>GlucosisEsoteric state of metabolism when your body has unrestrained capacity and preference to use carbohydrates as energy fuel due to 0 consumption of fats and extremely lean body composition (including absence of visceral fat) preventing leakage of fat to bloodstream, resulting in unlimited physical and mental energy, and extremely efficient cellular machinery. No human studies were conducted on it because it is too extreme and most people have some degree of obesity, making them unfit for it. >Look at what happens when DPP-4 null mice are fed high-carb, low-fat diets.
>>77355934You're a fucking retard with a remedial understanding of the energy symptoms in the body. Using a drug that does this would doom you to being a skelly dyel. It makes you burn through your glycogen fast as possible while slowing glycogen release from the liver. Regularly low blood sugar is going to put you in a persistent catabolic state. DPP-4 null + exercise = hypoglycemia, poor energy supply, fainting, confusion, or collapse.
>>77355966>Burn through your glucose fast as possible
>>77355966>DPP-4 null + exercise = hypoglycemia, poor energy supply, fainting, confusion, or collapse.Amusing ignorance. >DPP-4 inhibition contributes to the prevention of hypoglycaemia through a GIP–glucagon counterregulatory axis in micehttps://link.springer.com/article/10.1007/s00125-015-3518-7
>>77356011>Unironically using mice studies to justify bullshit claimsHey retard, it in effect does the the same thing as GLP-1s in addition to draining your only available energy source. Do you have any fucking clue how many studies never make it past phase 1 cause shit don't work the same in people?
>>77356016I used this study to disprove your mechanistic speculation, showing that in fact opposite of your assertion is true - and how little you understand biochemistry. >Do you have any fucking clue how many studies never make it past phase 1 cause shit don't work the same in people?DPP-4 inhibitors are used in humans and their effect on hypoglycemia are no different, it is stated in the study i provided:>In this study, we examined the mechanisms of the protective effect of DPP-4 inhibition on insulin-induced hypoglycaemia in mouse models. We found that the DPP-4 inhibitor vildagliptin markedly reduced the glucose requirement to maintain blood glucose at a targeted hypoglycaemic value (2.5 mmol/l) during a hyperinsulinaemic–hypoglycaemic clamp, suggesting a direct, protective effect of DPP-4 inhibition from insulin-induced hypoglycaemia. This finding is in agreement with the hypothesis that DPP-4 inhibition supports the endogenous hypoglycaemic defence as previous studies have shown for vildagliptin given to drug-naive patients [31] or added to insulin therapy in people with type 2 diabetes [32].
>>77355966>DPP-4 null + exercise = hypoglycemia, poor energy supply, fainting, confusion, or collapseI did this to myself once before by fasting for three days and then going for a 30k bike ride. Shit was getting weird by the time I got home, I was sure I was going to faint so I grabbed some juice from the fridge and chugged it down and then lay on the floor for a while.
>>77356076If you want to lose fat, how is this helpful? If you want to get strong, how is this helpful? If you want to build endurance, how is this helpful?
If you're a trooned out wog who never works out and only shitposts. I can see how this study is helpful
>>77356116>If you want to lose fat, how is this helpful? I described metabolic state one of requirements of which is extremely lean body. >If you want to get strong, how is this helpful? >If you want to build endurance, how is this helpful?Extremely efficient glycolysis directly boosts strength and endurance, as well as heightened insulin levels coupled with extreme insulin sensitivity being anabolic and enhancing production of androgens. You would probably still need to combine multiple carbohydrates like glucose and fructose due to absorption limits for maximal benefits.
>>77356126I'm glad it's helpful for you.
