/fit/ - So, what do we know about selective PPAR agonists? - Fitness

Anonymous

10/26/25(Sun)22:22:08 No.76767385

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Anonymous 10/26/25(Sun)22:22:08 No.76767385 Archived

So, what do we know about selective PPAR agonists?
They're basically the holy grail of metabolism regulation, other than PPARd being carcinogenic (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291220)

Anonymous
10/26/25(Sun)22:25:07 No.76767389

Anonymous 10/26/25(Sun)22:25:07 No.76767389

>>76767385
https://youtu.be/s20ak4lYZmY?si=trF1oGqzoZTINreG

Anonymous
10/26/25(Sun)23:36:33 No.76767486

Anonymous 10/26/25(Sun)23:36:33 No.76767486

Bump

Anonymous
10/26/25(Sun)23:46:27 No.76767505

Anonymous 10/26/25(Sun)23:46:27 No.76767505

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>>76767385
>holy grail of metabolism regulation
2010 called, want their target protein back. It's FGF21 upregulators instead.

Anonymous
10/27/25(Mon)01:08:13 No.76767649

Anonymous 10/27/25(Mon)01:08:13 No.76767649

>>76767505
>FGF21 exerts its effects through PPARa and PGC-1a
Try again

Anonymous
10/27/25(Mon)01:19:53 No.76767663

Anonymous 10/27/25(Mon)01:19:53 No.76767663

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>>76767649
>PGC-1a
Funny-ass target to mention, considering >>76767150

So yeah, you into grow hair too, kek.

Anonymous
10/27/25(Mon)01:47:00 No.76767706

Anonymous 10/27/25(Mon)01:47:00 No.76767706

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>>76767385
New drug, whadda ya think?
>PPAR agonist
woho very nice. Thats cool bateman but thats nothing
>FGF21 upregulator
That is really super, how'd a nitwit like you get so tasteful
You ain;t seen nothin yet
>PGC-1a
Impressive, very nice. Lets see paul allens drug

Anonymous
10/27/25(Mon)12:12:25 No.76769025

Anonymous 10/27/25(Mon)12:12:25 No.76769025

Bump

Anonymous
10/27/25(Mon)12:19:16 No.76769039

Anonymous 10/27/25(Mon)12:19:16 No.76769039

>>76767385
There's a legitimate cancer risk inherent in all ppar-d agonists unfortunately that make them a non starter for me. I could see certain medical cases where the risk is outweighed by the reward.