For the discussion of cryopreservation of biological organisms and cells.https://www.nature.com/articles/s41467-023-38824-8Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model>We show that vitrified kidneys can be cryogenically stored (up to 100 days) and successfully recovered by nanowarming to allow transplantation and restore life-sustaining full renal function in nephrectomized recipients in a male rat model. Scaling this technology may one day enable organ banking for improved transplantation.This is a major breakthrough in cryopreservation, for the first time and entire organ has been successfully cryopreserved, and remains viable once thawed. Previously, the state of the art was just a small biopsy sample of ovarian tissue.As a future research area, this can be combined with running AI on brain organelles. The computational function of each brain organelle can be measured digitally before and after cryopreserving and thawing, thus allowing rapid, iterative, perpetual and objective improvement of the cryopreservation process until it reaches a sufficient level for brain transplantation and clinical immortality.https://www.biorxiv.org/content/10.1101/2023.02.28.530502v1>Here, we develop Brainoware, living AI hardware that harnesses the computation power of 3D biological neural networks in a brain organoid. Brain-like 3D in vitro cultures compute by receiving and sending information via a multielectrode array. Applying spatiotemporal electrical stimulation, this approach not only exhibits nonlinear dynamics and fading memory properties but also learns from training data.The object is achieve clinical immortality through brain cryopreservation, and then implantation of brain-computer interface on nanowarming for brain-in-vat type first-generation immortality. Organ cloning, DNA repair to follow in second-generation research.So what do you think, /sci/?
>>17017295>The object is achieve clinical immortality through brain cryopreservationNah, but got another idea here. Reliable freeze-thaw cycles coupled with rejuvenat treatments during the brief thaws. Next habitable world five hundred years out? Hold mein Bier ... :)
>>17017319Immortality is indeed the easiest way to achieve intergalactic space travel. Time and life support no longer become an issue, just the bare minimum delta-V. Rejuvenation is only needed for radiation damage to DNA from intracellular potassium isotopes, which is limiting factor on conventional cryopreservation.
>>17017347Indeed. And you might not even need to aim for "immortality" exactly even, just reliable cold sleep and fixing accumulated damage periodically.
>>17017526It might even prove possible to prevent radiation damage in the first place, with some form of isotope exchange and radiation shielding. This is probably how the Greenland Shark can live 400 years, deep underwater shielding it from cosmic radiation, and far away from uranium containing rocks releasing radon gas.
