Anything related to anti-aging, cognitive performance and physical performance enhancement through unnatural means. Share your stacks, discuss potent chemicals and post interesting studies.
None of you trannies take any of the substances you post, train/lift or even post progress pictures. Especially that one guy who keeps posting a long list with 100 vitamin and compound. You dont lift you dont train or consume any of those pills, you're just some sore loser trying to make a name in the cadaver of a misc wannabe board
>>76947589One of the most potent drugs (the most potent in experiments with model organisms) for preventing aging is aspirin. Its effects are manifold and include: reduction of systemic inflammation (primary function), reduction of thrombus formation, reduction of estrogen levels, and caloric restriction mimicry. A great deal of research has been conducted on it; for an introduction, you can review these articles:https://raypeat.com/articles/aging/aspirin-brain-cancer.shtmlhttps://haidut.me/?p=2760However, aspirin has 4 significant downsides:It increases gastric acidity and decreases the stomach's natural defense, which can lead to ulcers. This is not dangerous if gastric acidity is already low—and in such cases, it leads to improved digestion. This can be partially avoided by taking it in the form of enteric-coated tablets or with food.It increases bleeding and bruising. This cannot be completely avoided—therefore, aspirin intake should be avoided when anticipating situations where these might occur, but the effect can be reduced by taking Vitamin K.Slowed regeneration and growth of muscle and connective tissue. The effect can be reduced by taking aspirin after physical exertion—rather than before—as well as by counteracting it through the introduction of factors that enhance synthesis (Vitamin C, glycine).Permanent hearing loss due to the toxicity of an aspirin metabolite (salicylic acid) to the nerve cells associated with it. To remove salicylic acid from the body, it must bind with glycine, but this mechanism is limited by the availability of the necessary enzyme. One agent for the broadest spectrum of preventive effects (including some unique ones) is valproic acid, but theoretically, prevention can be achieved through a combination of many other substances; here I recommend questioning AI and deciding for yourself.
>>76947592>None of you trannies take any of the substances you postCope.
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>>76947620
Skincare:Morning 7x a week:CeraVe SA cleanserVitamin C serum, C12 La Roche posayNiacinamide 15%CeraVe Moisturizing SPFEvening 4x a weekCeraVe SA cleanserRedlight, Hooga panel Tretinoin 0.1%La Roche posay rich creamEvening 3x a weekSalicylic acid cleanserAzelaic acidLa Roche posay rich cream1x month:Dermapen with 36 inch needle cartridges. My skin at 30 after 5 months of this routine:Be sure to start with a lower tretinoin strength. Same with niacinamide.
>>76947589L-Ergothionine and L-Citrulline are underrated. I get better lifts and liver values thanks to them.
>>76947600Aspirin increases risk of bleeding too much to be part of your daily stack.
>>76947631Waay too much. The most basic skincare routine is sunscreen when you go outside, tretinoin a few times a week at night and face wash once a day or so.
>>76947631skins too soft. looks gay.
>>76947589>From Elixirs to Geroscience: A Historical and Molecular Perspective on Anti-Aging Medicinehttps://www.mdpi.com/1420-3049/30/24/4728>The multiomics blueprint of the individual with the most extreme lifespanhttps://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00441-0>Ageless Creatures: Molecular Insights into Organisms That Defy Aginghttps://journals.4science.ge/index.php/GS/article/view/3955/4004>Pursuing healthy aging and longevity through natural product and stem cell-driven rejuvenationhttps://www.sciencedirect.com/science/article/abs/pii/S0006295225006240
>>76947640Your blood still has ways to clot even with deactivated Thromboxane A2. Since i started taking aspirin daily bleedings are definitely more severe, like x1.5-2 of original blood-loss, but it's not x10 or anything close to lethal.
>>76947644Not too much at all. My skin handles it perfectly now. Never irritated or red. And quality has sky rocketed.
>>76947648Too much text and bs. Right now there are no existing therapies that can rejuvinate an entire mammal. Even the Yamanaka factor thing Bezos' company is researching can only rejuvinate certain organs. But we already to have medications like GLP1 and SGLT2i that can pretty much stop and reverse liver and kidney decline. It's the rest of your body and tissue that keeps declining and kills you.
>>76947645Post skin
>>76947653But it's bothersome and expensive to apply so much. You need to think long term with your routine after all.
>>76947655>there are no existing therapies that can rejuvinate an entire mammal. just workout and eat healthy
>>76947657True, it is bothersome. But I am disciplined so idc.
>>76947660That worked so well all the people from ancient times are still around...not.
>>76947631Impressive, very nice.
>>76947664Ancient retards ate meat cooked with fire which is very bad for health.
>>76947655>GLP1 and SGLT2i that can pretty much stop and reverse liver and kidney decline. How do they work? I thought ozempic are good for hunger prevention, not for liver and kidney immortality.
>>76947671SGLT2i make your kidneys piss out sugar instead of reabsorbing it which apparently is very good for kidney health.GLP1 (+ GIP + Glucogan) have different mechanisms by which they improve liver and kidney function, one major one ofc being slower digestion.t. latest blood tests show me having an eGFR of >140 which is insanely good. Was >120 in my early 20s before I started caring about my health.
>>76947678>SGLT2i make your kidneys piss out sugar instead of reabsorbing it which apparently is very good for kidney health.So, keto diet can achieve same effects. >one major one ofc being slower digestion.What's the connections between slower digestion and liver & kidney functionality and youthfulness? Can it lead to indigestion?
>>76947699>So, keto diet can achieve same effects.With keto you need to watch out for your apoB levels though which SGLT2i don't affect (as much).>What's the connections between slower digestion and liver & kidney functionality and youthfulness?I think pic related better explains some of the mechanisms behind each target.
>>76947589>Ghrelin, food intake, and botanical extracts: A Reviewhttps://pmc.ncbi.nlm.nih.gov/articles/PMC4587604/#abstract1
>>76947744>Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1https://pmc.ncbi.nlm.nih.gov/articles/PMC5078860/
>>76947749Sirtuins are a fucking meme. Only ITP mice studies are worth anything.
>>76947762>Sirtuins are a fucking meme.Why?
Bluepill me on methylene blue. What exactly it does in the body? What dosages are safe and effective?
>>76947637What dosages do you take?
>>7694779125mg and 6g respectively.>>76947782It's potentially good for brain health.
>>76947806We're still not sure whether microplastics actually do much in the human body. It's not ideal they are there but they aren't actively damaging like lead for example.
>>76947809>actively damaging like lead for example.Are there any known ways to completely remove accumulated lead and other heavy metals from body?
>>76947820Chelating agents like NAC potentially work.
>>76947822Good. I plan to consume it with morning coffee to remove heavy metals from it while retaining benefits from stimulation and polyphenols.
>>76947829NAC should be taken at high doses once a week at most. It's not kind on the stomach lining.
>>76947834
>>76947600Aspirin is a blood thinner and you also might be allergic to it. If for whatever reason one of u tards try this be careful with it
>>76947855600mg is nothing. I am talking about 10g+ per day which is significant.
>>76947871>Aspirin is a blood thinnerAnd here's why that's a good thing...
>>76947820Silica
I think its something with the environment making it too hard to live long. That being said I take most of the usual suspects and may start some peptides in a few years. I mainly want to keep my thymus in the best shape possible for as long as possible.
>>76947989HGH or rapa cycles apparently work for thymus growth.
>>76947969What facebook meme is this?
BadLuck Bryan MoleculeMogged>Therapeutic effects of Total flavonoids of Epimedium Folium on sarcopenia via modulation of gut microbiota and bile acid metabolism>https://www.sciencedirect.com/science/article/pii/S0531556525003304>Vitamin C is essential for proper myogenic differentiation>https://www.sciencedirect.com/science/article/pii/S0003986125004187>Ophiopogon japonicus Root Extract Attenuates Obesity-Induced Muscle Atrophy Through Regulation of the PI3K-AKT-mTOR/FoxO3a Signaling Pathway and Lipid Metabolism in Mice and C2C12 Myotubes>https://www.mdpi.com/2072-6643/17/24/3946>Consumption Trends in Science and Technology-Based Anti-Aging Products Among Oriental Women: A Systematic Review>https://d-sci.org/index.php/dsci/article/view/20>Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population>https://onlinelibrary.wiley.com/doi/full/10.1002/hsr2.71629>WGX-50 Promotes Healthy Ageing in Caenorhabditis elegans: A Combined Computational and Experimental Study>https://pubmed.ncbi.nlm.nih.gov/41414713/>Chemical Composition and Bioactivity of Nelumbo nucifera Gaertn. Flower Extract Fractions: In Vitro Antioxidant and Anti-Inflammatory Properties>https://www.mdpi.com/1467-3045/47/12/1065>In vitro and in vivo exploration of microbiome-derived yeast extract for anti-aging and skin rejuvenation>https://link.springer.com/article/10.1186/s12866-025-04593-1>Nanoscale Innovations in Essential Oils: A Comprehensive Review on their Efficacy against Skin Aging>https://link.springer.com/article/10.1007/s12668-025-02342-2>Chlorogenic Acid from Peucedanum japonicum Attenuates TNF-α-Induced Oxidative Stress and Inflammatory Damage in Human Dermal Fibroblasts>https://www.mdpi.com/2075-1729/15/12/1934>Gynostemma pentaphyllum-derived extracellular vesicles alleviate skin aging by destabilizing STING>https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5907208
>>76948061Study spamming indicates that everything on that list is a fucking meme.Ideally you post your favorite biohacking thing then go on to post studies in humans, animals and then mechanistic reasoning behind why it likely works.
i take collagen, vitamin c, vitamin d, magnesium, omega 3, nac, astaxanthin. use niacinamide on my face.
>>76948068Simple enough stack. Would switch to an omega 3 with EPA only and use a lower dose vitamin C supplement. Also NAC should be taken in high doses but less regularly and ideally together with high dose glycine.
>>76948061Can you describe your exact algorithm for finding and analyzing studies? You always seem to come up with new interesting stuff. My research skills are fairly lacking.
>>76948087nta but there are dedicated AIs for research you can use. Still, wouldn't exactly trust some dude who just spams studies. In most cases those are merely mechanistic studies (we've solved all diseases and aging in cell cultures already, <1% of that works in special model rats, <0.01% of that works in humans) or low quality studies funded by some shady supplement/equipment maker.
>>76947600Aspirin taken post-inflammation creates unique chemicals called aspirin-triggered lipoxins which decrease neutrophils activity and increases cellular debris-clearing activity of macrophages.
>>76948093>Still, wouldn't exactly trust some dude who just spams studies.I will try anything to achieve immortality, even magic.
koakuma my beloved
>>76947589/SCI/ANON CURES AGING, DICK SIZE, FINDS IQ HACK:The superdrug is called "Deferoxamine", also known as "Desferal" or "Desferrioxamine". By snorting it, it chelates non-metabolic iron from your brain and effectively gets rid of all the iron deposits due to aging, diseases, etc. Various diseases, like Alzheimer's, Parkinson's, Cancer, may be due to these iron accumulations.SIDE-EFFECTS: fungal sphenoid sinusitus (if you get double vision or paralysis after taking it, you may have that)SOLUTION TO SIDE EFFECT: snort 50-100mg of rapamycinhttps://youtu.be/1t3-TFBPpyshere's him talking about it: https://vocaroo.com/1hmJkw10q0ddhere's him talking about its side-effects: https://voca.ro/16YZO8vKvxFT and https://voca.ro/1cGYkb1jUY3oIncrease penis size using these chemical methods, supplements & vasodilators. This in parallel with the angion method = ridiculous dick gainshttps://www.researchgate.net/publication/322071346_Enhanced_Growth_of_the_Adult_Penis_With_Vitamin_D_3https://patents.google.com/patent/US20050065159A1/enANOTHER THING OF THE PAX PROTOCOL: Intranasal creatine:>oral creatine doesn't cross BBB ->intranasal does ->creatine gluconate is even better>THEREFORE: snort creatine for increased benefits.>it's also a potent antidepressant
>>76948102Yeah but trying out every meme thing at once risks injury and is a huge waste of money. I'd target the greatest causes of death in humans first which are cardiovascular disease (apoB and blood pressure), diabetes (SGLT2i, GLP1), cancer (various lifestyle factors), infections and accidents.
>>76947600Aspirin / eugenol can remove lipofuscin from cellshttps://haidut.me/?p=2178
>>76947706>you need to watch out for your apoB levelsHow to manage them?
>>76948113>diabetes Only retards have this. Literally just don't eat sugar and exercise.
>>76948119PCSK9i (very expensive) > statins (pitavastatin is the best one in terms of effect and low side effects but still reasonably priced) > bempedoic acid (expensive) > diet (low saturated fat intake) > ezetimibe (cheap)>>76948120If your genes suck you can do keto and still get full blown diabetes type 2.
>>76948061Anon, can you provide a quick briefing on Ca-AKG and Astaxanthin?
>>76947989>I mainly want to keep my thymus in the best shape possible for as long as possible.What's so special about this organ?
>>76948130CaAKG is a complete meme. It failed the ITP at the highest possible concentrations.
>>76948143Looks like research is still in progress.
>>76948143I hope there's some secret labs doing research on actual humans.
>>76947706Idiotic redditoid infographic.If you're lean and insulin sensitive avoid retatrutide
>>76948278Rude-retarded pepetide even mogged by damn vanadium, kek.
>>76948311Reddit retard truetide
>>76948061I wonder if there's a way to at least somehow predict if studies done on mice will translate to humans.
>>76948143How sure are we that mice have the same mechanism of aging as humans?
>>76947648I know for a fact you didn't read any of these.
>>76948767I don't care.
>>76948785Thats why you solved a caprcha to reply right
>>76948786I just like completing these small IQ tests.
>>76948130
>>76948811>Anticancer properties of sulforaphane: current insights at the molecular levelhttps://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1168321/full
>>76947892>600mg is nothingDon't forget that it compounds from cystein from food.
>>76947820Donate blood unironically, iirc siliva or some other compound can draw more of it into your bloodstream from your organs so the effect is greater.
>>76949000*silica
>>76948984*with cystein
>>76949000Extrapolating your data i conclude bloodletting after silica ingestion will work.
Raw meat is better than all of these meme supplements combined.And 90% of the time, the best supplements are substances that are already naturally present in raw meat.
>>76949000>>76949009https://pubmed.ncbi.nlm.nih.gov/35394514/>The mean level of PFOS at 12 months was significantly reduced by plasma donation (-2.9 ng/mL; 95% CI, -3.6 to -2.3 ng/mL; P < .001) and blood donation (-1.1 ng/mL; 95% CI, -1.5 to -0.7 ng/mL; P < .001) but was unchanged in the observation group. The mean level of PFHxS was significantly reduced by plasma donation (-1.1 ng/mL; 95% CI, -1.6 to -0.7 ng/mL; P < .001), but no significant change was observed in the blood donation or observation groups. Analysis between groups indicated that plasma donation had a larger treatment effect than blood donation, but both were significantly more efficacious than observation in reducing PFAS levels.Plasma donation is better than blood donation, but bloodletting would work too.
>>76949034>Raw meat is better than all of these meme supplements combined.Based colibactin enjoyer.
>>76949034Raw meat has too many bacteria that's why everyone normally cooks it
>>76949034Nome of the raw meat pushers on this board ever post body. Very telling.
>>76949034>>76949091Except combining a couple of those meme supplements can help treat the ass cancer u get from colibactin, kek.>https://mucpharm.com/
>>76949143You are one level above appeal to nature fallacy carnivore/keto idiots here. Your brain can not overcome mechanistic fallacy. I wanted to let you know your recent posts exhibit some grandiose delusions too. Please visit a psychiatrist.
>>76949135Joachim Bartoll, 51yo bodybuilder that follows a strict zero carb raw carnivore diet.https://bartoll.se/2025/11/nov-26-2025-update/Most raw carnivores do it for the health benefits, though, not to build muscle.
>>76949506He looks somewhat old and unhealthy.
>>76949506>Most raw carnivores do it for the health benefitsIt's interesting to see their biomarkers.
>>76949500There is no such thing as "appeal to nature fallacy" when it comes to health and biology.The appeal to nature fallacy was coined by a writer called G. E. Moore, who specifically stated it only applied to moral judgment and moral arguments.When you are talking about health, biology and the human body, you are talking about nature and appealing to nature in this context is a valid argument.If you deny the role of our natural environment in how it shaped our biology, you are essentially denying the theory of evolution.
>>76949522Thank you for demonstrating what I meant by "appeal to nature fallacy idiots" and happy holidays.
>>76949573So you deny the theory of evolution.
>>76949522If keeping your diet "all-natural" is really best, then why are lots of studies saying mice live longer when they are fed NAC, which is fully synthetic and only based on a natural amino acid?
>>76949767"Keep natural" is bullshit. There are plenty of ways to enhance yourself both for short term performance/looks and for longevity.Having saiid that, the human body is an extremely complex metabolic machine, which nature has put it to the test (or selected for fitness) for 200 thousand years.Trying to improve that with artificial means is at best like playing Russian roulette: if you do it very carefully and with proper research, you more likely than not won't fuck up. If you do so with broscience, that tends to be the equivalent of pistol-russian roulette.Natural isn't necessarily what's best for you, but it has been tested for 2 hundred millenia so it tends to work very well.
>>76949143Very interesting, thank you.
>>76948138One of the main parts of your immune system and starts shutting off/atrophying in most people around 30 and then you start having issues with t-cells and fighting off illnesses as you start to get older. People should be able to live much longer if their thymus did not fuck up.
