Top 2 causes of death are cardiovascular diseases and cancer. Statins can completely prevent atherosclerosis, and by extension myocardial infarction and stroke - but there's no reliable way or a drug to prevent cancer. Sad!
>>77392482I'm currently on telmisartan 40mg and feeling really good and calm at that dose. Might even go to 80mg and maybe even add nebivolol 2.5-5mg. My LDL cholesterol is already under control at 48 with pitavastatin and reta.
>>77392493>Might even go to 80mgNot a good idea, telmisartan increases rate of liver aging.
>>77392496Source?
>>77392499They found it because diabetics experienced high incidence of liver-related side effects. All -sartan drugs inhibit GLO1, but telmisartan does it the most. >Association of glyoxalase I inhibition by angiotensin II receptor blockers with adverse events in diabetic patientshttps://www.sciencedirect.com/science/article/pii/S3050567426000027
>>77392482>there's no reliable way or a drug to prevent cancerExtended fasting
>>77392505In-vitro study and retrospective database number fudging. If there's no clinical trial showing significant ALT/AST increases with telmisartan over placebo, it's most likely just something theoretical that maybe occurs are gigadoses.
>>77392510>significant ALT/AST increases with telmisartan over placeboAging is a slow process that does not lead to immediate ALT/AST increases. Liver aging is not the same as immediate liver damage that occurs during short trial duration. Diabetics have increased rate of this side effects because they have higher methylglyoxal load which GLO1 detoxifies, basically acting as accelerated aging model.
>>77392508A meme. Probably increases risk of cancer long-term due to organ degradation and decreased metabolism.
>>77392530>Aging is a slow process that does not lead to immediate ALT/AST increases.Every drug that somehow affects the liver shows an immediate effect in at least a few participants of clinical trials. The notion that a drug somehow causes damage but only years or decades later and is never picked up is completely ludicrous.>Liver aging is not the same as immediate liver damage that occurs during short trial duration.Liver aging is liver damage. Liver damage can occur quickly once a new drug is introduced to the system.>Diabetics have increased rate of this side effects because they have higher methylglyoxal load which GLO1 detoxifies, basically acting as accelerated aging model.Again, you are basing this all on in-vitro studies and retrospective database number fudging. Mechanisms without outcomes are worthless. Just think of the thousends of medications that potentially can grow hair but do jack shit in humans.
>>77392544>Mechanisms without outcomes are worthless. So basically you don't value pharmacovigilance data since you don't consider it as a type of outcome.
>>77392553I consider retrospective data based on a single Japanese database query as meaningless, yes.
>>77392557Weird science denialism but ok...
>>77392560There is this thing called pyramide of evidence. You should look it up before making claims about science.
>>77392482Statins are ancient trash therapy. Black cumin sneed oil is better ACK prevention among basic bitch shit. Stop posting Mr. Looksmaxxing skill issues there, my ass tryin to bulk.And uh FYI... look up the experimental BromAC cocktail, probably prevents most kinds of cancers fairly effectively and I yolo cycles of it all the time among others.
>>77392563Hey there fisetin schizo. Still mad about even the mechanisms behind fisetin being completely debunked? Guess you'll never grow your hair back at this rate..
>>77392561>There is this thing called pyramide of evidence.And it represents pharmacovigilance data as meaningless and scientists doing this type of research as fools... Nope, doesn't happen.
>>77392564You can keep trusting the (((NIH ITP))) instead of all the other research saying it works, but it's really as simple as knocking down your COMT and using a solvent, breh.Here are some other new "mechanisms" for making it do shit...>Role of Lecithin in Modulating Fisetin Release, Mitochondrial Membrane Depolarization Anticancer Activity, and Mitochondrial Dysfunction in Biopolymer NPs>https://link.springer.com/article/10.1007/s12668-026-02723-1
>>77392566RCTs supersede in-vitro studies and retrospective database number fudging. RCTs prove that telmisartan at high doses is safe for liver function and may even help attenuate NAFLD.https://pmc.ncbi.nlm.nih.gov/articles/PMC3755443/
>>77392571Even the Mayonese Clinic has debunked fisetin. It's fucking over for fisetincels.
>>77392574>muh apple-eel 2 aww-4-ityWhatever, breh.>Fisetin Attenuates CCl4-Induced Liver Injury in Mice: Emphasis on the Modulation of TGF-β1/Smad3 and p53/Bax/Bcl-2 Pathways>https://www.sciencedirect.com/science/article/pii/S0014299926006072>Fisetin prevents deterioration of cellular functions in amyotrophic lateral sclerosis variants G262R and P438L of SQSTM1 in SH-SY5Y cells>https://www.sciencedirect.com/science/article/pii/S0041008X26002395>Pharmacological mechanisms of fisetin in neurodegenerative disorders: regulation of neuroinflammatory, oxidative, and autophagic pathways>https://link.springer.com/article/10.1007/s00210-026-05656-4>Intra-articular therapeutic effect of fisetin on temporomandibular joint osteoarthritis and its application for sustained release>https://osaka-dent.repo.nii.ac.jp/records/2000572...all that just dropped in the last WEEK, breh.
>>77392578>"hello chatgpt saar please write me a fake study showing that fisetin has some positive effect in mice with special mutations saar"A few decades ago GSK fell for the resveratrol scam and lost hundreds of millions. And now it's your turn to be scammed for all your money with fisetin.
>>77392563>look up the experimental BromAC Cool, i have some bromelain from China at home. Will mix it with NAC now. Recommended dosage?>probably prevents most kinds of cancers fairly effectivelyCould you please explain some of the mechanisms? >cycles of it Why cycle and not use it everyday? Wouldn't wanna be vulnerable for cancer during off-time.
Statins give you dementia and make you go blind.If you take that poison you will destroy your life.
>>77392589Statins have a neutral effect on dementia rates and don't affect the eyes more than placebo. They will save your life.I understand you are either a carnitard or one of those subhumans who want to make other people's lives worse by giving harmful advice. Kill yourself.
>>77392589>make you go blind.Kek, where you got this idea from?
>>77392599Carnitards lie about everything. Their king (((Norwitz))) even tried to hide the primary outcome of the ketard study he performed, got his paper pulled for it and is now still lying on youtube about it. Grifters are such scum.
>>77392493>statins>telmisartan...
>>77392609The best
>>77392601Can you redpill me on "lean mass hyper responder" meme? Keep hearing it in discussion about atherosclerosis but have no idea what it's about and whether it's real or not.
>>77392611There are certain people who, if they go on keto, go from "normal" LDL cholesterol levels to insanely high LDL cholesterol levels. Norwitz and another guy ran a study on very healthy 50-something year olds with otherwise perfect blood parameters who happen to be such LMHR. Their hypothesis was that they wouldn't develop more plaque than the average population even on such high doses. When the paper came out, the primary outcome (plaque progression) was omitted from the paper in favor of a subgroup analysis showing that there was no statistically significant difference between the high LDL-C subgroup and very high LDL-C subgroup in terms of plaque progression. Of course people quickly noticed that the primary outcome was changed, ran the calculations based on the provided data in the study and figured out that the average plaque progression over all participants was diabetics-tier bad. This of course resulted in Norwitz's paper being retracted.
>>77392572Sounds like you have it all figured out, looks like you need to pump the dose to 120!!
>>77392482That guy looks like an annoying highschool bully chad. I'm glad he got cancer.
>>77392580>A few decades ago GSK fell for the resveratrol scam and lost hundreds of millions. And now it's your turn to be scammed for all your money with fisetin.Resveratrol isn't a scam either; yes, it had some research fraud but many negative results were also mostly solubility and metabolism skill issues aside from that. Also, I do GSK-3 beta inhibitors among other shit to not end up like OP moid, kek.>>77392582>Recommended dosage?I'm typically doing 500mg bromelain and 1.2g NAC, but doses up to many grams are currently being studied in active cancers and have been used in other clinical trials for other conditions.>Why cycle and not use it everyday? Wouldn't wanna be vulnerable for cancer during off-time.I usually run fairly long cycles of a month or two straight each quarter. Cancers typically don't grow that ultra-fast, I usually cycle off it and onto other RC chemo cocktails instead anyway, and I don't like running the same thing too long because that's how chemoresistance occurs due to random mutations if you actually happen to have cancer. Look at cancer patients who get monotherapies; typically things start out pretty well if selected properly, but eventually mutations occur causing resistance, then cell division explodes and ACK. Glioblastoma is maybe the most classic case of this because a lot of them usually just get TMZ, things start out great with some remission and they're almost all dead like a year later.>>77392594Statins are better than nothing if you're a thirdie cardiac patient from the 1970s, but generally they're kinda outdated by now.
>>77392582>Could you please explain some of the mechanisms?Here is an overview of what it does to ass cancers; there are in vitro studies on most other cell lines out there with some overlap in mechanisms but also some different ones.
>there's no way of preventing cancerHave you ever heard of not stressing, avoiding sugar (that actually feeds cancer cells), intermittent fasting and getting enough sunlight (an anglo living in Australia is a poor example)?
This is cool. I didn't learn a single thing from this dicussion. One person asserted something, someone else came along and asserted the opposite, then a third person said something else. That is how every discussion on here goes. It is a complete waste of time to read them, since you will never learn anything if you are not already an expert.
Minoxidil lowers blood pressure and gives you hair. It should be first line treatment for men.
>>77393002What's the alternative to Pitavastatin then?
>>77393022True I was just trying not to have a stroke.
>>77392482ai tailored personal vaccines can kill cancer reliablyAi is pretty powerful
>>77392482Ivermectin and fenbendazole
>>77393036He's right, there's many alternatives. Just google drugs that lower LDL. Scientists are already researching genetic engineering technology to delete protein responsible for LDL receptors breakdown.
>>77392482The japan accidentally discovered a vaccine to some specific cancer like 40 years ago and it got buried, cultures destroyed, ect. We'd have probably cured it by now if it wasn't for that. In general vaccines are really promising a lot of cancers since detecting the cancer cells before it grows is probably the earliest stage prevention and is something they already do until you roll one they don't recognize.
Wasn't it only a couple of years ago that some study actually cured colo-rectal cancer every single specimen they tested on? dostomab or something like that? Are immunotherapies gonna be the silver bullet against cancers?
>>77393423>colo-rectal cancer A S P I R I NSPRIN
>>77392540your whole existence is a meme, you brown muttnigger
>>77392482Statins inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress.
>>77393461Fast if you want to look like a concentration camp dweller.
>>77392482Statins dont do shot other than lower choelsterol in your blood test. and the link between blood choelsterol and aterosclerosis is weakly correlative, not at all causal.The only group of people for whom stats are DEMOSNTRATED/PROVEN to reduce heart attack and strokes is among people who have already had one, and the reduction is very slight. Statins are gay.
>>77393999>and the link between blood choelsterol and aterosclerosis is weakly correlativeHumans with low cholesterol never develop atherosclerosis, while those with normal or high always do.
>>77392986the obvious answer for everyone should be to take the minimum effective dose120+ may be good for roiders though... they have to take some calculated damage from ancillaries in order to prevent massive damage down the line>>77393489much better to lower LDL through supplementation of multiple antioxidant pathways and eating enough fiber and leafy greens to keep bile cleanif it still doesn't work (because of genetics) then statins are acceptable>>77393999>the link between blood choelsterol and aterosclerosis is weakly correlative, not at all causalnah, that's wrong. if you get LDL low enough with statins then atherosclerosis simply doesn't form or progress. the controversy is in whether they extend life or not and that depends on way too many factors beyond that singular measure.
>>77394148>whether they extend life or not Obviously they do. Atherosclerosis is #1 cause of death and is implicated in many degenerative diseases.
>>77392493>ArtanWithout looking I'd bet money that's angiotensin blocker
>>77392510Well every doctor will send you for regular liver enzyme tests even on like 20mg of "artans"
You guys might find this funny. Heart disease runs on both sides of the family. Dad was in Vietnam, hosed with Agent Orange, and is now slowly dying of lymphoma and prostate cancer.My cholesterol has been under the radar for years. Got a calcium scrape and have some gnarly scores for the top right and lower right arteries for plaque.Went on a regimen of fasting every day, taking loads of Nattokinase, NAC, K-2, L-Lysine, Vitamin C, and more daily along with taking a statin. Plaque still progressing. This is a side effect from Agent Orange and I'll most likely die young due to aggressive heart disease.
>>77394709> Plaque still progressing.How you measured it? And how your cholesterol scores changed after starting to use statin and supplements? Do you have high LP(a)?
>>77394745Calcium Scrape measures the amount of plaque. Doesn't measure blockages, have to do quite a test for that shit.Cholesterol went down a smidge with statins, not impacted at all with the supplements. Even stopped all alcohol, because le inflammation.Actually, scheduled for an apoB and lpa blood draws to see what's what next month.
>>77393001>self insert headcanon>wishing a stranger harm in any way is righteousGo away nigger
>>77394805>Calcium Scrape measures the amount of plaque.Increase in calcium score does not mean more plaque is being generated, you are probably fine, depending on apoB score. >Cholesterol went down a smidge with statinsTry adding ezetimibe, makes a huge difference for some people, like picrel.
>>77392482statins only decrease your risk of ischemic stroke. They actually raise it for hemorrhagic stroke. Taking statins is a midwit signifier
>>77394856>statins only decrease your risk of ischemic stroke.If you lower apoB enough (with statins or other drugs), atherosclerosis cannot develop. Without atherosclerosis there's no possibility for stroke or infarction. https://www.youtube.com/watch?v=R1L0lLmw-b0
>>77394847I'll check it out, thank you anon
>>77394883>Without atherosclerosis there's no possibility for stroke or infarction.Hemorrhagic strokes can come from all kinds of other blood vessel diseases such as Cerebral Amyloid Angiopathy, ischemic strokes can also occur from blood clots secondary to many conditions instead of plaque, so no.
>>77394886If your test will show high LP(a) levels, you might benefit from aspirin use. >Aspirin use, lipoprotein(a), and calcific aortic valve disease: the Multi-ethnic Study of Atherosclerosishttps://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehag018/8493293
>>77394888>Hemorrhagic strokes can come from all kinds of other blood vessel diseases such as Cerebral Amyloid Angiopathy, ischemic strokes can also occur from blood clots secondary to many conditions instead of plaqueQuick google search indicates this conditions overlap with atherosclerosis. To conclude they are possible without atherosclerosis would require direct observation of it in people with miniscule amount of atherosclerotic plaque.
>>77393008With a compound having such a wide effect on multiple types of cancer, i wonder if it may have cytotoxic effect on healthy cells. Probably worth it anyway.
>>77392482It's called aspirin, retard.
>>77392482I eat 130g+ of sat fat a day and my TC was 131 on my last test, last full test had me with an LDL of 37 (been trying to get it over 150 for YEARS) and a trig:HDL ratio (the real danger metric) of .7, meaning I'm in the top quintile of cardiovascular health.Why won't you nerds just admit keto is the way?
>>77394932Cholesterol is mostly genetic.
>>77392482Facial skin grafts always look worse than leaving the injury alone.
>>77392482>but there's no reliable way or a drug to prevent cancerParasites cause cancer, fasting and ivermetum kill parasites
Statins gives you Alzheimers and dementia. Cholesterol is good for you, your brain is mostly Cholesterol so thats why you get dementia when you take statins
>>77392482New study on aspirin and cancer. >The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Reviewhttps://www.mdpi.com/1422-0067/27/3/1288
>this whole thread>Ezetimibe only mentioned ONCE>no Repatha at all for anon with familial cholesterol issues>Forgetting that BP is arguably a bigger and more brutal contributor (high BP also cause kidney explosions), and that incidentally, BP meds can also help with general heart healthThis board is ass
>>77396015>Statins gives you Alzheimers and dementia. This never happened. They marginally reduce working memory and marginally increase transition of pre-demented humans to demented.
>>77396021>it never happened! Ok it happened a lil bit!lol go get your covid booster
>>77396164Statins are never directly causative to the development of cognitive diseases. Anyway, enjoy your atherosclerosis.
>>77396182Yeah bro and covid vaxx doesn't cause myocarditis too right
>>77396238No one mentioned covid, nigger. I never even researched it because i do not consider it a risk factor for disease development for someone of my demographic, unlike atherosclerosis.
>>77394892I'm hoping the therapeutic levels of Nattokinase I'm taking will be a more natural blood thinner than aspirin in that regards.
