Hey /fit/, we haven't had any good anti-aging threads in all the 38 year-old Aussie tren-trooning wogs recently, so... why did cold rich guy stop the autism pills and start looking more walled than China in 1644 A.D.? I think that's rhetorical and the answer is MOLECULE SKILL ISSUES. You don't have those, right /fit/?>Simple molecules make difference: short peptides play a novel role in slowing senescence>https://www.nature.com/articles/s41514-025-00292-3>Hot water extract of Punica granatum L. attenuates UVB-induced skin damage and enhances skin barrier function by regulating MKK–MAPK–AP-1 signaling>https://link.springer.com/article/10.1007/s10068-025-02051-2>Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia>https://link.springer.com/article/10.1186/s12951-025-03865-2>Time-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural Injury>https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5799533>Unleashing endogenous regeneration by senolytics>https://link.springer.com/article/10.1186/s12967-025-07398-y>Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Validation>https://www.mdpi.com/1422-0067/26/23/11394>Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging>https://pubmed.ncbi.nlm.nih.gov/41284871/>Citrus sinensis extract in skin aging: a comprehensive review of antioxidant, anti-inflammatory, and skin-health effects>https://www.tandfonline.com/doi/abs/10.1080/26895293.2025.2583064>Identification of active anti-aging ingredients from asparagus cochinchinensis based on the spectrum-effect relationship>https://link.springer.com/article/10.1186/s12906-025-05166-5Anyone else researching anti-aging better than le bl00per-print team?
Forced maymay
i've been having some skill issues too. supplementing magnesium glycinate, valerian root, and GABA to relieve chronic muscle tension (and stretching.. a lot). finally making progress. also, bought some basic bitch moisturizer to fix skin issues, after traveling twenty years into the future and observing that bryan still has nice skin even two decades from now.
>>76870565am i doin it rite?>picrel>>76870589>magnesium glycinate, valerian root, and GABA>moisturizerI do em all prophylactically, pretty good shit.>after traveling twenty years into the future and observing that bryan still has nice skin even two decades from nowI wish, but bro probably has to hire me for that but isn't ack-shilly rich enuf, kek.>The Nutrigenomic Effect of Mela Rosa Marchigiana Callus Extract on Cellular Senescence: Insight From a Preliminary In Vitro Study>https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.70336>Pterostilbene mitigates the senescence of human dermal fibroblast cells by enhancing mitochondrial quality>https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1732154/abstract>Anti‐Aging Activity of Rosa roxburghii Nano‐Emulsion in Caenorhabditis elegans: Preparation, Characterization, and Evaluation>https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.202502105>Preparation and evaluation of Dendrobium formosum extract-loaded microemulsions for anti-aging purpose>https://www.nature.com/articles/s41598-025-26252-1>Ginseng Oligopeptides Promote Longevity and Enhance Stress Resistance in Caenorhabditis elegans via the DAF-16/FOXO Pathway>https://www.mdpi.com/2076-3921/14/12/1390>Mendelian randomization and colocalization analyses reveal an association between diet consumption and altered telomere length in leukocytes>https://journals.lww.com/md-journal/fulltext/2025/11210/mendelian_randomization_and_colocalization.74.aspx>Sustained Activation of Nrf2 Antioxidant Pathway by Flexible Liposome Based on Low Phase Transition Temperature to Delay Skin Aging>https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202501696>Multi-target synergistic anti-aging: QG extends Caenorhabditis elegans lifespan through DAF-16/FOXO pathways, mitochondrial homeostasis and metabolic reprogramming>https://link.springer.com/article/10.1007/s10522-025-10347-3
How to reverse gray hair?
>>76870715>AI Overview - Prophylactically means preventively or protectively, particularly in the context of stopping a disease or infection before it starts.>have to use ai to understand your post and all that bullshit you linkedthank you, scientist
>>76870731
Ah cool another one of your threads. Hopefully there's something in vivo here.>Simple molecules make difference: short peptides play a novel role in slowing senescenceGood article, very informative. I hesitate that it's not peer-reviewed.>Time-Restricted Feeding Orchestrates Astrocytic Metabolic Reprogramming via the Wnt Pathway to Alleviate Sevoflurane-Induced Neural InjuryGrass is green, will keep Wnt in mind though. Again not ideal that it's a preprint.>Unleashing endogenous regeneration by senolyticsGood review, very informative about growth factors.>Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle agingExtraordinarily shitty conclusions and not open access.>Citrus sinensis extract in skin aging: a comprehensive review of antioxidant, anti-inflammatory, and skin-health effects>Identification of active anti-aging ingredients from asparagus cochinchinensis based on the spectrum-effect relationshipCool studies. ROS isn't the endgame for aging though.Peptides are probably the future, not small molecule polypharmacy.
So this is interesting..>Identification of AS1842856 as a novel small-molecule GSK3α/β inhibitor against Tauopathy by accelerating GSK3α/β exocytosis>https://pmc.ncbi.nlm.nih.gov/articles/PMC11709109/>The FOXO1 inhibitor AS1842856 triggers apoptosis in glioblastoma multiforme and basal‐like breast cancer cells>https://pmc.ncbi.nlm.nih.gov/articles/PMC9900086/>Transcription Factor FoxO1 Mediates Glucagon-Like Peptide-1 Effects on Pancreatic β-Cell Mass >https://doi.org/10.2337/db05-0825>Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice>https://doi.org/10.1124/mol.110.065714
>Arachidonic Acid Supplementation During Reproductive Aging Prevents Female Fertility Decline>https://www.mdpi.com/1422-0067/26/23/11332>Lysophosphatidic acid derivative is a novel candidate of therapeutic agents for a mouse model of frontotemporal dementia with progranulin deficiency>https://www.sciencedirect.com/science/article/pii/S0197458025002015>Broad Effects of Activation of Alcohol Dehydrogenase 1 on Healthspan Extension>https://www.biorxiv.org/content/10.1101/2025.11.23.687054v1.abstract>Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration>https://www.nature.com/articles/s41467-025-65426-3>A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo>https://www.nature.com/articles/s41514-025-00280-7>Luteolin Decreases Fat Accumulation and Extends Lifespan in Caenorhabditis elegans via DAF-16/FOXO and NHR-49/PPAR-α>https://pubs.acs.org/doi/abs/10.1021/acs.jafc.5c08997>ACE1-targeting peptide Acein ameliorates UV-induced skin damage and aging in vivo and in vitro via downregulation of the pro-aging factor CLEC4G>https://www.sciencedirect.com/science/article/pii/S000629522500807X>Transcriptomic insights into the healthspan-enhancing effects of C. chinensis seed and E. ulmoides bark extracts in Caenorhabditis elegans>https://link.springer.com/article/10.1007/s10522-025-10349-1>Effect of the novel senolytic drug, BCL-xL-PROTAC, on small airway fibroblasts in COPD>https://publications.ersnet.org/content/erj/66/suppl69/pa3533>Inhibition of senescence-associated β-Galactosidase by Amiloride in senescent airway epithelial cells>https://publications.ersnet.org/content/erj/66/suppl69/pa3529>A senolysis-targeting bioenergetic nanoplatform for diabetic wound healing>https://link.springer.com/article/10.1007/s42114-025-01509-5>>76870731Melitane Altris 5 *may* be better than the stuff B.J. uses, kek.
New whitepill just dropped bros...>Somatic mutations impose an entropic upper bound on human lifespan>https://www.biorxiv.org/content/10.1101/2025.11.23.689982v1.abstract>Our analysis reveals fundamental asymmetry across organs: post-mitotic cells such as neurons and cardiomyocytes act as critical longevity bottlenecks, with somatic mutations reducing median lifespan from a theoretical non-aging baseline of 430 years to 169 years. In contrast, proliferating tissues like liver maintain functionality for thousands of years through cellular replacement, effectively neutralizing mutation-driven decline. Multi-organ integration predicts median lifespans of 134-170 years —approximately twice current human longevity.>median lifespans of 134-170 years>"But but muh Chinese-Jewish bathtub lead meme pills r all snek oil scam!"
>Inhibiting a master regulator of aging regenerates joint cartilage in mice>https://medicalxpress.com/news/2025-11-inhibiting-master-aging-regenerates-joint.html>Blocking the function of 15-PGDH with a small molecule results in an increase in old animals' muscle mass and endurance. Conversely, expressing15-PGDH in young mice causes their muscles to shrink and weaken. The gerozyme has also been implicated in the regeneration of bone, nerve and blood cells.
>Reductive death is averted by an ancient metabolic switch>https://www.biorxiv.org/content/10.1101/2025.11.24.690166v1.abstract>Unveiling the Skin Anti-Aging Potential of the Novel Spirulina platensis Extract Elixspir®>https://www.mdpi.com/1422-0067/26/23/11372>Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine>https://www.nature.com/articles/s41514-025-00286-1>Late Breaking Abstract - Epigenetic reprogramming of pathological lung fibroblasts mediated by a repeat element-targeting oligonucleotide>https://publications.ersnet.org/content/erj/66/suppl69/pa5253>Enhanced liver regeneration via targeted mRNA delivery for partial in vivo reprogramming>https://www.biorxiv.org/content/10.1101/2025.11.03.686120.abstract>A novel strategy by pharmacological reprogramming reverses endothelial senescence and improves vascular regeneration>https://academic.oup.com/eurheartj/article-abstract/46/Supplement_1/ehaf784.4842/8307935>Transient pharmacological reprogramming reverses endothelial senescence and promotes vascular regeneration>https://www.ahajournals.org/doi/abs/10.1161/circ.152.suppl_3.4366240>Premature lethality by in vivo reprogramming results from oxidative stress-induced liver failure>https://s-space.snu.ac.kr/bitstream/10371/229089/1/000000190635.pdf
>An indole derivative of Ursolic acid, inhibits RANKL-induced osteoclast differentiation via modulating the Nrf2 and NFATc1/c-Fos axis: Targeting oxidative stress and osteoclastogenesis in managing rheumatoid arthritis>https://www.sciencedirect.com/science/article/pii/S0753332225009953>Discovery of anti-inflammatory compounds from the stem bark of Garcinia latissima through in vitro and in silico approaches>https://www.nature.com/articles/s41598-025-30017-1>Antioxidant, antimicrobial, and Anticancer Activities of Chemically Modified Pomegranate Peel Biomass>https://journals.ekb.eg/article_467325_0.html>Hepatoprotective potential of Salacia oblonga root against antitubercular drug-induced hepatotoxicity: An in vivo approach>https://www.sciencedirect.com/science/article/pii/S1878818125003871>Chemometric mapping reveals chemical, phenolic, and antioxidant profiles in Tanacetum polycephalum essential oils>https://www.nature.com/articles/s41598-025-25861-0>In Vitro Xanthine Oxidase Inhibition, DNA Protection, Anti-Inflammatory, Antioxidant Activity, Phytochemical Analysis, and In Silico Studies of Punica granatum>https://pubmed.ncbi.nlm.nih.gov/41289182/>Exploring the Active Substances and Mechanism of Physalis Calyx seu Fructus Against Inflammation-related Respiratory Diseases via Integrating Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry, Network Pharmacological Analysis, and Experimental Verification>https://pubmed.ncbi.nlm.nih.gov/41289163/>Characteristic Flavaglines with Therapeutic Potential for Ischemic Stroke from Aglaia perviridis>https://pubs.acs.org/doi/abs/10.1021/acs.joc.5c02308>Justicia procumbens promotes hair growth and ameliorates age-related deterioration of hair health>https://www.sciencedirect.com/science/article/pii/S0944711325012449>Computer assisted discovery of novel nicotinamide phosphoribosyltransferase agonists to combat muscle atrophy>https://www.sciencedirect.com/science/article/abs/pii/S0045206825011769
>Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State—New Directions in Anti-Aging Regenerative Therapies>https://pmc.ncbi.nlm.nih.gov/articles/PMC8228050/inb4 unc article
>Thymosin alpha 1: A comprehensive review of the literature>https://dx.doi.org/10.5501/wjv.v9.i5.67
Has anyone managed to shrink their amygdala with propranolol to reduce social/approach anxiety? If so what's your protocol? Do you take it daily or just when you feel anxious and how much? Are you not worried about adrenaline rebound between doses? Does it affect your gym performance?https://www.sciencedirect.com/science/article/abs/pii/S0006322321000470>Propranolol Decreases Fear Expression by Modulating Fear Memory Traceshttps://pubmed.ncbi.nlm.nih.gov/34534638/>Micro-injection of propranolol within basolateral amygdala impaired fear and spatial memory and dysregulated evoked responses of CA1 neurons following foot shock stress in rats
