Sup /fit/, a pretty massive new anti-aging discovery dropped, rivaling Schizo Yarmulke factors for maximum lifespan extension of mice, but only in males strangely...>Sex-specific longitudinal reversal of aging in old frail mice>https://www.aging-us.com/article/206304/text>We used an Alk5 inhibitor (A5i) of the age-elevated, pro-fibrotic transforming growth factor-beta (TGF-β) pathway that regulates inflammatory factors, including IL-11, and oxytocin (OT) that is diminished with age and controls tissue homeostasis via G-protein-coupled receptor and ERK signaling. Treatment of old frail male mice with OT+A5i resulted in a remarkable 73% life extension from that time, and a 14% increase in the overall median lifespan. Further, these animals had significantly increased healthspan, with improved physical performance, endurance, short term memory, and resilience to mortality. Intriguingly, these benefits manifested only in the male and not in the female mice, yet OT+A5i had positive effects on fertility of middle-aged female mice.I did a little upsream RNP on TGF-β and found...>An In Silico Study of Transforming Growth Factor-β Inhibitors: A Potential Target for Diabetic Nephropathy Treatment with Active Compounds from the Active Fraction of Physalis angulata>https://pmc.ncbi.nlm.nih.gov/articles/PMC11530946/>TGFβ1 Mediates Alcohol-Induced Nrf2 Suppression in Lung Fibroblasts>https://onlinelibrary.wiley.com/doi/full/10.1111/acer.12563>The potential of functionalized dressing releasing flavonoids facilitates scar-free healing>https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.978120/fullAnyone else looking at more papers with unusually long-lived mice than our favorite victim weight cryonics patient?>CAPTCHA:02KSM8
>>76666887try killing yourself
>oxytocin (OT) that is diminished with age>14% increase in the overall median lifespan> these benefits manifested only in the male and not in the female miceThere are longevity studies showing that eunuch men (and also several non-human animal species) have significantly increased longevity. I suspect that eunuch men have increased oxytocin. Semen retention, as taught in yogic schools, probably accomplishes the same.
>>76668003>There are longevity studies showing that eunuch men (and also several non-human animal species) have significantly increased longevity.You mean that big Korean study where the intervention group lived to like 71 and the matched control group to like 55? LOL.That kind of data is ack-shilly not too impressive considering the supposed "life extension" was barely to Hulk Hogan's age, kek.
>>76666904fpbp
>>76666887ty fren i like to keep abreast of this stuff but all the right info is swimming in an ocean of influencer shit and pharma shill hype
>>76669292The best shit is 100% buried in weird-ass journals found on Google Scholar that the influencer ain't talking about, like this new review on TGF-β in skin diseases...>Experimental Gerontology Available online 25 September 2025, 112900 In Press, Journal Pre-proof>Y. Zheng, J. Lei, A. Zhang, C. Cao, A. Xu, M. and Zhou, F. Lin, "Regulatory mechanisms of transforming growth factor-β in senescence of fibroblast associated with refractory skin diseases">https://www.sciencedirect.com/science/article/pii/S0531556525002293>Anti-aging treatment methods targeting the TGF-β signaling pathway have potential. Means such as drugs and phototherapy can regulate the TGF-β signaling pathway, inhibit ROS generation, enhance collagen synthesis, improve skin repair and elasticity. However, further research is needed on the interactions and clinical effects among anti-aging components to achieve more precise treatment strategies.protip: methylene blue plus zinc oxide as photodynamic agents are pretty S-tier for antiaging phototherapy
>Structural characterizations and anti-aging activities of a homogeneous polysaccharide derived from Coix seed-lactic acid bacteria fermentation>https://www.sciencedirect.com/science/article/abs/pii/S0141813025084363>The multiomics blueprint of the individual with the most extreme lifespan>https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00441-0>Comparative Evaluation of Extraction Methods for Scorias spongiosa Polysaccharides: Yield, Bioactivity, and Anti-Aging Potential>https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5520049>Pursuing healthy aging and longevity through natural product and stem cell-driven rejuvenation>https://www.sciencedirect.com/science/article/abs/pii/S0006295225006240>Phlorizin Ameliorates Amyloid-β Toxicity and Enhances Fatty Acid β-Oxidation in Caenorhabditis elegans via NHR-49-Dependent Pathway>https://www.mdpi.com/1422-0067/26/19/9303>Research progress on cell cycle arrest in dermal fibroblasts>https://www.tandfonline.com/doi/abs/10.1080/15384101.2025.2557240>Extraction, Characterization, and Anti-Aging Evaluation of Flavonoids from Citrus reticulata ‘Zhangshuensis’>https://pubs.rsc.org/en/content/articlehtml/2025/fo/d5fo02218e>Pharmacological Interventions for Aging and Rejuvenation: A Meta-Analysis of Clinical Outcomes and Anti-Aging Therapeutics>https://ojs.scipub.de/index.php/SR/article/view/6813>Betulinic Acid-Enriched Dillenia indica L. Bark Extract Attenuates UVB-Induced Skin Aging via KEAP1-Mediated Antioxidant Pathways>https://www.mdpi.com/2076-3921/14/9/1144>Endogenous Upstream Bioelectrical Modulation of Inflammatory, Angiogenic, and Anti- Senescent Pathways in Human Dermal Fibroblasts Using the REAC-ACT Protocol>https://www.researchsquare.com/article/rs-6701676/v1
