what are the best tips to avoid hitting the wall as a man?
>>76568063Don't lose your hair, grow out facial hair to cover saggy skin and jowls, keep fit and a low blood pressure.
>>76568076>Don't lose your hairIs finasteride enough for this? I'm 29 and just started a year ago>grow out facial hair, keep fitdone>low blood pressureMy doc says this looks perfect on every checkup so should be good here too
>>76568063>eat clean>stay away from trashy people and that includes hookup culture>drink water brudduh>be natty stay nattysimple as
>>76568063>what are the best tips to avoid hitting the wall as a man?Don't marry Amber Heard
>>76568096>stay away from trashy people and that includes hookup cultureIs it just because of stds? I don't drink so not getting drunk at 3am but I do like inviting tinder thots to my place for a healthy dinner and cardio session at my bed
>>76568089>Is finasteride enough for this? I'm 29 and just started a year agoNoAdequate sleep, nutrition, social bonding, and stress management will do this.
>>76568089finasteride will turn you into a tranny.it softens the skin and makes you look less masculine, just look at everyone who uses it.not worth saving your hair if women also don't find you attractive because you look like a freak.
>>76568106Why would you do cardio in your bed? Isn't that what treadmills and walking trails are for?
>>76568113Aren't most A-list celebs on it? They look pretty good to me. Idk anyone bald that has a decent looking girl at all besides those that locked in a marriage and kids or pay girls to be their gf for events>>76568114just with girls at the bed. Alone yea treadmill and walking trails
Jlo is on like one in a million in terms of genetics, maybe more. And on has a lifetime of partying and drug abuse behind him and the other worked out her whole life.
men who are lazy don't perform physical activity suffer andropause otherwise no such thing for active healthy males
>>76568106>jeetposting
>>7656806399% of men don't want to hear this, but sunscreen
>>76568076Yup doing this right now, also get a buzzcut
>>76568063It's mostly genetics.But retinoids, botox, facelifts all work.
>>76568063Be lean forever, lift, drink urine, play call of duty
>>76568076>>76568089>grow out facial hair to cover saggy skin and jowls>stay fitfit people dont have saggy skin or jowls you retarded zoomers. Take your Onions asses back to plebbit.
>>76568063good sleep EVERY night. Statistically gives the highest return in aging well followed by religiously watching what you eat only eat nutritious food no icecream pizza or other crap. Finally its excercise daily.
>>76568063Wear lots of make up like the old hoe on the right.
>>76568971You lose collagen and eslastin in your face as you age, this you sag, wrinkle and jowl up
>>76568063Dont smoke
>>76568168Don't forget that every photo of her is airbrushed, she has professional makeup artists, stylists, and dieticians.
>>76568063This is a bait thread right? People don't actually believe men age worse than women right?
>>76568076Hair style is huge too. At a certain length it makes me look five or more years older.
>>76568076>grow out facial hair to cover saggy skin and jowlsIt's kind of crazy how so many older men don't realize the can do this.
>>76568089I'm in my mid-30s at Norwood 1.5. I started balding around 30 but finasteride froze my hairline in place. It works. Don't worry about the sides, it's made-up bullshit by salty hairlets.>>76568113Jesus Christ the nonsense you bald fags come up with.
>>76570215The truth is that both sexes age like shit because most people don't take care of themselves. I know women in their 50s who work out and live a healthy lifestyle and they're still very fuckable.
>>76568063I peaked at 38 but ok
>>76568063muted this dumb cunt a long time ago
>>76568063things to do>sleep/recovery/relaxation>nutrition>movementthis are the main thingsif you can manage your hormone levels and stress you will age good(on top of this you can add all the lookmaxxer shit like skincare, biohacking, supps etc. to aid)things to avoid>stress>drugs>irregular sleep
>just dont have a stressful life bro
>>76568063Don’t drink, do drugs or smokeAlso wear sunscreenThat’s literally all you need to do
>>76570215Im gay now. Thanks
Get rich and then your wall has no ending
>>76571171
>>76571375Hey man, you asked
>>76568063Obvious ragebait but kinda funny
Get plastic surgery every year like Jlo I guess. Or be a giga chad like brad pitt
>>76568063I've nothing to say about your topic but your picrel is really good bait. Perhaps the best troll I've ever seen from a woman actually
Don't have sex with Amber Heard, I know you can do it anon
>>76571707>tfw no amber heard gf to shit on your bed
>if you lose your hair, buzz/shave it and don't cope.>lift>don't devolve into only wearing t shirts + athletic shorts, especially if you don't have a top 1% build>don't do drugs/drink>don't ruin your skin in the sunits that easy
>>76568063ask yourself: who do you think drank more alcohol and did more drugs in that picture
>>76571826Jlo skin was preserved by all the baby oil it absorbed for years with diddy
>>76570811Maybe they have gray or splotchy facial hair and it doesn't look as great.
>>76570215No, its inherently cope by women who are basically just going>I KNOW WHAT YOU ARE BUT WHAT AM I?like children because they can't argue
>>76568063Sunscreen, finasteride, dont get fat
>>76568063Don't marry someone who shits the bed.
>>76568994I literally just ate ice cream
>>76568063>what are the best tips to avoid hitting the wall as a man?die before 40+ become forever young
>>76571375Depp's trajectory scares me as I look good at 39 and with a similar phenotype, he suddenly went to shit and I don't want that to happen to me in just a couple of years.
ITT: decent normie-tier advice except the ancient hair drugs.The real S-tier next-level shit is senoprotein modulation, like DWS's Yamanaka factor cocktail only expanding into far more targets associated with aging instead of just stemness. If you stay on top of publications in Nature and do some reverse network pharmacology on new targets, you'll mog even 99% of influencers, cuz they don't know that shit.>t. "pharma anon"
>>76572966provide more information, also what "ancient hair drug" ?
Plastic surgery
>>76568063don't do drugsdon't be a clowndon't date women who will shit your bed
>>76573446HMGB1 recently came up on /sci/, see >>>/sci/16771556GAS6 and IL-11 are also fairly well-established targets now that you can find lots of literature on.
>>76568063J Lo is younger than Johnny Depp.
>>76572966Post face
>>76573446>what "ancient hair drug"fin and min
>>76568063excellent fitness question anon
>>76572966>Yamanaka factorgood luck with your cancer
>>76568063do the bare minimumlive a happy and low stress life (within reason)exercise and balance sun exposuremoisturise, eat healthy, sleep wellthats all it takes
>>765740042022 called, they want their paranoia back: https://pmc.ncbi.nlm.nih.gov/articles/PMC10373966/>tl;dr small molecules can reset transcriptome expression without actually inducing stemness
>>76568063Well Johnny Depp began smoking at age 12 and seeing as he's still doing it now I'd say don't smoke for 50 years straight and you'll probably look better than he does.
>>76574082>in vitrodo you even read methods sections, this below even animal study evidence
>>76574112Surely when you use the same molecules on an entire organism, they must actually behave differently and induce stemness.>/s
ZERO alcohol ZERO alcoholZERO alcohol Lift weights 3-4 times a week, Roon or some other cardio 2-3 times a week. Drink lots of water and eat clean. That easy. 41 here.
>>76574123Oh, and you may not like to hear this, but marriage - if you find the right woman. If you find the wrong one (which is >90% of them) you’ll definitely age more.
>>76568063>what are the best tips to avoid hitting the wall as a man?Just do what women do and wear loads of makeup
>>76574122>Let's see what the PubMed paper he linked says>Although the potential of these and other combinations of chemicals to achieve cEPOCH is great, from treating blindness to liver failure and skin damage, in light of the toxic effects of expressing all four Yamanaka factors in mice [22], it is critical that the safety of chemical rejuvenation cocktails is tested rigorously in mammalian animal models before human trials are initiated>the retard doesn't even read the clearly cited work in the papers he fishes from PubMed, let's look at [22]https://doi.org/10.1016/j.cell.2016.11.052>cyclic induction of OSKM for 8 weeks in mice carrying two copies of the OSKM and rtTA cassettes led to increased cell proliferation (Figure S3E) and teratoma formation in the liver, kidney, and pancreas
>>76574149>Current Opinion in Genetics & Development Volume 93, August 2025, 102351>Unlocking regeneration: how partial reprogramming resembles tissue healing>https://www.sciencedirect.com/science/article/pii/S0959437X25000437>Partial reprogramming rejuvenates cells>The landmark discovery by Izpisua’s team opened a new dimension of potential applications of OSKM in regenerative therapy. The findings suggested a way to leverage the potential beneficial effects of cellular and epigenetic rejuvenation by OSKM in vivo, while avoiding the detrimental effects that many others had encountered during in vivo reprogramming, such as teratomas or tumor formation.
>>76574123Yeah I've never really drank, been drunk like 3 times in my 20s and now 33, never drank any alcohol regularly. Had like 3 beers total in my life. I'm aging much, much better than everyone else my age. Joints fine, sleep fine, feel fine. My knees are slightly worse than when I was 25, but I think that's from jumping off the climbing wall which I don't do anymore. I don't stay out in the sun long either.
>>76574165>he thinks genetically modified mice with an inserted gene to promote OSKM expression is reflective of what will happen to humans>the mechanism to induce OSKM expression doesn't even exist in real mice or humans>even some of the transgenic mice explode into tumoursgood luck with your anti aging therapeutics in vivo on humans
>>76568063Moderate drinking, stay away from drugs and never stop lifting
>>76574210Uh, the research is *way* past just transgenic mice and viral vectors at this point...>In Vivo Reprogramming of C. elegans using genetic and chemical approaches>https://iris.unil.ch/entities/publication/4ae5239f-23b6-4554-a43b-b6b17ed1e256>Using Small Molecules to Reprogram RPE Cells in Regenerative Medicine for Degenerative Eye Disease>https://www.mdpi.com/2073-4409/13/23/1931
>>76574261> Nevertheless, the effects of in vivo reprogramming in different organisms have been relatively understudied. >During my thesis, I investigated for the first time in vivo reprogramming in C. elegans. >Importantly, instead of rejuvenation effects, I observed premature death occurring at different developmental stages. >In this line, the expression of reprogramming factors led to premature death in C. elegans, with varying levels of toxicity depending on the developmental stage and aging process.lmao you really just read the titles hahaha, gj you trolled me
>>76574280>Furthermore, we identified an optimized combination of two reprogramming molecules capable of alleviating additional aging phenotypes, including cellular senescence and oxidative stress. Importantly, applying this two-chemical combination in vivo significantly extended the lifespan of C. elegans.
>>76574287let's see their preprint>https://www.biorxiv.org/content/10.1101/2024.05.03.592330v1.abstract>The four C. elegans orthologs, ceh-6, sox-2, klf-1, and lin-28, were cloned into individual plasmids and microinjected as a pool of plasmids. After recombination, heritable extrachromosomal arrays containing multiple copies of the reprogramming factors were generated, and reprogrammable worm strains (4F) were selected (Figure 1A and Figure S1A). As the transgenes were under the control of a heat shock promoter (Figure S1A), we first optimized the conditions for the induction and assessed the effects of heat shock on C. elegans lifespan>as expected the worms are also transgenicyou're a teenager aren't you lol
>>76574304>he linked a paper that has ABSO-FUCKING-LUTELY NOTHING to do with chemical reprogramming
>>76574304here's the real science, lazy glowie disnfo bot:>https://www.embopress.org/doi/full/10.1038/s44321-025-00265-9>https://www.embopress.org/doi/full/10.1038/s44321-025-00265-9>Here, we demonstrated that chemical-induced partial reprogramming can improve key drivers of aging including genomic instability and epigenetic alterations in aged human cells. Moreover, we identified an optimized combination of two reprogramming molecules sufficient to induce the amelioration of additional aging phenotypes including cellular senescence and oxidative stress. Importantly, in vivo application of this two-chemical combination significantly extended C. elegans lifespan and healthspan.
Take roids. Its the hormone of the Gods, who are timeless beings.
>>76574370let's look at the chemical paperhttps://doi.org/10.1038/s44321-025-00265-9>so this two chemical cocktail is Tranylcypromine and RepSox>Tranylcypromine is a MAOI inhibitor and antidepressantlol good luck with that>RepSox is included as a part of some chemical cocktails intended for cellular reprogramming and anti-aging,[5] where it works by inducing the expression of the gene Nanog.[6]>I can guess where this is going, but lets see anywayhttps://doi.org/10.1002/stem.2007>NANOG, a key regulator of embryonic development and cellular reprogramming, has been reported to be broadly expressed in human cancers. Functional studies have provided strong evidence that NANOG possesses protumorigenic attributes. In addition to promoting self-renewal and long-term proliferative potential of stem-like cancer cells, NANOG-mediated oncogenic reprogramming may underlie clinical manifestations of malignant disease.lolbtw, worms aren't really very similar to humans at all, lets see if this these chemical cocktails has been used on mammalian cellshttps://www.biorxiv.org/content/10.1101/2025.06.25.661123v1.abstract>Harvard Medical School, seems reputable>human fibroblasts and mice>In tandem, we observed that treatment with both 7c and 2c causes a significant increase in lipid droplet formation in vitro, with 2c treatment having an even more pronounced effect compared to 7c treatment in fibroblasts.>When we treated male UM-HET3 mice with a low dose of the 7c cocktail for 28 days, we did not observe significant effects on kidney or liver transcriptomic age, overall gene expression, or on the expression of mitochondrial OXPHOS proteins. Higher doses of 7c, in contrast, led to a rapid loss of body weight and lowered body condition scores that required euthanasia
>>76574439Shit, I supplement multiple anti-depressant enzyme inhibitors for fun and upregulate multiple proto-oncoproteins in dermal fibroblasts just to grow more hair, but if you're some sorta low-tier chemo skills pussy who can't even meat tenderizer, by all means just age naturally, kek.
