—CLASSIFIED FILES—EXPERIENCED ALCHEMISTS ONLYI was researching techniques of brain rejuvenation, the most important and difficult of anti-aging procedures. I discovered class of drugs named Antileukotrienes, used by ordinary people for treatment of asthma. What they do is antagonize leukotrienes, inflammatory metabolites of PUFAs, either by blocking their receptors or preventing their synthesis. Brains are highly prone to inflammation and aging because of their high PUFA content which is easily oxidized, creating inflammation and DNA damage. When researchers tested drug of this class called Montelukast on naturally aged rats, they 100% rejuvenated their brains to younger state. >Old rat brains rejuvenated and new neurons grown by asthma drughttps://www.newscientist.com/article/dn28384-old-rat-brains-rejuvenated-and-new-neurons-grown-by-asthma-drug/>Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drughttps://www.nature.com/articles/ncomms9466This drugs seems to have other purposes, and is not researched for Alzheimers treatment. I found site when repurposing of this drug for different aliments is discussed: https://www.montelukast-repurposed.org/During analysis of the drug's risk profile, i found there was some kind of hysteria about adverse psychological effects similar to PFS, and the only real side effects are slightly elevated anxiety, sleep disturbance and tics, basically similar to coffee, which is caused by increased dopaminergic tone due to CysLT1R antagonism which is protective for dopaminergic neurons. Recently there was a follow-up on Danazol (Drug with most complex pharmacology in AAS class) treatment for telomere-related disorders that can be used as a model of fast aging of whole organisms. >Danazol treatment for telomere biology disorders - long-term results of a phase 1-2 studyhttps://ashpublications.org/bloodadvances/article/10/1/208/547849/Danazol-treatment-for-telomere-biology-disorders
>>77149760Also, there's another drug of antileukotriene class, named zafirlukast, that has metabolite which is potent converter of white fat to brown fat. >Drug-Initiated Activity Metabolomics Identifies Myristoylglycine as a Potent Endogenous Metabolite for Human Brown Fat Differentiationhttps://pubmed.ncbi.nlm.nih.gov/36005620/
>>77149772Imagine combining it with mirabegron...>Mirabegron, a Selective β3-Adrenergic Receptor Agonist, as a Potential Anti-Obesity Drughttps://pubmed.ncbi.nlm.nih.gov/37959362/Mirabegron, a selective β3-adrenergic receptor agonist, has been found to be effective as a brown adipose tissue activator, a "beige" cells stimulator and a metabolic homeostasis controller in animal and human studies.
>>77149760>and is not researched for Alzheimers treatment. now* researched
Drug addicted DYEL trannies thread
>>77149793Uneducated tranny addict, begone.
>>77149796How about you educate some muscles on your frame tittyboy
>>77149803I'm extremely muscular and don't even go to the gym.
>>77149760What do you think there is to hack?
>>77149866Everything.
>>77149870What are you improving upon?
>>77149875Youthfulness, muscle mass & strength, cognitive abilities, appearance.
>>77149878But what are you hacking to achieve that? How do you know what you're hacking/improving on biology's original design, and how do you know what you're just fixing that's broken from our modern way of life?
>>77149903>But what are you hacking to achieve that?Dutasteride is a good example of biohack for mainly appearance purposes with good side-effects relating to health and cognitive abilities. >How do you know what you're hacking/improving on biology's original design,I have very high data search and analysis skills.
>>77149907>I have very high data search and analysis skills.Can you give an example how you improve on certain molecular mechanisms? I'm curious what you've come up with.
>>77149903He looks like this >>77149823 if you did too, you'd also be clinging onto everything to try and look normal including weird drugs
>>77149914>Can you give an example how you improve on certain molecular mechanisms?Developed this drug combination recently as a means to significantly raise free T without side effects. Posted it on peatards forum but they neglected it because muh DHT.
>>77149928No I mean the molecules. I'm not talking about more testosterone or less testosterone, I'm talking about if you've come up with a better molecules themselves.
>>77149941No, i don't care about developing new molecules.
>>77149945Ok but what are you improving about the existing molecules?
>>77149952Are you retarded?
>>77149954Yes please explain to me like I'm a retard. What are you hacking?What is the original biological design, how is it flawed, how are you improving it?
>>77149963I'm not developing or modifying drugs, i use existing ones for desired outcomes, and i already gave you examples of that.
>>77149968No I'm not talking about drugs, let me give you an example.So ATP is the fuel the body uses for basically everything right? And if you want more energy, you want more ATP, or make it so ATP gives more energy per molecule than it does now. And hormones and shit themselves are not a source of energy, they are more like grocery lists that decide what molecules go where. So if you're just increasing levels of a hormone, you're not hacking biology to get more out of the molecules it uses, you're just increasing the numbers on the grocery list. You're just saying "put more molecules here", you're not getting more out of the molecules. So what do you think hormones are doing wrong in their job of telling which molecules to go where, and how are you improving on their design?
>>77149987>So if you're just increasing levels of a hormone, you're not hacking biologyI'm not going to argue about semantics.
>>77150001You won't have to, if you can give some concrete biomechanical examples like in the animation I provided, or this one.What are these things doing wrong that you are fixing?
>>77150007>concrete biomechanical examplesAspirin-triggered lipoxins.
>>77149760based /x/fit/ crossover
>>77149760he cracked the fuckin code, OP will kill himself with 3 gunshots to the head
>>77149916He looks good tho.
>>77149760Biojew-kun, do you leverage the pathway of leukotriene inhibition?
>>77149760bump
>>77150224>HeBad samefagging attempt
>>77149760Asthmatic bro here, this thread might just have convinced me to start taking my asthma meds(montelukast and aerius) with regularity again. After i went through puberty i only took them while having an allergic reaction.
>>77150800Probably should just take montelukast since aerius has anticholinergic action which may lead to dementia symptoms long-term.
OMMM chanting, those monks were onto something they weren't saying OMM for no reasonhttps://pmc.ncbi.nlm.nih.gov/articles/PMC9015091/
bump
The montelukast thing is very cool, keeping an eye on that one.I'm getting varicose veins in my early 30s so I've been researching that. My latest quest is arterial and vascular health, and improving my cardio. Interested in restoring endothelial function. Where are you guys getting Cialis for cheap? Any other recommendations for venous insufficiency? I refuse to accept that the answer is just compression socks and elevating my feet until I die
>>77149760Anecdotal info weighing in on montelukast: I believe what OP posted is true. I’ve been taking montelukast since I was a kid (late 30s now) and have never experienced a slowdown in my ability to learn or assimilate new information. The adverse psych effects stuff is totally overblown as OP stated. The drug had to have a warning label about depression at one point iinm, but I’ve never experienced that.
>>77151825>My latest quest is arterial and vascular health, and improving my cardio. Interested in restoring endothelial function.You should research telmisartan. It's a very popular blood-pressure management drug among bodybuilders and athletes, because it lowers myostatin, upregulates/agonizes PPAR gamma receptors and to some extent prevents heart hypertrophy. It's very protective for vascular system and kidneys, one of the reasons being upregulation of anti-aging protein klotho. I'm not completely sure if it will 100% reverse your condition, but it will stop progressing. >Telmisartan improves vascular remodeling through ameliorating prooxidant and profibrotic mechanisms in hypertension via the involvement of transforming growth factor-β1https://pmc.ncbi.nlm.nih.gov/articles/PMC5646990/>It was found that telmisartan attenuated chronic vasoconstriction and oxidative stress in the SHRs, and improved vascular reactivity. Telmisartan also restored vascular pathological alterations and decreased collagen deposition.Also, maybe consider pitavastatin to decrease load on cardiovascular system even further.
>>77151825I've looked into your condition further, and it seems metalloproteinases, connective tissue degrading enzymes, are heavily involved. >Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Diseasehttps://pmc.ncbi.nlm.nih.gov/articles/PMC4658486/In this case you should consider antibiotics doxycycline/minocycline. They both heavily inhibits mettaloproteinases and improve endothelial function. Interesting detail about minocycline is that it's antileukotrienes like montelukast, but instead of receptors antagonism in inhibits enzyme that leads to formation of leukotrienes. I haven't assessed minocycline risk profile yet, doxycycline is safe.
>>77150720>>77150976>>77151228
>>77151983Cope.
>>77151951>>77151979Wow, took a nap and now I'm back, thanks for the great intel. Reading about MMPs, interesting stuff.
>>77149793If you aren't taking any drugs in 2026 you're clinically retarded.
>>77151979>Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cellshttps://www.cell.com/article/S2213-6711(14)00199-4/fulltextWe here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance.
>>77149760Opinion on muscimol? Looks like it's a potent nootropic, but i never heard anyone talking about it here.
>>77149760Delta-sleep-inducing peptide may be a potent anti-aging compound, and it has been tested by one anon here for sleep problems. >Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR micehttps://www.sciencedirect.com/science/article/abs/pii/S0047637403000824?via%3Dihubit slowed down the age-related switching-off of estrous function; it decreased by 22.6% the frequency of chromosome aberrations in bone marrow cells; it did not influence mean life span; and it increased by 17.1% life span of the last 10% of the survivors and by 24.1% maximum life span in comparison with the control group. We also found that treatment with Deltaran significantly decreased total spontaneous tumor incidence (by 2.6-fold), mainly mammary carcinomas and leukemias in mice as compared with the control group. This is the first report on geroprotector and anticarcinogenic effect of DSIP-containing preparation Deltaran.
>>77149760Post body.
>>77149760
>>77153350Already posted >>77149823
>>77153353Why you keep spamming this BS?
>>77153358Yeah that explains it.
>>77152544You're a junkie
>>77149793post physique>>77149823good boy?
>>77153382I take drugs that both make me feel good and are actually good for my health. If you don't do the same you're just have too low IQ to understand pharmacology.
>>77153387I dont need exogenous substances because im not bitchmade. The drugs are making you grow nice titties btw you're sure you're not transitioning ?
>>77153394>I dont need exogenous substances because im not bitchmade. No, it's because you don't have ambitions to surpass humanity like i do.
>>77153397Sit down boy you look like you have klinefelter i dont think you'll even reach human status to surpass it
>>77153406I mog you, goy.
/fit/'s highest-tier molecule wizard here, checking in with the latest schizo-tier Asian cell assays...>Picalm Coordinates Clathrin-Mediated Endocytosis And Actin Remodeling During Myogenesis>https://www.sciencedirect.com/science/article/pii/S2212877826000359>A Systematic Review and User Reference of Phenotypic and Molecular Characteristics of Dexamethasone‐Mediated C2C12 Muscle Atrophy>https://onlinelibrary.wiley.com/doi/abs/10.1002/jcsm.70127>Myogenic induction activity and mechanism of rhein in aged mouse myoblasts C2C12 cell line>https://shkqyx.magtechjournal.com/EN/Y2026/V35/I1/19>Stevia Extract Improves Skeletal Muscle Metabolism and Mitochondrial Function While Attenuating Muscle Atrophy in Palmitate-Treated C2C12 Myotubes and db/db Mice>https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.70425>C-peptide promotes myogenic differentiation in vitro and low serum levels are associated with sarcopenia in adults and the elderly>https://link.springer.com/article/10.1186/s12967-026-07983-9>Asperuloside Protects Against Age‐Related Muscle Dysfunction by Enhancing FOXO3‐Mediated Mitophagy>https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.70297>Icariin Improves Metabolic Response to Exercise by Promoting TFEB-Dependent Mitochondrial Clearance and Metabolic Re-programming in C57BL/6 Mice and C2C12 Myotubes>https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1754850/abstract>Yeast Chronological Lifespan Model as a Tool for Screening Aging Interventions>https://www.mdpi.com/1422-0067/27/6/2633>FXR maintains primordial follicle dormancy via regulating FoxO3 expression >https://academic.oup.com/reproduction/advance-article/doi/10.1093/reprod/xaag031/8516576>Anti-aging effects of rare prosaikogenin F from microbial biotransformation of saikosaponin A>https://www.sciencedirect.com/science/article/pii/S0367326X26000936
>>77153409What's your opinion on danazol? Is this drug the best we currently have for prevention of aging-related DNA alterations, or are there potentially better genome-stabilizing agents? I remember you posted a study once that said DNA-mutations are the actual longevity handicap, so we should address it as early as possible.
>>77153382>>77153394Said the tech junkie
>>77153409>>77153421Post physique
>>77153409You should really look into antileukotriene drugs for brain rejuvenation.>Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonisthttps://pmc.ncbi.nlm.nih.gov/articles/PMC4114018/5-Lipoxygenase as an emerging target against age-related brain disordershttps://sci-hub.pl/https://pubmed.ncbi.nlm.nih.gov/33984528/
>>77153409Haven't knew dexamethasone is such a gains-goblin.
>>77149760>Blood levels of 'free range' DNA may signal early detection of dementia and frailtyhttps://medicalxpress.com/news/2022-10-blood-free-range-dna-early.html
>>77153409>Scientists Successfully Transfer Longevity Gene, Paving the Way for Extending Human Lifespan>https://scitechdaily.com/scientists-successfully-transfer-longevity-gene-paving-the-way-for-extending-human-lifespan/Do you think we can replicate it with hyaluronidase inhibitors, like ascorbyl palmitate?
>>77153435>>77154277Meaningless tranny wordsYou all look dyel and will die at 70 like everyone else
>>77154283It will be so fun to mog retards like you when i will completely retain my youthfulness in old age while your body crumbles under multiple chronic diseases. Part of the reason why i'm doing it, in fact.
>>77154295Two more weeks
>>77154302More like 50 more years... Still worth it.
First off, I will always recommend that people avoid instigating the inflammatory state in the first place rather than trying to treat it by interfering with drugs.Anything that has neurological effects is hazardous at best and dangerous at worst, unless you specifically know your issue; at which point in the metabolism of ATP production you have a deficiency or with which neurotransmitter you're deficient in, it's just not too worth doing. Some more mild nootropics that have a benign to almost positive effect are good to try out.https://pubmed.ncbi.nlm.nih.gov/39836401/https://pmc.ncbi.nlm.nih.gov/articles/PMC9415189/Main things I can recommend;Do a sleep study at least once in your life, follow-up if you have issues that are in the course of treatment.Maximize your restful sleep. I cannot stress enough how important good sleep is over ANYTHING ELSE. Odds are, if you're experiencing chronic progressive and unexplainable symptoms which affect your energy, you're likely experiencing the consequences of chronic sleep deprivation/deficit (probably for several years if they are manifesting only now/recently) https://pmc.ncbi.nlm.nih.gov/articles/PMC8894343/There's a ton of causes for generalized symptoms:Black mold exposure, cancer, chronic inflammation from infection, parasites, undetected food allergies, etc etc.Most common one is poor sleep and food allergies.
>>77154313>Anything that has neurological effects is hazardous at best and dangerous at worstNo, you're just afraid to use effective drugs that actually work and change your biology because you have genetically overreactive amygdala. Many such cases. >>https://pubmed.ncbi.nlm.nih.gov/39836401/>Montelukast Use and the Risk of Neuropsychiatric Adverse Events in ChildrenYou definitely wanted to post it as a proof of dangers of montelukast. Let's look into it>In this large study of children and adolescents based on data from routine clinical practice, there was no association between use of montelukast and the risk of neuropsychiatric adverse events. Fucking retard, you don't even read articles after the title.
>>77154277>ascorbyl palmitateWill mostly be broken down by esterases in digestive tract if administered orally, but other compounds can be effective.
>>77154305I will laugh at you castrating yourself for no results
>>77154356In the 80's you would be one of the retards believing steroids don't actually bring results, kek.
>>77154333idk man you speak with hate and vitriol. I just posted shit to discuss. I like that you skipped the context of the part after where I said "unless you specifically know your issue" where it's more effective to first understand your deficiency and then treat that as you will get minimal unwanted effects. The human body is amazing and most anything can be accomplished with a normally functioning brain, as long as you're willing.I understood the article stated that montelukast has no association with "neuropsychiatric adverse events" and I posted it anyway. I wasn't making a direct argument against your post specifically.Did you also skip the article I posted where it states that nootropics are generally good and used for treatment of brain injury and loss of cognitive function?It is generally advisable to not treat yourself for things you don't have is all. Much better to avoid inflammatory interactions rather than fight them. Not to mention taking nootropics which enforce the creation of neural pathways and behavior associations and then just procrastinating instead of actually doing something productive and habit forming (the good kind).It's like drinking electrolyte concentrates for office work, sure you're gonna be hydrated but your kidneys will have crystal deposits in them by week 3.
>>77154372I didn't read your chatjeet-pt drivel btw have fun castrating yourself brah while i reap mad gainz from just sleeping properly and eating food and i WILL outlive you efortlessly
>>77154372>>77154642Here's some more Jeet-PT on why they don't work very well for like 70% of Burgers with genetics and epigenetics skill issues.
>>77154648Yeah i aint reading allat sorry you're upset brah
>>77149760The most esoteric /fit/ knowledge of all:Eat well, drink enough water, sleep a lot, lift hard or just train hard in the sport you like
>>77154642>i reap mad gainz from just sleeping properly and eating food Nattytard daydreaming.
>>77154633>it's more effective to first understand your deficiency and then treat that as you will get minimal unwanted effects.You will never surpass humanity if you do biohacking from position of "removing the deficiencies" and not from position of advancing current boundaries of your biology. >Much better to avoid inflammatory interactions rather than fight themLook up "systemic inflammation" and "Senescence-Associated Secretory Phenotype (SASP)". Everyone has some level of inflammation due to factors that are impossible to avoid.
>>77154648Where does it say 70% of Burgers have this mutation? Would be pretty insane if true.
>>77154684No bro you dont get it how else will ching yilong zapato and ivanovski vodkalovaski get their monthly paycheck if im not spending hundreds on meme mystery injections and pills to convince myself im no different than the average roidtranny except im still dyel and will also die early due to liver failure
>>77149760Can anyone eval my nootropic stack? it's a very normie stack but I've been looking to improve it as I've been trying to grind up the SWE job ladder.Daily:Creatine 10mgVit D + K2200mg Caffiene 100mg L-Theanine300mg Alpha GPC500mg L-Tyrosine300mg Omega 3300mg Magnesium Glycinate Pre-Workout:3,000mg L-Citrulline DL-Malate 2:1 PowderOccasional:Gorilla Mind Smooth when Idk i feel like i need something more.Should I change my daily doses on any of these? Add something else? Been looking towards Lions mane or asian Ginseng. Open to more novel/exotic recommendations if they're truly effective and are worth the side effects.
>>77154817GarbageDrink orange juice and eat a banana before workout and you're good
>>77154817>500mg L-TyrosineI'd swap it out for Astaxanthin or something else, lmao.>Popular brain supplement linked to shorter lifespan in men>https://www.sciencedaily.com/releases/2026/02/260226042458.htm
>>77154817>Can anyone eval my nootropic stack?Not bad basic stack.>Open to more novel/exotic recommendations if they're truly effective and are worth the side effects.You can consider: Citicoline ALCARGalantamine
>>77154834Onii-chan can you notice me... >>77153420>>77153420>>77153420
>>77154820Not all of us are on gas station boner pills and trt at 30 like you are retard, stop polluting this thread and go back to /cbt lusting over fake female cbt posts.
>>77154834>https://www.sciencedaily.com/releases/2026/02/260226042458.htm>Tyrosine is also involved in producing stress related neurotransmitters, which may influence metabolic and hormonal pathways differently in men and women.Kek, is that how they call dopamine and norepinephrine?
>>77154858Every single substance posted itt can be accurately described as a gas station or bathtub pill yes. You're all transgender.
>>77153420>>77154849Danazol looks at least *promising* as an anti-aging therapy, but it is very hard to say if it's the best hTERT inducer out there. Picrel clanker is right that binding data is missing on most of the plant-drived ones, such as fisetin which it forgot, so a conclusive answer will have to await more research.
>>77154834>>77154840appreciate the suggestions thanks y'all.
>>77154865Why did you enter the thread
>>77154885He's a seething nattytard.
>>77153099Ive tripped on it once or twice. Masturbating feels amazing on it and the sleep is great too. Slightly neurotoxic though, dont do it too often
>>77153420>>77154874Picrel outlines some alternative strategies beyond hTERT induction for reducing somatic mutation r8z.
>>77153099yup i agree with >>77154891, even with stoners/mushroom abusers a very common anecdote shared around is that you definitively need rest between mushroom trips to actualize mental/spiritual gains, mushroom abuse definitively leads to retardmaxxing.
>>77154874>Hypoxia-inducible factor 1αWhat do you think on progressively training box breathing as anti-aging technique? When you start at 4 seconds and day by day increase time between each step.
>>77149760Desloratadin and L-Ergothioneine are my uncommon yet highly beneficial supps/meds I'd recommend.
>>77153409Not fisetin schizo again.General rule of thumb, if your post contains more than three substances or more than three studies, you're a schizo.
>>77154955I respect the russian schizo more than him since he at least has balls to post his physique and face (even uncesored, stupid but bold and commendable)That cuck will never post physique because he's a flabby DYEL in his 40's
>>77154947What benefits have you noticed from ergothioneine?
>>77154978Liver enzymes went way down and my aerobic performanced increased by a fair amount.
>>77149760>I'm going to le hack le biology>uuuhhh, STEM degree? what's that?>uuuhhhhh, biochemistry? never heard of it >yah bro I totally know how everything works in the human body>trust me bro, I'm really good at using chatGPT>sorry, no, never been to this "laboratory" thing, what would that have to do with biohacking anyway?
>>77154994>this negroid needs STEM degree to make roids work
>>77154992Good stuff. i just wanted to add something for liver protection to my stack. What dosages do you recommend?
>>77149760Not brain shit but I got fed up being stuck at 195 after losing 100-ish pounds. Went back and read up on the croissant diet and upped my sat fat and calories, gunning for roughly 120-150g of fat a day. Suddenly lost about 10lbs then hit another plateau. Found brad's post about succinate/R-ALA supplementation and started that and it's crazy, another 10 melted off and I'm down to about 13.5% bodyfat without any changes. I *was* doing addl cardio but cut out cardio completely except for two days a week and biking to and from the gym and I'm reliably gaining strength every workout now too (HIT, before anyone says anything). Not sure on the specifics but if you have a post-obese metabolism like I do, your bodyweight set-point is high which explains why I could fast down to the 180s but float back up into the 190s even though I thought I was en-pointe in regards to diet. Still have 4lbs I want to lose to see my abs but after that I'm curious as to whether or not the weight will stay off.Succinate: https://fireinabottle.net/succinate-increases-athletic-performance-by-oxidizing-nadh/R-ALA: https://fireinabottle.net/pro-oxidants-make-you-lean-antioxidants-make-you-fat-sometimes/He also reccomends sterculia oil or pu-erh tea for SCD1 gene attenuation but I'm having good results with basic bitch succ/R-ALA so far.Fucking insane I was nuking my metabolism doing lean carnivore for 2 years when I should've been upping fat and letting the process work itself out.
>>77155002Interesting, thank you for sharing.
>>77154955>General rule of thumb, if your post contains more than three substances or more than three studies, you're a schizo.I'll let you in on a serious protip: thousands of supplements and RCs work for anti-aging, yet none of them work very well individually.
>>77155032Since we're literally going full schizo-tier now, why not check out...>J Orthomol Med, 2009>The Adrenochrome Hypothesis of Schizophrenia Revisited>https://isom.ca/wp-content/uploads/2020/01/JOM_1981_10_2_04_The_Adrenochrome_Hypothesis_of_Schizophrenia_Revisited.pdf>t. smart enough to make it from an Epi-Pen AND not take it.
>>77154834So we need to avoid methionine, leucine, cysteine AND tyrosine now? Wtf?
>>77155058Full schizo-tier is that guy who used apigenin for yarmulke activation. https://rentry.co/CR_GeneralI wanted to talk to him and then discovered he's literally hobo now, living at Salvation Army shelter with other insane hobos beating him. It's hilarious. https://youtu.be/j8NKIk3i-fM?t=37
>>77155122Kind of hilarious and sad at the same time seeing him argue with fellow crippleschizos at the tard house; he was sort of on to something (picrel) but way over-hyped the effects.You'll learn more reading this paper Dr. Sinclair co-authored last year (such as GSTA4 being a "Yamanakalog" enzyme):>https://www.biorxiv.org/content/10.1101/2025.08.30.673239v1.abstract
>>77155137>You'll learn more reading this paper Dr. Sinclair co-authored last year (such as GSTA4 being a "Yamanakalog" enzyme):Very interesting, thank you.
>>77149760EX-597 is the ultimate drug for cognitive gains. It inhibits enzyme that breaks down anandamide.https://en.wikipedia.org/wiki/EX-597
>>77151979>>77151951Can you help with varicocele on left testicle? I feel I have like a bag of worms there, also my balls are huge but I get normal morning woods everyday and I’m still horny, when I lay down they disappear so I don’t think it’s cancer. What do?
>>77155220Looks like palmitoylethanolamide can achieve similar effects by reducing FAAH expression, and it's easier to get.
Not gonna lie getting rid of my stress was more effective than any supplement I've taken. Stress has effected my body on every level
>>77155220>>77155269>Identifying FAAH Inhibitors as New Therapeutic Options for the Treatment of Chronic Pain through Drug Repurposinghttps://pmc.ncbi.nlm.nih.gov/articles/PMC8781999/Sometimes i'm starting to think universe is biased in my favor.
>>77153409Are you planning to do gene therapy to increase follistatin production like Bryan Johnson?
>>77149823>biohacked himself into having bitchtitsimpressive, very nice
>>77149760>Lipoic Acid Saps Methyl Groupshttps://chrismasterjohnphd.substack.com/p/lipoic-acid-saps-methyl-groups
>esoteric>recommends pharma kike suppsthink you misunderstand the meaning of esoteric. it is that which is hidden. meaning, all things on earth originate from dirt thus the esoteric aspect is figuring out which effective shaman chems derive from GOD created plants>in muggle OP case>antileukotrienesfound in grapes. gee golly that was hard. its almost like a real esoteric schizo /fit principle was>the color of the food = chakra region it fixesgrapes are purple, the third eye is purple and controls head organs, magick.>but wait, theres morechakras are inversely connected. the third eye is an inverted sacral chakra. this means the giga esoteric secret is fix sacral to unlock fixed third eye. in this case the pharma kike chem ‘antileukotrienes‘ are also found in citrus fruits (orange = sacral) and naturally produced in the … … gut, which the sacral is home to … aka ‘gut feelings’ connected to ‘sixth sense’>OP is a muggle that needs to lurk more
>>7715500125-30mg
>>77156514What makes a man cope with such nonsense?
>>77153409Interested on your honest opinion on palmitoylethanolamide. Seems like very interesting and somewhat unique compound, easy to get large amounts too.
>>77149760Found this useful website that can calculate whether a substance can penetrate BBB or not. http://bbbper.mdu.ac.in/
>>77149760>Peroxynitrite-Induced Nitrotyrosination of Proteins Is Blocked by Direct 5-Lipoxygenase Inhibitor Zileutonhttps://jpet.aspetjournals.org/article/S0022-3565(24)29318-6/abstract
Rate my drug stack1 mg Tirzepatide 5 mg Cialis 1 mg Pitavastatin 20 mg Telmisartan 60 mg Testosterone Undecanoate50 mg NandroloneI'm also taking a bunch of the standard vitamins and minerals. Going to try for topical tretinoin next.
uuu can take estrogen and grow soft boob and butt :3
Zoomers will really do anything except do sports and flirt with chicks, huh?
>>77157904Why take testosterone if you already take nandrolone?
>>77149760So many compounds with unique properties exist...
>>77158001The average age in these threads is 30
>>77149760What are the consequences of microdosing LSD everyday? Is it a working and safe way to boost cognition?
>>77155012They work well in a petri dish and nowhere else. Give me a hammer and I'll cure you every type of cancer in a lab. I'll even publish an AI generated study about it.
>>77157904>1 mg TirzepatideI bet you pay $300 for a 10mg vial because you fell for the microdosing meme.>1 mg PitavastatinGood shit, see if you can tolerate 2mg. I'm slowly working up to it.
>>77158674>see if you can tolerate 2mg. I'm slowly working up to it.NTAWhat do you mean by "tolerate"? Is there some kind of adverse reaction?
>>77158677As with every statin, some risk of myalga and increased liver enzymes. Pitavastatin is just the one statin with the least amount of side effects that also doesn't affect HbA1c.
>>77158678Looks like it's caused by Q10 and vitamin K depletion, and can be avoided by supplementing them. Have you tried it?
>>77158684I take vitamin K2 as part of my multivitamin anyway and CoQ10 caused me severe stomach pain so don't want to use that one.
>>77158672True. I think this anon is making a mistake by trying to use hundreds of different molecules with dubious efficiency. We should focus on finding drugs that do many positive things systemically, like telmisartan, aspirin, pitavastatin, montelukast, dutasteride, methylene blue, coffee etc.
>>77158700>CoQ10 caused me severe stomach painEven when taken with food?
>>77158709Yeah I couldn't stomach it.It's all so random with supplements, some give me severe side effects, others do nothing and some feel like small miracles.
>>77158702What we need right now are effective medications against various cancers, dementia and infectious diseases.
>>77158739>infectious diseases.Just wash your hands and avoid contacts with brownoids.
>>77149760I’ll stick to my injectable pig brain slushy like every sane person, thank you very much
>>77158754The immune system ages and eventually everything around you can and will kill you.
>>77158755>injectable pig brain slushyWhat are the evidence that it actually works? Also there's one redditor that ruined his brain with it https://www.reddit.com/r/Cerebrolysin/comments/13fiark/cerebrolysin_nightmare_an_update/
>>77158758Boo hoo for him I guess?
>>77158785If you're really that fearless and like to experiment - i suggest you to try URB-597 or Redafamdastat and then report back.
>>77158785Or you can try another russian drug called Aviandr, it's a powerful nootropic acting mainly through serotonin antagonism.
>>77158786>>77158793I don't take requests
>>77158674I'm in Canada so I admittedly pay way too much, it's not $300 though. 1 mg is enough to cut down my impulse eating which is the main benefit.
>>77158824But you seem fine with injecting pig's brains.
so where do i buy the brain rejuvenating pills
>>77158927At the pharmacy.
>>77158916But you seem arrogant enough to think I will take your suggestions
>>77158944So you're actually a pussy. Sad...
>>77158950what stops you from doing them then? are you projecting maybe?
>>77158953I never implied i take substances with unknown effectiveness and risk profiles.
>>77158962You never implied you weren't a pussy either
>>77158970Yes, but what you're doing is worse since it's equivalent of being safe-edgy.
>>77158972did I ask? did anyone ask you of your opinion of me? no? okay, keep on keeping on then
>>77158985>did I ask? Yes, you're very interested.
>>77149760Is there a point in using HDAC inhitibors from time to time if i don't have cancer?
>>77159110>That alphabet You're cancer itself
>>77159110Found this study>Valproate reopens critical-period learning of absolute pitchhttps://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2013.00102/full>>77159119You seem upset.
>>77158739>dementiaYokukansan. It's an asian drug that counters cognitive decline by decreasing serotonin receptors.
>>77149760Informative book from Lyle McDonald about bromocriptine (dopamine agonist drug).
>>77155002>YokukansanWhat dosages are you doing for the succinate & R-ALA?
>>77149928This is completely a troll by the way. Its well known that Proviron is extremely prone to cause shedding and fin/dut do nothing to help because its already DHT. Plus it shuts down your natural production so you'll be hypogonadal in weeks.
>>77160164You're talking to >>77149823
>>77160164>Proviron is extremely prone to cause shedding and fin/dut do nothing to help because its already DHT. Retard, see picrel. >Plus it shuts down your natural productionIt doesn't shut down natural production at dosages of 6.25mg unless you have very low SHBG. Source - Vigorous Steve who tested it on his clients, also lab reports on proviron only cycles from 4chan.
>>77149760Here's a somewhat unknown hack - sounds retarded, but it is 100% legitKeep your place VERY clean, literally shining by wiping desks/countertops and sweeping/mopping the floor every day. This may be 30-60 minutes every day. It is worth it for the obvious reasons (cleaner, less bacteria, feel mentally better seeing a cleaner place), but also an important hidden reason - Clean surfaces reflect a LOT more sunlight. I really polished the top railing on my balcony recently and this morning when it was sunny the reflection was literally hurting my fucking eyes. It's a (pardon the pun) night-and-day difference.I spend ~30 minutes everyday polishing the counters and floors and balcony railing of my apartment, and I added a big foil sheet to the ground of the balcony area. The foil is also a game changer (you can buy giant 50-footX4foot foil sheets of Amazon, very durable - not the kitchen stuff), it reflects so much sunlight you can cook yourself if you're standing at the right spot.Clean everything and strategically place foil where the sunlight hits and you can feel like you moved to Miami. It's a great lifehack and I feel like the weather is twice as better as it really is, I get a huge amount of sunlight now and I constantly have energy.
>>77149760>Palonosetron triggers 5-HT3 receptor internalization and causes prolonged inhibition of receptor functionhttps://www.sciencedirect.com/science/article/abs/pii/S0014299909008693The present work shows, through several independent experiments, that palonosetron uniquely triggers 5-HT3 receptor internalization and induces prolonged inhibition of receptor function. After 24 h incubation followed by dissociation conditions, [3H]palonosetron remained associated with whole cells but not to cell-free membranes (P < 0.001). [3H]Palonosetron's binding to cells was resistant to both protease and acid treatments designed to denature cell surface proteins suggesting that the receptor complex was inside the cells rather than at the surface. Cells pretreated with unlabeled palonosetron subsequently exhibited reduced cell surface 5-HT3 receptor binding. Palonosetron-triggered receptor internalization was visualized by confocal fluorescence microscopy using cells transfected with 5-HT3 receptor fused to enhanced cyan fluorescent protein. In contrast, granisetron and ondansetron showed minimal to no effect on receptor internalization or prolonged inhibition of receptor function. These experiments may provide a pharmacological basis for differences noted in published clinical trials comparing palonosetron to other 5-HT3 receptor antagonists.
>>77149760NAC bros... https://www.sciencedirect.com/science/article/abs/pii/089062388890010X>N-acetylcysteine (NAC) is known to enhance the renal excretion of heavy metals. Therefore, we investigated whether the teratogenicity of metals (Hg, Cr, and Cd) can be ameliorated by NAC in mice. Contrary to our expectation, the incidence of congenital malformations produced by these metals was two to three times higher in the mice that were fed NAC (0.2% in the diet). The underlying mechanisms are unknown and should be investigated.
NAC for microplastics and nanoplasticshttps://www.mitochon.it/en/n-acetylcysteine-new-perspectives-against-the-damage-caused-by-micro-and-nano-plastics/?v=0b3b97fa6688
>>77162160Another recent study dropped, showing it can induce an FAS-like phenotype in offspring:>https://stories.tamu.edu/news/2026/02/02/more-isnt-always-better-texas-am-research-links-high-dose-antioxidants-to-offspring-birth-defects/FWIW rats and mice get cancer from it too but humans don't, so unless human case reports of FAS in kids of NAC users, it isn't that alarming.NAC still has a lot of positive research dropping recently such as:>https://bioengineer.org/n-acetylcysteine-protects-rats-from-doxorubicin-heart-damage/>https://www.nature.com/articles/s41598-026-37274-8>https://www.nature.com/articles/s41398-025-03580-4>https://www.nature.com/articles/s41598-025-01557-3>https://www.nature.com/articles/s41598-024-78387-2
>>77162467So, just don't give NAC to lolis you impregnate and it's gonna be fine.
>>77162515The recent study finding a FAS phenotype ack-shilly involved PATERNAL administration, so discontinuing it in both parents a while b4 reproduction is probably the safest, but decent chance it's a nothingburger when something so popular only has these problems detected in special transgenic mice.
>>77154820Just don't eat it upright like a faggot ass orangutan niggerWiz Khalifa said it was suss yoBreak it in halfOtherwise looks like your slobbin on a dildoWhat you gon' shove it up yo ass nigga?Faggot
>>77159281was going 200mg bumped to 600, went back and read brad's stuff and now at 1200mg split across my two main meals. Succinate, I found mag succinate capsules on amazon (they have pure succinate crystals but it's sour as fuck and needs a base like baking soda added and some sweetener) and I'll do about 6000mg of that also split. Thinking about bumping succinate up to 10g/day though which brad outlined for people close to goal weights.
>>77149760>A possible effect of montelukast on neurological aging examined by the use of register datahttps://pmc.ncbi.nlm.nih.gov/articles/PMC8214582/#:~:text=Objective%20To%20investigate%20if%20montelukast,changes%20associated%20with%20human%20aging.Previous use of montelukast correlated with improved scores on cognitive or neurological functioning (F=2.20, p=0.03 in a multivariate test). A range of other medications were tested with the same algorithm, including drugs acting on the immune system, but none of them correlated with (overall) significantly improved test results. Conclusion The present data suggest that montelukast may alleviate degenerative neurological changes associated with human aging.
Senolyticbros...>https://today.uconn.edu/2026/03/popular-anti-aging-compound-causes-collosal-brain-damage/>Popular Anti-Aging Compound Causes Callosal Brain Damage>Part of the brain disappears in mice treated with dasatinib and quercetin>“When you administer this cocktail to an animal, young or old, the myelin is damaged, which makes it disappear. Even worse in the young animals” than in the aged ones, says UConn School of Medicine immunologist Stephen Crocker.FWIW I've had fairly high cumulative doses of a more advanced senolytic cocktail not including dasatinib, but including a lot of experimental remyelination-enhancing agents, and haven't had any M.S.-like symptoms. Myelination support might turn into a standard adjuvant for senolytics.
>>77163072>When the researchers looked closely at the damaged brain tissue, they found clues as to why the myelin had disappeared. The myelinating cells—oligodendrocytes—hadn’t died. They’d regressed into a juvenile form of themselves.How ironic. >including a lot of experimental remyelination-enhancing agentsRemyelination works seemingly different in rodents and humans. I planned on using pranlukast at remyelination agent because it's a highly effective GPR17 antagonist, but in human cells it actually doesn't work. https://pmc.ncbi.nlm.nih.gov/articles/PMC6685917/pdf/nihms-969591.pdf>Because GPR17 agonism prevents differentiation of hiPSCderived oligodendrocytes, GPR17 antagonism should promote their maturation and, consequently, qualify as an effective strategy for remyelination therapy in humans. So far, pharmacological GPR17 inhibition has only been achieved with the cysteinyl-leukotriene 1 (CysLT1) receptor antagonist pranlukast both in heterologous expression systems and primary rodent oligodendrocytes (Hennen et al., 2013; Ou et al., 2016). Surprisingly, pranlukast was incompetent to facilitate human oligodendrocyte differentiation. Rather, akin to the results observed with MDL, it reduced the viable oligodendrocyte population and diminished the number of O4-positive cells (Figure 1K), thereby uncovering an unexpected detrimental effect on cell survival. Note that pranlukast was applied at a concentration sufficient to achieve full GPR17 inhibition, in agreement with previous reports by us and others (Hennen et al., 2013; Ou et al., 2016). As a consequence, none of the above compounds qualified as a pharmacological probe to abrogate GPR17 signaling in human oligodendrocytes and to be evaluated further as a remyelinating agent for potential use in humans.
Anyone know how to get better memory get rid of brain fog
>>77163339Do you have access to prescription drugs?
>>77163370No i just take vitamins
>>77163339Lion’s mane
>>77163405Then take magnesium and 10k vitamin D.
>>77149760>Poorer aging trajectories are associated with elevated serotonin synthesis capacityhttps://www.researchgate.net/publication/372415656_Poorer_aging_trajectories_are_associated_with_elevated_serotonin_synthesis_capacity
>>77149760Hyperbaric oxygen therapy at 2 atmospheric pressures works when combined with 100% O2 or close to it.Problem: The units are like two tons of steel to sustain these pressures. Cost all in for a unit you can sit in is like $30k-$140k all in
>>77164023What are the expected results?
>>77149760What is the optimal bodyfat % for longevity? Is being ultra-lean and muscular optimal?
>>77164779>What is the optimal bodyfat % for longevity? Is being ultra-lean and muscular optimal?Probably around 10-15% for men and 15-20% for women, slightly overweight but lean either way. The literature is a little conflicting.
>>77149760Is lactoferrin a meme or truly a powerful anti-aging compound?
>>77149760Is it a good idea to use antypsychotic drug as a nootropic agent?
>>77165240I found study on primates (that can be considered equivalent to healthy humans) that show it to be effective. >Effects of lurasidone on executive function in common marmosetshttps://www.sciencedirect.com/science/article/abs/pii/S0166432813000934Haloperidol, olanzapine and risperidone decreased correct performance even in the easy trial of the task. All drugs, except lurasidone, impaired success rate in the difficult trial. On the other hand, lurasidone dose-dependently increased marmosets’ success rates in the difficult trial with significant effect at 10 mg/kg. In conclusion, we have shown in this study that lurasidone, unlike conventional antipsychotics, improves cognition associated with executive function in common marmosets. These findings suggest that lurasidone would be more useful for treatment of schizophrenia cognitive impairment than other antipsychotics.
>>77149760Drink beet molasses.
>>77165062>The literature is a little conflicting.Probably skewed by starving negroids.
>>77149760>IgG is an aging factor that drives adipose tissue fibrosis and metabolic declinehttps://www.sciencedirect.com/science/article/pii/S1550413124000159
>>77149760>A metabolic atlas of mouse aginghttps://www.sciencedirect.com/science/article/abs/pii/S1550413125004760>Biomarkers of ageing of humans and non-human primateshttps://www.nature.com/articles/s41580-025-00883-8
>>77163339
>>77167576What molecule is that? AI can't recognize it.
>>77149760This shit isn't rocket science.The brain is made out of saturated animal fat, cholesterol and a bunch of vitamins and minerals that only exist in animal-based foods.You develop and rejuvenate your brain by giving it the nutrition it needs, avoiding poisons (such as sugar, caffeine, alcohol, tobacco), and doing difficult things that require using your brain.Raw eggs, raw meat, raw fish. Writing, reading, developing a skill (music, speaking, social skills, any type of craft, etc.). Avoiding low quality passive content consumption.Cardiovascular exercise, especially high intensity cardio (sprinting) will make a night & day difference.All this talk about this or that drug is just hair-splitting bullshit that won't make a tenth of a difference than doing all the above, and will come with serious negative long term side effects.
>>77168027>The brain is made out of saturated animal fat, cholesterol and a bunch of vitamins and minerals that only exist in animal-based foods.Bro...
>>77149760New epic anti-aging drug found...
>>77158662Doing 10ug doses, I found that second day in a row wasn't as 'bright' or 'cheerful', and the 2 times I tried to do 3 days in a row I felt a bit tired, maybe overstimmed from multiple days in a row? Brain chemistry is delicate, so I stay cautious. I usually aim for a 48hr break between micro doses, psilocybin or lsd, and that's when I was doing it pretty seriously/regular.
>>77168798>I usually aim for a 48hr break between micro dosesSo, what are the benefits?
>>77168040>depending on AI for your opinionsRetard alert.
>>77169716Large proportion of this fat are PUFAs.
>>77168658Biojew-kun, your analysis?
>>77149760Taking salbutamol increases your strength through neuromuscular efficiency forever. >Salbutamol modifies the neuromuscular junction in a mouse model of ColQ myasthenic syndromehttps://pubmed.ncbi.nlm.nih.gov/31220253/
bumping schizo thread
>>77171055Tried bromocriptine today. Surprisingly it improved my vision. Didn't know it was existing effect of this drug.
>>77168658>>77171012Clitostacylol looks fairly based as deranged China PDE inhibitors go, although wikipedia says it'll ACK the roidtroons on here with heart failure. I'm currently on Luteolin, which is a less selective PDE and MMP inhibitor with some fairly similar activity.
>>77167909donepezil
>>77149760Idk if this counts but>grow up normal at first>series of shit experiences make me mildly anxious but nothing major can do stuff still>get in great shape around 18 and become confident even extroverted>really shitty experiences, actually bizarre stuff that if I described most here would think I was larping, leave me an anxious wreck terrified of other people, stop caring about health get out of shape makes me even more anxious>entire year of daily panic attacks>go neet, gets worse>try to exposure way out of it barely have any improvementI had enough after a while. I kept doing research discovered beta blockers. I don’t like the idea of being reliant on a medication. Everyone I spoke to everything I read say beta blockers offer no permanent effects. The jewy pill peddler psychiatrist I spoke to was really condescending towards me (go figure, he makes money on people needing meds indefinitely). My idea was simple.>use beta blockers in a structured protocol/routine combined with exposure to gain permanent effects>in the heat of the moment have the mental clarity from no physical anxiety symptoms messing things up to in real time work through the anxiety and overcome itAnd that’s exactly what I did. I only needed about 10 doses. The protocol was basically go do 4 social things this week, can be anything shop at the mall during peak hours talk to a cute cashier job interview etc so long as it’s something that pushes me out of my comfort zone which has caused anxiety. But you can only take the beta blocker on some of them. So, thing 1&2 use beta blocker to do, thing 3 no beta blocker, thing 4 use beta blocker. And then each week you use less so the next week may be thing 1 do with beta blocker thing 2 without thing 3 with thing 4 without and so on. It can be varied, for example maybe you stay at the twice a week level but you also go do the anxiety inducing things more so it’s 6 social things a week but only two uses of beta blockers a week.
>>77173640The concept is simple it’s just exposure therapy with training wheels. The drug allows you to realize in the heat of the moment “why am I anxious? This is so mundane. I’m not in any danger. In fact I could kill this guy interviewing me lol. There’s no tiger chasing me I shouldn’t feel adrenaline”And that’s kind of the issue. The brain learns the adrenaline response in mundane situations is somehow beneficial to your survival. You may not have been in danger but your body/brain learns “well I had an adrenaline response to this sort of thing a few weeks ago and came out alive so it was clearly needed I better keep doing that” and it compounds and gets worse and worse. You need to short circuit that and have those experiences without adrenaline and practice in the moment introspection explore how you feel about the situation. So your brain can unlearn that.I was right btw, literally smarter than a supposed doctor. Any retard can pass tests and be a doctor though. I got the idea from reading an account of a musician who would use it for stage fright and then after so many years would often forget to take it and be just fine because he had done it so many times he no longer had stage fright. Idk why this would be deemed impossible it seems like a pretty basic concept. You can’t exposure therapy if every time you get adrenaline response, that just strengthens the issue and makes it so you will continue having that problem. But if you can “shut off” adrenaline or at least some of the physical symptoms you can strengthen the opposite to that.
>>77173640>>77173643Very interesting story, anon, thank you for sharing. What beta blocker you used? Probably propranolol? What where the doses? I don't need it myself, just scientific interest. >>77173643>Any retard can pass tests and be a doctor though. True, most of them are scientifically illiterate. >An Abrupt Transformation of Phobic Behavior After a Post-Retrieval Amnesic Agenthttps://pubmed.ncbi.nlm.nih.gov/25980916/
>>77149760I fucking love this thread. Keep it running.
Been thinking about cycling aspirine for some metabolic function improvements while on my cut.How much of an improvement would Aspirin make towards fat oxidation? 10%-20%? Any anecdotals here?
>>77173864I've been using 375-500mg of aspirin for the last 3 months and haven't seen any fat-related effects, in fact i gained to 100kg (picrel) so at least it's not interfering with bulking. Mitochondrial uncoupling effect start to become significant at large doses, like 1-3g a day, according to studies i found. Bromocriptine seems to be safer and far more effective for weight lose while on a cut since it mimics leptin (which drops during caloric restriction) and preserves muscles due to growth hormone upregulation, so i started using it (while keeping aspirin) yesterday along with protein-sparing modified fast.
>>77173640>>77173643Thanks for this anon. So this is why exposure therapy doesn't work for me... What if I set myself up so I dont have an adrenaline response, but it makes me a mute? So basically I build up tolerance without adrenaline but that also means Im fucking weird? Because if I try to talk I get adrenaline, and by your account as long as that response is there I just reinforce the bad pathways no matter how well I perform. So if I become a (partial) mute and get no adrenaline even if the situation is weird, I prove to myself that adrenaline isn't needed and I can be weird and still survive? Then if I get used to that I can start talking again?You seem more smart so I would like your opinion on it, but I will try this out regardless. Basically, rely on acceptance from the outside without asking for it.
>>77173894Anon, I have issues with brain fog and would like to improve my nutrition for improved nerve health and whatnot. I absolutely despise eggs, but still think I need choline. Should I trust my appetite and not eat eggs, or supplement choline?What other basic nutrients for cognition am I missing? I basically have brainfog and back of neck tension all the time, even with good posture. Feels like the area is "nauseous", in my neck, like a vague feeling, goes down to my heart and gut as well. I guess something nervous system related. Am I fucked? Coffee doesn't stimulate me either, even without any tolerance.And to reset the metabolism, is it advisable to gain a little weight? Like animals during summer, signaling abundance and countering cortisol in a primitive way?
>>77149760i found a drug stack which works smilar to dnp to increase metabolism but i ain't gonna tell you fitcels..............
>>77174063>works smilar to dnp to increase metabolismNegroid, there's plenty of mitochondrial uncouplers besides DNP.
>>77174068yeah and they area all garbage, my stack works produces strong theromogenis.............
>>77174071>yeah and they area all garbageYour "stack" is garbage too then... Sad.
>>77168658Cilostazol upregulates cAMP which then activates calpistatin, which inhibits calpain. Calpain degrades protein in muscle tissue.
>>77149760Is boosting growth hormone a good way to increase lifespan? I saw it in Epstein Files (lol) and don't know what to think about it. Anyone researched?
>>77175132>Is boosting growth hormone a good way to increase lifespan?>I saw it in Epstein Files (lol)No. Some of the downstream signaling pathways activated by it are (like PI3K/AKT), but GH itself is too messy and not a good anti-aging treatment. mTORC1 overactivation is the worst problem overall. NAD and metformin were also mentioned in there and are better, but this is all just a tier above that famous schizo meme...>(((adrenochrome)))
I'll literally test CRISPR stuff or PE stuff on myself if you guys fund it and make it for me. I don't give a fuck.T. /fraud/er.
>>77175277Figure out a way to knock down/out ur type IIB activin receptors and see what it does.>t. dismayed by their difficulty in druggability
>>77175292What have your experiences with guanfacine been like
>>77175287There's already human grade CRISPR knockout kits for myostatin. Making them penetrate the cells is the part I wouldn't know how to do, people say fungus but I'm not a bio-engineer. I'd be willing to test it on myself if someone made it though and crowdsourced the 1200 or so dollars to buy the human grade kit. Basically I'm saying I'd guinea pig myself out if anyone wanted to make it and test it on a human before themselves.
>>77155002Update: Finally hit goal weight on this, though I should probably lose about 4 more lbs. I'm reliably getting body temp spikes up to 99.6-100.1f after meals now so I'll up to maintenance and see if the thermobolic affect can do the rest. Reading through other people's experiences, weight gets noisy at this point in the diet but the waist does seem to keep going down measuring week by week and checking the mirror.
>>77175302>human grade CRISPR knockout kits for myostatin.See, the nice thing about waging genetic jihad against type IIB activin instead of myostatin is it's not gonna blow your hamstring tendons out like Clav's bussy in an Osceola county ad seg block after a late commissary delivery.
>>77175335Why not both? I thought activin was for fast twitch muscle strength, and myostatin inhibition was for super muscle growth. There's also an 8 times bone density gene I'm interested in.
>>77175341I'm doing a few myostatin inhibitors, but not overly potent ones for a good reason...>Growth Factors. 2009 Aug;27(4):247-54. doi: 10.1080/08977190903052539.>Myostatin in tendon maintenance and repair>https://pubmed.ncbi.nlm.nih.gov/19591015/>Int. J. Mol. Sci. 2023, 24(7), 6634; https://doi.org/10.3390/ijms24076634>Effects of Myostatin on Nuclear Morphology at the Myotendinous Junction>https://www.mdpi.com/1422-0067/24/7/6634The few natty myostatin knock-out/down mutants who have posted on here generally reported various degrees of joint/tendon problems.
Durateston 250mgMK-677 12,5mg 25mgProviron 50mgÔmega 3 600MGNAC 1.200mgAlpha GPC 600mgZinco quelado 29mgGlucoVantage 100mgGlicina 5gTadalafila 5mgWhat should I add or change?
>>77175302>There's already human grade CRISPR knockout kits for myostatin. We need this for FAAH enzyme.
>>77175335From wikipedia - "activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function." Why would you want to knockout it? Looks like it will result in low FSH.
>>77175576Give me a redpill on that one
>>77175589FAAH is the enzyme that breaks down anandamide. Anandamide is an endocannabinoid that inhibits all kinds of pain - mental and physical, it also enhances regeneration and reduces inflammation. Here's a story about human born without gene coding for FAAH - https://www.theguardian.com/science/2019/mar/28/scientists-find-genetic-mutation-that-makes-woman-feel-no-painIn 2016 there was a FAAH-inhibiting drug in development, but some participants died because they used megadoses and experiences off-target effects. Since that time many new substances with strong FAAH-inhibiting has been found, but not one has been developed as a drug due to this incident.
>>77175594Lack of pain seems like a terrible idea honestly. If you break something or your hand is on something hot, how do you know to stop before further damaging something?Also does it make you not feel at all? Because I'd like to feel sex.
>>77175595>Also does it make you not feel at all?No, just negative emotions.
>>77175597Oh, so you can still tell if your bones are broken then to further prevent from injuring them?
>>77175605You can obviously feel if you had serious injury. However, you may not notice some subtle injuries like small tendon pull or chronic inflammation in some part of your body, and will need to do medical analyses from time to time.
>>77175594>inhibiting pain instead of learning how to use itnever gonna make it
>>77175617>vidrelHoly slave morality...
>>77175611I'll add it to my future gene transplants I want.>ACTN3 knockout kit for muscle strength and speed>Myostatin knockout kit for mass muscle growth and huge fat nuts>lrp5 for 8 times bone density>FAAH for anti-pain and mental health>Mkx gene therapy for increased tendonsModifications I want>tooth regrowth drug after getting the irp5 8 times bone density, so my new teeth are unbreakable>stem cell injections into knees and other cartilage weak areas for regrowth>reverse aging drugs used on mice>stem cell injection into platelets for bone lengthening, in multiple areas for a bigger and perfect frame>HGH to go with it so my non-bone stuff grows into the new frame>anti-lox topical cream + vacuum device for penis enlargement>leydig cells from my skin into my nuts for bigger nuts and natural testosterone boost>HCG to boost testicle growth, testosterone, and sperm count when I'm not using the anti-lox (it actually stunts the anti-lox growth)>stem cells into the penis + ultrasounding to heal and grow the veins for better bloodflow>same but in other areas where I want increased bloodflow for lifting>stem cell injections to the scalp and light treatment for hairloss and hair density (I have all my hair but for the future)>laser eye brightening>light based permanent hair color changing to stop my hair from greying in the future (wait this one might be available now, I just looked it up, Loreal color sonic)All of these but the FAAH have been tested on mice before. I don't know about the FAAH one since I just heard about it from you.
>>77175366Have you researched MSM? I found some articles on ergolog with data about it boosting GH and IGF sensitivity, which will lead to better tendons and joints. It seems to be popular among bodybuilders. >MSM, growth hormone and IGF-1 | Stronger bones, stronger muscles?https://ergo-log.com/msm-growth-hormone-igf-1-stronger-bones-stronger-muscles.html
>>77175620The pain you can inflict on yourself is far greater than anyone else can inflict on you.If you are not able to inflict so much pain on yourself that you have to look for more and more extreme ways to do it, you will always be a slave to an outside world that can inflict more pain on you than that. This is why torture is not an efficient means of extracting information. Whatever you extract from weaklings, will never be things that are important enough to matter. If you don't understand this, you are the slave.
>>77175833Negroid, shaolin monks are literally the slaves of the CCP now. Before they were conquered and domesticated by commies to the present state in which they can only preach non-violence they were cult of killers actively engaging in lethal warfare. Stop rumbling this new-age post-christian nonsense.
>>77175859post body
>>77176043
>>77176055unfortunate
>>77176093Are you 170cm?
>>77176097185
>>77175647>ACTN3 knockout kit for muscle strength and speedLel nope u gots that backward, u want to *OVER-EXPRESS* the R type of ACTN3 protein for that. Knocking it out will give u skelly ultra-marathoner phenotype.>>77175809MSM looks pretty legit for joint health, especially combined with glucosamine and chondroitin.
>>77149760Found those eyedrops just now. Composition (5 mL):Pilocarpine hydrochloride — 50 mgBoric acid — 95 mgWater for injections — up to 5 mLPilocarpine is a potent nootropic acting as agonist of muscarinic receptors. Boric acid is a supplement for joint and connective tissue health, also lowers SHBG, thus raising free testosterone. Is there a reason not to drink it everyday?
Op come back I want super human powers
Can anyone share info on spine health? I'm mostly interested in disc health, bulges/herniations, etc. Interesting thing about the discs is that like 50% of people with bulges/herniations don't experience any symptoms. I have bulging discs at L4+L5 and I get some mild sciatica that is tolerable but makes me conscious of certain movements like bending and twisting.One thing I've learned is that discs are fully hydrated upon waking up in the morning due to water absorption overnight and lack of compression. This is why you are taller in the morning, bulges are more pronounced, space between vertebrae are larger. After a few hours of standing and walking, this fluid "seeps" out into nearby tissue, gradually losing water over the day. The process repeats with the discs rehydrating at night and this is how nutrients are cycled through the discs. Dehydration might result in slower healing if there is damage.Because the discs are larger and more hydrated in the morning, this is also when people are hypothetically more prone to injury. Compression on a more hydrated disc results in more pressure which can lead to small tears in the tough outer ring of the disc, the annulus fibrosus. These tears are normal and somewhat inevitable with age but can lead to larger bulges or herniations if they don't have time to "heal". Of course this can happen at any time of day with enough pressure/torque.I'm not sure if discs "heal" in the sense that they can revert to original state, but it seems as if they might "stiffen" or "toughen" in response to injury. This is why older people are stiffer and less flexible.
>>77176598Researched more. Pilocarpine has poor BBB permeability and actually acts as muscarinic antagonist at pancreas cells that leads to reduces insulin secretion.
>>77150007>>77150010I like how this retard which spams with pseudoscientific nonsense in other threads now got silenced in this thread while presented with this simple example.
>>77176127Have you looked into boosting StAR enzyme? Seems like a good enhancement target.
>>77175287>dismayed by their difficulty in druggabilityBimagrumab exists.
>>77149760>High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signalinghttps://pubmed.ncbi.nlm.nih.gov/38766160/
>>77149760>Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signalinghttps://www.sciencedirect.com/science/article/pii/S1550413122001826Another reason why protein-sparing modified fast is the best diet for fat loss.
>>77178368>Bimagrumab exists.>-umab>(((2026)))Picrel, that's not exactly the easiest druggability in the world compared to say, GSK3-β or PI3K/Akt.
>>77175647>my future gene transplants>lrp5 for 8 times bone densityTurns out Baicalin inhibits Sclerostin and L-threonate inhibits DKK-1; those look like two different easily combined mechanisms for jacking up LRP5 activity without any DNA alterations.>https://insight.jci.org/articles/view/98673>https://www.tandfonline.com/doi/abs/10.1080/07391102.2019.1599427>https://pubmed.ncbi.nlm.nih.gov/21034532/
>>77178382So you're saying I should do Gomad and high doses of vitamin D and the excess calories will turn to muscle?
>>77149793Appointed Cardinal for how Holy & Based this was
>>77177891GroundingCopper spiral ring
>>77178638Good info.
>>77163072>Myelination support might turn into a standard adjuvant for senolytics.Microdose fluoxetine for allopregnanolone-induced remyelination. >SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptakehttps://pmc.ncbi.nlm.nih.gov/articles/PMC2670606/
>>77153409That icariin study is interesting but icariin is a glycoside, poorly bioavailable, most of it passes through unabsorbed. The real compound is icaritin (the aglycone). L. plantarum β-glucosidase cleaves the sugar moieties off icariin into icariside II into icaritin. This is one of the most published enzymatic biotransformations in the fermentation literature. Icaritin is dramatically more potent at PDE5 inhibition, has steroidogenic activity icariin doesn't, and the mitochondrial clearance effects from your study would likely be stronger with the aglycone form. Fermenting horny goat weed with L. plantarum for 2-3 weeks produces what the study should have used.
>>77178638Based
>>77179617Everyone is talking about this nigga right now. We're finally getting their face reveal after like 10 years.
>>77149760>Drug that blocks estrogen repairs Inguinal hernia without surgeryhttps://news.feinberg.northwestern.edu/2025/02/05/drug-reverses-groin-hernias-in-male-mice-without-surgery-shows-promise-in-humans/#:~:text=Using a novel%2C medication-based,to repair the hernias medically.”In the mouse experiment, the scientists injected the anti-estrogen drug, which is currently approved to treat some types of breast cancer, into a humanized mouse model designed to mimic the higher estrogen levels found in aging men. When scientists blocked ESR1 in these connective tissue cells, it prevented muscle damage and hernia formation. Using fulvestrant in the study inhibited the ESR1 in the mice, which helped shrink large hernias and restore the mice back to their healthy anatomy.In the human arm of the study, the scientists biopsied each participant twice — one from the hernia site and another from an adjacent healthy muscle — and found the same biological markers as in the mouse model. Further analysis showed that estrogen and ESR1 activate a set of genes linked to excessive tissue scarring, matching patterns seen in hernia tissue from human patients.
>>77153099fly agaric? that didnt make me trip at all, it just completely blunted my anxiety which kind of made me feel like an angry sociopath
When they study mice they give them a disease and then block it on the same pathway that causes the disease, and sometimes obfuscate it the same as true healing; its prevention of a disease they invented in the mouse. And they point to some gene pathway as the top regulator because they can test for it…but it could be more complicated. So this is what to be aware of when you see a lot of overhyped studies. Mice don’t live long and get cancer. I don’t have time to analyze the sheer number of these studies. Also typical is the review of biological compounds / nutraceuticals and disease treatment. If it actually worked it would cure people. They usually conclude “more study is necessary” Theres hundreds or thousands of papers with chinese/indian names like this. They are about as reliable as AI hallucinations.
>>77181347> When they study mice they give them a disease and then block it on the same pathway that causes the disease, and sometimes obfuscate it the same as true healingIt is true healing.
>>77149760Alkaline environments hyper-accelerate the Maillard reactions>Formation mechanism of AGEs in Maillard reaction model systems containing ascorbic acidhttps://www.sciencedirect.com/science/article/abs/pii/S0308814622000693
>>77181556why /ck/ didnt inform me of this?brb going to get sodium bicarbonate
>>77149760Boswellia and nigella sativa block the same brain inflammation pathway that the asthma drug targets, but earlier in the chain, they stop leukotrienes from being made instead of just blocking the receptor.
>>77181900Natural solutions are almost always inferior to synthetic drugs or isolated molecules, because you can't know if it has the same efficiency as drugs (often times less) and can control the dose. They should be used only if their effects are unique and acting compounds hasn't been identified yet or they are hard to purify.
>>77181907fair point but, synthesis inhibition IS more comprehensive than receptor antagonism. That's why 5-LOX inhibitors like zileuton exist as pharmaceuticals alongside receptor antagonists like montelukast. synthetic drugs are also a portion marketing.
>>77181907There are counter-examples, though. Like two of the three most potent 5-ARIs identified so far are natural polyphenols.
>>77182137Yet nothing beats dutasteride.
>>77182179>Yet nothing beats dutasteride.Maybe in potency, but only a fraction of the polyphenols make it in2 ur bloodstream compared 2 dut, making them a lot more attractive from the non-trooning perspective.
>>77182193>non-trooning perspective.What specific effects of dutasteride scare you? Because it's a completely safe drug with beneficial off-target effects.
>>77182193There's no trooning or anything i took it for 12 years straight, libido as high as before if not more. may be imagining i dont know, but as a bonus i weirdly kind of stopped aging, i look ridiculously younger than my age for whatever reason, but i take other stuff too so hard to pin point. my only regret is not using it earlier.
>>77178382I'd like more info on this one. Are you saying I can abuse vitamin d to turn my calories to muscle instead of fat?
>>77173640>>77173643I did propranolol for the first time today. 40mg. I can attest that it works. Good job anon.
>>77182730>I can abuse vitamin d to turn my calories to muscle instead of fat?Yes, I take 10k vitamin D a day. Vigorous Steve takes 14k.
>>77182730>>77182860Important note: It must be D3 and not D2, and you should supplement magnesium and boron with it.
>>77182860At Publix they got their Nature Made brand vitamins on half price. Is 10,000 iu good?>>77182889Good advice. I'll get some of that too.
>>77182906>Is 10,000 iu good?Yes. I got 720 tablets of 5,000IU vit D for 6$ because i monitored marketplaces at night when prices usually drop because sales drop.
>>77149760Diflunisal, a salicylic acid derivative, increases NAD+ levels by ACMSD inhibition.>Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan Kynurenine Pathway https://pmc.ncbi.nlm.nih.gov/articles/PMC7856275/In the kynurenine pathway for tryptophan degradation, an unstable metabolic intermediate, α-amino-β-carboxymuconate-ε-semialdehyde (ACMS), can nonenzymatically cyclize to form quinolinic acid, the precursor for de novo biosynthesis of NAD+. In a competing reaction, ACMS is decarboxylated by ACMS decarboxylase (ACMSD) for further metabolism and energy production. Therefore, the inhibition of ACMSD increases NAD+ levels. In this study, an FDA-approved drug, diflunisal, was found to competitively inhibit ACMSD. The complex structure of ACMSD with diflunisal revealed a previously unknown ligand-binding mode and was consistent with results of inhibition assays, as well as a structure-activity relationship (SAR) study. Moreover, two synthesized diflunisal derivatives showed IC50 values one order of magnitude better than diflunisal at 1.32 ± 0.07 μM (22) and 3.10 ± 0.11 μM (20), respectively. The results suggest that diflunisal derivatives have the potential to modulate NAD+ levels. The ligand-binding mode revealed here provides a new direction for developing inhibitors of ACMSD.
>>77183123I got that at Publix yesterday 10k of nature's truth on half price. Publix runs bogo deals. Check your area.
>>77168027Based primal chad.Literally just eat a raw egg in a morning and some putrid month+ old high meat when you have depressionIts so easy to joymax I cant even lol
