Active metabolite of Russian nootropic Noopept, cyclo-prolylglycine, acts as IGF-1 mimetic, increasing muscle and connective tissue growth by 10-15% in dosage of just 10mg. Glucose taken pre-workout significantly blunts cortisol response, preventing muscle catabolism. Trehalose, mushroom sugar, significantly improves health of blood vessels, one of the most susceptible to aging bodyparts.
>>77095888Source?
>>77095888>IGF-1 mimetic>not at least stacking GSK-3β and mTORC1 inhibitors>our foul year of the molecule skill issues (((2026)))
>>77096802>not at least stacking GSK-3β and mTORC1 inhibitorsCan you explain why you need to inhibit these? Doesn't mTORC1 boost muscle?
>>77096895>>77096895>Can you explain why you need to inhibit these? Doesn't mTORC1 boost muscle?Problem is chronic mTORC1 activation results in a gainz goblin feedback loop via induction of E3 ubiquitin ligases.>Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy>https://link.springer.com/article/10.1186/2044-5040-3-6GSK-3β is a str8 gainz goblin downstream of IGF-1, picrel.
>>77095888you fucking queers will do anything except lift heavy weights
>>77096951You'll lift all the way 2 Luigi syndrome without swole-ification if your proteins aren't in order.
>>77097013and what does this incel gibberish even mean?
>>77097033>and what does this incel gibberish even mean?Probably that you flunked AP bio and need to read:>The signaling landscape of insulin-like growth factor 1>https://www.sciencedirect.com/science/article/pii/S0021925824025493
>>77096802>>77096943>not at least stacking GSK-3β and mTORC1 inhibitorsSo, lithium boosts not only cognitive but physical gains too? I'm in!
>>77097040That's not the post I quoted, dyeltard
>>77097896>That's not the post I quoted, dyeltard>dyeltard so low-level chem skills they don't even know they're postin' in an IGF-1 bread>likely ain't even know it's a protein>doesn't know diet and exercise modulate said pathway irrespective of drugs>probably just inducing E3 ubiquitin ligases while getting bogged on hGH and staying smol like le Clav
>>77098044If you can actually read instead of copypasting shit from pubmed studies, I was asking about luigi-maxxing or whatever the fuck you were mumbling about.Its also fucking hilarious how you know all the biochem stuff but will never ever lift heavy fucking weights
>>77098047>luigi-maxxing>will never ever lift heavy fucking weightsLel yeah "Luigi-maxxing" is basically another term for the "caveman grug" approach to lifting of just progressively overloading the heaviest squats/deads you can until you hit the ortho office, kek.
>>77098047>hilarious how you know all the biochem stuff but will never ever lift heavy fucking weightsIt's hilarious how lean and jacked you can get from very moderate cardio and resistance training if you're on a ridiculously large, carefully selected supplement stack.
>>77098078Is this anon correct regarding lithium? >>77097190
What dose of cocaine would be a good preworkout without making your heart explode?
>>77098326Yup.>https://www.sciencedirect.com/science/article/abs/pii/S0165614703002062
>>77095888Fat, if taken with meat, inhibits upregulation caused by meat alone. >Ingestion of a lipid-rich meat matrix blunts the postexercise increase of myofibrillar protein synthesis rates in healthy adults: a randomized controlled trialhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12799377/This is the first study to characterize the anabolic properties of ingesting ground pork containing higher or lower amounts of lipids in healthy adults. Particularly, the production of a lipid-rich meat matrix is distinct from other protein-dense foods such as chicken eggs [10] and salmon [11]. Although the latter are naturally formed, the meat matrix is created by blending lean and fat trimmings to achieve a specific fat-to-lean ratio. Here, we demonstrate that ingestion of LFP leads to a more rapid and pronounced peak in plasma EAA and leucine concentrations, resulting in a greater stimulation of postprandial myofibrillar protein synthesis rates when compared with ingesting HFP and CHO. Moreover, the postexercise stimulation of myofibrillar protein synthesis rates did not differ between the HFP and CHO conditions, suggesting ingestion of a lipid-rich meal immediately postexercise may blunt the stimulation of muscle protein synthesis, potentially due to the blunted aminoacidemia (e.g., EAA/leucine Cmax) when compared with the ingestion of LFP.
>>77098424What dosages are good? Looks like they give 300mg to bipolars, do we copy?
OMMM chanting is something that actually does beneficial https://pmc.ncbi.nlm.nih.gov/articles/PMC3099099/
>>77098473Even less works apparently: https://www.mdpi.com/2073-4409/8/11/1340Also, many phytochemicals and other droogs have much higher potency though, such as Myricetin and Tideglusib.
>>77098506>Myricetin>Just get DNA damage and mutate bro
>>77098521From the same wikipedia...>Common dietary sources include vegetables (including tomatoes), fruits (including oranges), nuts, berries, tea, and red wine.Consumption of most of those (besides wine) have studies finding *decreased* cancer rates, so the kind of micromolar concentrations that act as GSK3-beta inhibitors can't be too dangerous.
>>77098705>>77098521>Just get DNA damage and mutate broQuick search pulled up this blog with some animal model studies claim it's ack-shilly *NOT* genotoxic in vivo at least to healthy cells, kinda like berberine:>https://focusontoxpath.com/genotoxicity-evaluation-of-the-flavonoid-myricitrin-and-its-aglycone-myricetin/
Why does it have to be occult foods and supplements and not just bare basic things that 99% of people aren't doing?>BRO I am totally doing that already!>Ew, I'm not doing that!Skip most supplements and just eat some rare beef liver.As a side note, anything good for better dreams? And does liver count as unusual? I never hear about anyone eating it.
>>77098899>anything good for better dreamsMake it colder where you sleep, if you want numerous and intense dreams. Cold air, that's it. But not so cold that you will wake up.
>>77098899>As a side note, anything good for better dreams?Galantamine.
>>77098715What's your opinion on permanent daily injections of BPC-157 and TB-500? Looks like they have different synergistic mechanisms of action aimed at connective tissue and don't bog you like ibutamoren and related compounds. Any possible side effects?
>>77098078But you're aren't lean and jacked, you're a fatty with bitch tits.
>>77095888>yeah bro, just microdose wabalaba dab dab and pin some cacafuti while popping three caps of homotesticuline instead of eating and liftingYou niggers are a fucking joke
>>77099547No one does it instead of eating and lifting. retarded nigger. There's just no interest in discussing lifting anymore because all the nuances of it are known already.
>>77099554(You) are a nuance. Go inject 300ml of hydrochloric acid into your balls bro, it boosts test.
>>77099522Those are pecs, stalker.
>>77096802What are some good mTOR inhibitors? I know you take some antiallergic drug but it also acts as anticholinergic and caused dementia, so i wonder if there's anything else comparable in effectiveness.
>>77100663The whole meclizine story has gotten a little muddled because it turned up in the anti-dementia research chemical literature due to different off-target effects:>Finding Drug Repurposing Candidates for Neurodegenerative Diseases using Zebrafish Behavioral Profiles>https://pmc.ncbi.nlm.nih.gov/articles/PMC10515830/Probably best to stay away from it for now if you're an old APOE4 carrier, but younger people who can remember which foods contain anti-dementia research phytochemicals are probably alright on low doses of it.I do some of picrel alternatives.
>>77095888Microdosing nicotine boosts cognition and slows aging. https://bioenergetic.forum/topic/9084/microgram-doses-of-nicotine-improve-the-nad-nadh-ratio-independent-of-the-acetylcholine-receptor.-....big-increase-in-neurogenisis-improves-inflamation-cognition-blood-sugar-and-anxiety.-triples-bdnf-and-causes-a-30-fold-increase-in-doublecortin
>>77100884I've been thinking about something recently. What if, instead of taking 1 stack of supplements daily, we will have periods of like 1 week once every 3 month where we completely switch supplement stack and diet to maximize autophagy and senescent cell clearance?
>>77102770I think that should mog because mTOR is what signals your muscles to grow. There are probably also further benefits to maxing out autophagy intermittently over having it at a constant level.
>>77096943>Problem is chronic mTORC1 activation results in a gainz goblin feedback loop via induction of E3 ubiquitin ligases.Guess what acts as mTORC1 inhibitor... Aspirin alchemists win again.
>>77102770Can anybody answer this?
>>77103873Why do you shill aspirin so much
>>77095888>Active metabolite of Russian nootropic Noopept, cyclo-prolylglycine, acts as IGF-1 mimetic, increasing muscle and connective tissue growth by 10-15% in dosage of just 10mg.checked. is this when taken before a work out? or does it matter when?
>>77098339half a line
>>77103873Have you tried lifting?
>>77098473you only need like 3mg-6mg for casual supplementation. Even if you get ConcenTrace® Trace Mineral Drops 1 dose has 1.5mg of lithium plus high quality micro minerals its a better option than electrolyte powders
>>77106414After workout is the correct timing.
>>77106246Because it's the best supplement in the world.
>>77106651Post body
>>77106741
>>77106741>>77106773>this *somehow* magically replaces reviewing PubMed articles to figure out if and how much aspirin is a good idea>because, of course, swole people always give good advice while DYELs and hamplanets never do /s>(((2026)))
>>77099251I cant confirm if this will make your dreams more intense. But I can confirm that when I dropped my house temperature from 70F to 63F my sleep improved drastically.
>>77095888Vitamin C megadoses inhibit aromatase.
>LLM schizo threadNo qualified human analysis was actually done for anything ITT, it's just a 15in arms dyel copypasting chatbot hallucination vomit everywhere
>>77107334It's not hallucinations.
>>77107334>>77107356If you prompt LLMs properly, you get a decent topic summary that might have an error or two; ask open-ended questions and you get abbreviated schizo slop, shrimple as.
>>77107334cope nigga, just deadlifted 500lbs and popped 3000mg vitamin c, and 10mg noopept and popped a zyn. Thanks OP
>>77107442Many people say AI tends to always agree with you but for some reason i always have to push AI to come to correct conclusions.
