asymmetric peripheral-central action which causes insulin resistance and makes you gain more fat in belly instead of lower body.
I've been on HRT for a few years now (Currently on 100mg spiro and 6mg E daily, orally)Started taking progesterone (200mg rectally) last night. Can I expect any changes at all? If so, when?Breasts are noticeble and developed, but I'm hoping to help them fill up more with the progesterone.
>>35719727tysm for your help anon
sorry if this is a basic bitch questionhow are you supposed to keep a sublingual pill under your tongue?When I put it there, almost every time i start producing more saliva and i can feel the dissolved remnants of the pill slip out and go over my teeth
>>35720981i use a pill crusher to make a dust that way it just soaks up nearly instantly. other option is to just really really put it far back almost to where you dont feel it
>my levels are fine>i have natural d cups>i get random boners like five times a day and fantasize about raping every woman and man that walks past me with my six-inch, blood-engorged rod of death and destruction explain that, science people
bump
let's say i came into possession of a mostly full bottle of spiro 100mg tablets, but i can't afford to DIY estrogen as well, would just taking the spiro do anything worthwhile to me?
>>35718378so does it actually absorb faster in that muscle? why?
>>35723630you’ll pee a lot more, that’s it
planned parenthood wants to put me on 5mg weekly estradiol valerate shots, is that enough for monotherapy? the chart on transfemscience says yes but the chart at the top of this thread says no.
>>35724054that'll be fine. personally I'd do 4mg/5 days to get more stable levels but it should work
how fucked are you right now if you want to transition and live in the uk? is diy the only route?
>>35724971it's certainly the fastest route but don't forget to check your levels
>>35725863how? GP or online service?
how do usd to xmr now? localmonero is gone
>quit hrt beginning of year>took EV/EC but never AAs>~5 months later I don't have a masculine faceI wish I never took it, I still look relatively okay but I want more of the masculine features to return.
I think I have urinary incontinence. After I go to pee, I have a few more drops spill out into my underwear. This had only happened to me when I was a kid before.
>>35727652i am exactly the same. like this happened as a kid and only started again after i started hrt. try doing pelvic floor exercises. you basically tense the muscles and it feels like your innards are tensing. i think its sort of helped me but it still happens.
>save 4k for orchie>requires diagnosis and two letters of recommendation>diagnosis - $400>each letter - $400 (for clients)>service requires signing up>mfw I lose half of what I save if I want my nuts sliced off.
>>35727989>not letting your friend (or transbian lover) do your orchingmi
>>35728034cant, not a transbian, not even trans. I just have a fear of losing my mind and going rabid and on a serial testosterone fuelled raping spree and impregnating women.25m gay and a virgin
im post orchi and on injections. i got depressed and didn't do my injections frequently for a few months (like 9 ish months of doing it only like once a month, if that) is this something to be concerned about health wise? or should i be okayt if i just start being on schedule again?
>>35727989at this point you might as well just fly to thailand for one
Why am I still getting morning erections if my T is totally suppressed?
Hi /hrtgen/, my doctor prescribed me norethisterone as a progestin. Does anyone know anything about it? Should I just go to ihp and get endogest instead because I'm seeing the worst reactions to it googling.
my bloods are showing 750pmol/l of e and 52.0nmol/L of t, despite me being on 2mg of sublingual e a day. i think this is either a result of me being intersex, or the progis this why people cycle progesterone? any tips?
