Today I will be dropping a guide for you guys who are depressed/anxious/fearful and those who seek to break bad habits, grow, increase neuroplastogenicity. Those who want to discover themselves truly. Protocol:10 mg DMT300 mg moclobemide.Take the moclobemide 30-60 minutes before dosing the freebase DMT orally. 5-10 mg aticaprant1 gram agmatine sulfate10 mg ACD8565 g piracetam1 mg lithium ascorbateThe DMT can be dosed anywhere from 5-30 mg but be careful at the higher doses as there is a risk of anxiety/panic and potentially psychosis for those vulnerable. All of these compounds can be found with a little research. Studies:Cameron et al., 2019 — ACS Chem Neurosci (doi 10.1021/acschemneuro.8b00692)"Chronic intermittent low doses produced an antidepressant-like phenotype and enhanced fear extinction learning without affecting working memory or social interaction."Szabo et al., 2016 — Front Neurosci (doi 10.3389/fnins.2016.00423)"DMT protected human iPSC-derived cortical neurons and microglia-like cells against hypoxia via Sig-1R, which acts as an ER–mitochondria interface chaperone regulating the ER stress response."Erritzoe et al., 2026 — Nature Medicine (doi 10.1038/s41591-025-04154-z, PMID 41699126)"Phase IIa double-blind placebo-controlled RCT of IV DMT (SPL026, DMT fumarate) in moderate-to-severe MDD: a single 21.5 mg dose infused over 10 minutes with psychotherapeutic support, primary outcome MADRS change at 2 weeks, followed by an open-label second-dose phase. (PubMed) Mean MADRS difference was −7.35 vs placebo; response was 35% vs 12% and remission 29% vs 12% at week 2, across 34 randomized patients."Morales-García et al., 2020 — Transl Psychiatry 10:331 (PMID 32989216)"DMT activated the subgranular zone of the dentate gyrus, generating new neurons in the granular zone, with mice performing better on memory tests. The neurogenic effect appeared to involve sigma-1 signaling, since an S1R antagonist blocked it."
Neuroplastogenic, default mode network disrupting, fear extinction, antidepressant, and neuroptrotective to summarize. All the other compounds i listed are synergistic with DMT. If you are curious to learn more look into 5HT2A receptor and sigma 1 receptor as starting points.
Other interesting topics include aticaprant KOR antagonism. Increases fear extinction, stress resilience, improves socializing. Amplifies DMN disruption with DMT. ACD856 TrkB PAM -> neurogenesis, will amplify DMT neurogenic effect.
>>77470224and just where am I supposed to get all that shit from, faggot?
Why Lithium Ascorbate instead of Orotate?
Or I could just do mushrooms every five years and be perfectly fine.And neuroplasticity does exactly fuck all if you don’t acquire new skills and actively build new pathways.I recently placed a deck of cards on my desk and do different shuffles and tricks instead of fidgeting with something random. Hand dexterity gains are out of this world.
>>77470224fuck off hippie
>>77470466Not true. Increased BDNF is antidepressant. Of course, combining with good habits is optimal and encouraged. Great opportunity to learn a new skill, read more books, etc as it is more likely to stick around. But the mood benefits stack over time.
>>774704522022 paper by Torshin, Gromova show lithium ascorbate as a neuroprotector, evaluated against the known toxicity of other lithium salts (nih) . Related rodent work reports stronger stress-protective and antidepressant-like effects than lithium orotate in open-field and forced-swim testing (Normotim) , plus a much wider toxicity margin.
>>77470224Seems like a lot of work just to get the same effect as the khat kava combo
>>77470471I'm a hippie for improving cognition, mood, and stress resilience? Weirdo
>>77471456The mechanisms are entirely different and the resultant effects are not comparable. Neither Khat nor Kava are enhancing or nootropic in any way. Especially long term.
What do you think of the Stoned Ape Theory OP?
Me I would not try to take it all at once. I would have a psychedelic nuke one day, then begin taking my stack afterward. The idea being to open a neuroplasticity window and then radically change your habits and lifestyle with other drugs while that window is open. I would personally just use something like mushrooms followed alcohol or kava with a mild stimulant and maybe a beta blocker. If you want a stack you can take daily why not just use 4’-DMA-7,8-DHF and Erinacine A as your neuroplasticity modulators. That shit would work very well in theory and seems less risky to me. Also easier to obtain
>>77470407Um, you know the local nigger dealer wearing a hoodie with his ass hanging out. He's got all these magic instruments for you to become ubermensch.
>>77470224Anyone that tells you that you can "discover yourself fully" that's a sure sign to run because discovering yourself fully is not a thing. We are not an identity we are a gap of identity. If you don't believe me I encourage you to try to find yourself. I think you will find it to be a vague ass experience where at the end you make up some stupid story to justify what random shit happens to you.
>>77471452Lithium Orotate in similar dosages possesses zero toxicity and rodent studies are worthless. I've yet to see any valid literature showing a clear benefit over Orotate. You're paying more for nothing. Lithium Orotate is well absorbed and safe.
>>77470231DMN disrupting effects are to be attenuated, otherwise you could induce a permanent state of psychosis.
>>77471706I actually agree with you on taking a stack during the neuroplasticity windows, but not the things you chose with the exception of beta blockers as those would also contribute to fear extinction. I prefer ACD because it is a PAM and promotes things that naturally increase BDNF by amplifying them such as exercise. Propranolol is ass however and anti dopaminergic among other shitty effects.
>>77471637Hogwash probably. Although people love to get high, so it probably had at least some effect on our trajectory. But I dont know enough to say anything conclusive.
>>77470224>"I'll just take this psychedelic stack brooooo it'll solve all my problems"Nah mate. Work on yourself DAILY. Take this from someone who was dedicated to psychedelics in his early 20s. They are potent medicines for the mind but you need to have put the work in beforehand. It's like taking steroids, if you've never worked out in your life and you blast test you'll get some results . Vs. If you've hit your 'natty potential' and THEN add roids on top of it and it'll take you so much further.You want your mentals as good as they can be before you hit those powerful psychedelics, if you're a piece of shit and think that a megatrip is going to change that you're a fucking idiot and will end up mentally graped. Just look at how much more retarded society is since psychedelics have taken off in the past few years thanks to Blow Rogan and those other fuckheads.(Also if pharma companies are experimenting with them and planning to use them as 'therapy' then you should be wary and know that they are another tool of control, not to be too noided or anything)
>>77470407You can do acid base extraction on acacias for DMT
Mushrooms don't work on me, I wonder if dmt will. I'm definitely not buying it from some dirty guy handling it in his bedroom though
>>77472317Big pharma is making non-psychedelic analogs of triptamines and lysergamides for treating various things. Ketamine is the mind control drug they're pushing. That's how the wachowski bros got hypnotized into trooning out.
I'm very confident that oral dmt doesn't do anything, nice one OP
