Ok so allow me to explain:

Transgenderism is the concept that a person’s subjective gender identity can differ from their biological sex (chromosomes, anatomy, gametes - binary in humans, male/female). It involves gender dysphoria (distress over the mismatch), social changes (names, pronouns, presentation), and often medical steps (hormones, surgeries). Advocates see it as innate; critics cite social influences, comorbidities (e.g., autism, trauma), high natural desistance in kids, and rising detransition concerns.

Losing means defeat or deprivation: failing in competition (game/sport), suffering loss (loved one, money, status), or decline (losing control/hope). Opposite of winning/gaining; can be literal or metaphorical.