>started taking 1mg per week in November 2025>began feeling starving again after a month>increased dose to 1.5mg/wk for another month>starving again>upped dose to 2mg/wk for another month>woke up monday with my stomach tying itself in knots, so hungry that it was physically hurtingI upped my dose to 2.5mg and I guess this is gonna be my weekly dose now but this shit costs me $110 per 10mg and if I have to keep increasing the dose it will be too expensive for me to take. If I stop then I will be starving 24/7 non-stop and will probably balloon into a fatass from my sedentary lifestyle.I'm 175cm 73kg and 15% bodyfat but I sit down all day for work in 12 hour shifts and I need to work 60+ hours per week to pay my rent and expenses. I train every day for 30-45mins mostly weights and some cardio but I've got a bunch of injuries which make doing 10km runs impossible and I don't have time to walk for 2hrs.Has anyone experienced this? Can I reset my body to get good effect from 1mg again?
>>77208965Starting dose in clinical trials is 2mg, target dose is 4/6mg. Half life is 6 days, takes about a month to reach optimal dose in body. You've been scammed, average price is 90-100$ for 100mg.
>>77208965Sounds like you need to change industries and get a better job
>>77208965Your receptors sensitize to it, that happens. I’m in contest prep and taking 10mg tirzepatide/3mg Retatrutide/2.5mg cagrilintide and I’m still fucking hungry. Also you’re paying brutally Jewish prices for your peptides brother.
>>77208965Just stop eating carbs, bro. No need for drugs. Eat unlimited bacon.
Nobody actually reads into the scientific literature on these GLP-1 peptides. They get their info from some tik tok dipshit or a faceberg glp-1 mom group who don't know shit about fuck.You should avoid retatrutide if you're lean and insulin sensitive.chronic GIP agonism from retatrutide without beta arrestin recruitment will perma fuck your hypothalamus' POMC neurons and ruin your leptin sensitivity.Obese fatties already have chronically elevated GIP and leptin insensitivity.Like how fat kids and adolescents can never truely get and stay lean in adulthood, their body fat set point is adjusted permanently higher.tirzepatide is much safer since it has highly biased g protein recruitment at the GLP-1r and hgiher beta arrestin recruitment at GIPr whilst having much lower affinity for the GIPr relative to reta.Of course the safest by far would be maridebart carfraglutide
>>77208965Find a better vendor, you are getting scammed 10X wholesale markup. A kit that should last you a year at 8mg a weekbshould run under $300. If you primarily need appetite suppression get tirz which is even cheaper, $200 for 2 years worth. Check Glp1forum
maybe you shouldnt take experimental research substances
>>77208990cico worked for me. keto has similar dumbass pictures. the non troll answer is pick whatever works for you
>>77209100CICO caused the obesity epidemic. Before anyone heard of the calorie measurement they had no problems staying lean.
>>77208965Why the fuck would you inject unknown chinese bathtub chemicals that don't work and aren't even reta when you could just eat high-satiety foods like cheeses and saturated fats with high protein?
>>77208998anon your very knowledgable, so between sematutide, tirzapetide and retatutide, which one is least likely to fuck up a healthy person? And for an obese person, which one is best?
>>77209144In the past people didn't care as much about eating less, if they got fat they changed eating habits not quantity.If you are fat without eating any junkfood/fastfood, then something is seriously wrong with your lifestyle or diet.
>>77208965Of a second I though this said "retarditide"
>>77209322Yeah people in the past intuitively knew that some foods are fattening (starch, sugar) and other foods are not fattening (butter).Sugar Information Inc bamboozled everyone with flat calorie theory.
>>77209144I just said it worked for me that's not really a retort to my point is it?
>>77208998>chronic GIP agonism from retatrutide without beta arrestin recruitment will perma fuck your hypothalamus' POMC neurons and ruin your leptin sensitivity.Does this applies to DPP-4 inhibitors?
>>77208965so you did no research at all on how to dose this drug before you started taking it, did you?
>>77208990Wild, because I ate 4000 calories a day on keto and got insanely fat, but restricting my calories to 2400/day with carbs included I got insanely shredded.Almost as if....the calories in...must be less than the calories out....to lose weight
>>77209318Semaglutide obviously wins out of the three since it lacks GIPr interaction completely. It could be better though since it's GLP-1r efficacy is actually lower than native GLP-1, but GLP-1 receptors recycle rapidly and you aren't doing any real harm taking it. The constant GLP-1 agonism appears to be a good thing.Tirzepatide does have GIPr interaction, but it's affinity for GIP is way lower, has a lower Emax, much higher EC50, recruits less cAMP and more beta arrestin.GLP-1r activation is protective and tirzepatide is also extremely g protein biased at the GLP-1r, reta is not.For a healthy person, sema > tirz >>>> retaFor an obese person, their GIP is already chronically elevated, leptin sensitivity already fucked, POMC and AgRP/NPY fucked. Honestly reta probably wins here simply because it makes them drop the most weight overall, no other real reason>>77209709I doubt it.But thats a good question, I haven't done very much research into DPP4 inhibitors compared to GLP-1 peptides.My reasoning is: DPP4 inhibitors stop the breakdown of native incretins. Those incretins are pulsatile, only after a meal, and have less CNS penetration than GLP-1 based peptides. So you aren't getting constant GIPr activation 24/7 at supraphysiological levels, only physiologically stronger pulsatile release after meal time.
>>77208965Are you people really taking drugs called Redarditall? Really?
>>77209971Appreciate it amigo
>>77208998>>77209971Fuck me, I bought reta and didn't know thatI'm 18% bf, planned to start at 0.5mg/wk and up to 1mg/wk (max) over a month, and stay on it until cut to 10-12% is finishedIs 1mg enough to fuck my shit up? I'm considering just throwing it away
>>77210018Well strangely enough the low and very low doses might actually be more dangerous than higher doses.Reta is so strong at the GIPr, that by the time you've reached its EC50 concentration at the GLP-1r, you're already activating GIPr at >100% efficacy.Additionally, the limited beta arrestin recruitment that does happen at GIPr doesn't happen until you hit higher concentrations.(the GLP-1 agonism and GIPr beta arrestin recruitment are the protective mechanisms here)Because of it's long ass half life, you're gonna be in this GIP activated without any protective mechanism zone for like 5 half lives after you cease taking it.So if you do decide to take it, the amount of time you take it for matters much more than what dose you take, and don't fucking overeat especially in the 5 weeks after stopping it, or you're speedrunning perma fucked brain damaged obesity.
>>77208974>>77208977>>77209043I know the starting dose is 4/6mg but that's way too fucking much bro. Also I live in Australia so finding a source is difficult unless you can suggest somewhere.>>77209971>>77210054Semaglutide is prescription in Australia and literally hundreds of dollars more though a GP and no GP is gonna prescribe a thin person semaglutide. Reta isn't approved for human use yet so it's free to buy from peptide sites and isn't going against current regulations.
QUESTION TO PEOPLE ON RETA: Do you have problems with food sitting in your stomach for a long period of time undigested?
>>77210054Thank you for sharing all this, I'll just throw it awayI just wanted an easy cut on chicken and potatoes, but I'd rather have a difficult cut than risk being an uncontrollable eating machine later on
>>77208977Doesn't help by saying how to get it at reasonable cost. Fucking roid tranny faggot.
fucking newfag retards stay the fuck away from my peps
>>77210079If you’re having that issue on repa, a common solution is to drink 1/4 a shot of bleach before every meal. It will help the food melt down in your stomach, to be easier for your colon to process. People will tell you not to drink bleach but they’re always failures with weak bodies.
>>77208998>>77209971Could you please post some sources on this?I don't mean this in a "I don't believe you" way, I actually understand all of what you wrote and I'm just interested in reading up more on this. I did some research and wrote a bit of a review on the use of GLP-1r agonists vs SGLT2i for cardiovasculart risk mitigation a couple of years ago in college but I haven't kept up with the literature since then. One of the sources I used was the article you posted the image from, actually, so it'd be interesting to complement this with new information and take retatrutide into account.
>>77210070>>77210091>>77210098grey market, low dose semaglutide is so cheap its basically almost free.No concerns with the GIP agonism thing either
>>77210131>grey marketDude you're talking to someone who has no idea what this is or how you access it.
>>77210128Sure, I'll post some of the sources I can remember reading off the top of my head.Heres a couple that describe how GIP induces hypothalamic inflammationhttps://link.springer.com/article/10.1007/s40618-025-02719-whttps://academic.oup.com/endo/article/161/9/bqaa102/5865317The most worrying sign I think is the increase of SOCS3, which directly blunts leptin sensitivity. I don't have a source that I can remember that says SOCS3 blunts leptin sensitivity thoughI've read a lot of papers on the differences between GIP agonism & antagonism, and tried to apply the findings to lean and insulin sensitive individuals. These were great papershttps://www.nature.com/articles/s42255-025-01294-xhttps://www.sciencedirect.com/science/article/pii/S2212877820302131https://journals.physiology.org/doi/full/10.1152/ajpendo.00460.2007There was another really good one discussing how chronic pharmacological GIP agonism could lead to functional antagonism, I'm trying to find it, but they concluded it was possible but probably not the best explanation as to why agonism/antagonism both produce weight lossThis is a great comparison of the signalling bias of different ligands and receptorshttps://cf-ecom.eurofinsdiscoveryservices.com/wp-content/uploads/2024/02/Eurofins-Discover_ObesityLITE_SLAS-2024-1.pdfThe studies on GIP knockout mice are an interesting read too, not sure if this is the paper Im thinking about, but it does a good job at comparinghttps://journals.physiology.org/doi/full/10.1152/ajpendo.00646.2020
>>77210167Many thanks anon, looks like these will be some comfy reads.
>>77210218Are SGLT2i's good for your heart by the way?I take 12.5mg empag/ day prophylactically for kidney health
>>77210227Possibly, but most evidence of benefits is in patients with pre-existing cardiovascular disease. Some studied mechanisms could also apply to healthy individuals.They have a mild diuretic effect but seem to mostly reduce intersticial fluid instead of intravascular fluid like other diuretics, and this limits the magnitude of the neurohumoral stimulation associated with volume contraction. They also slightly shift myocardial metabolism towards ketones, so the heart is less likely to be in an energy-starved state as it has more options to rely on for energy.Finally, they seem to have an anti-inflammatory effect that acts directly on and attenuates extracellular matrix remodelling and fibrosis.Animal studies have also shown reductions in sympathetic tone, protection against reperfusion injury, and increased EPO secretion, but none of that's been studied in humans as far as I know.In short, they might provide some protection against myocardial remodelling and heart failure.
>>77210248I see, that seems pretty positive and promising. thanks for sharing
>>772100704 or 6 is not the starting dose, that would probably cause your resting heart rate to explode. But 8mg is a moderate dose to.work up to over a few months. Australia is tricky so I'm going to help you out. Can't post source because jans will delete thread and also never accept any direct source links anyway, its usually a scam>Stairwaytogray DOTcom >scroll down join telegram >vendor promos>search term Australia >vendor that ships to Australia and offers reship insurance for 20% fee, starts with a J>They have Sema and triz>1 kit of 20mg tirz, so 200mg total which should last you at least 6 months, but realisticly 9, should run around $80 plus insurance plus shipping =$150ish usd>only use the contact email listed in the vendor promo, anyone else that contacts you is a scam>>77210079Slowed gastric emptying is one of the mechanisms of action for glp1s, so that's normal. If you.overeat it can be very uncomfortable. If you're constantly vomiting then gastroparesis is possible, stop taking and maybe go to urgent care or the ER
>>77208965Exchange current routine with hundreds of reps of bodyweight exercises every day (well, work up to this, you'll be sore permanently). 100-250 reps per set is a good, if rough, goal. I'll wanr you though, you will lsoe all explosive strength, you won't be able to sprint or jump to any meaningful degree. But boy, you will burn through fat like a crazy ass motherfucker as soon as you hit a certain threshold after a few mweeks or months of this. Ottermode Olympus, basically.Usually, I advise against this because it's really bad for performance outside of high reps (or maximal strength, funnily) because it really kills all speed for some reason. But if you just want to stay fit and lean and you wanna eat whatever you want, and nothing else, I guess it's perfect.Just do a max set of push ups and sit ups and squats every day upon waking up. do the main wokout in the afternoo0n or evening, also every day, 3 sets each of the usual calisthenics for high reps. just get the reps in, dgaf about rom. 30-60 sec between sets.
>>77208965>175cm>73kg>15% bodyfat>2026>doin' GLP-1 hammy pepesNiqqa wut u supposed to be bulkin'. I frame-mog yo ass by like 10cm and 20kg with lower bodyfat, don't even shoot up these weird scam vials and be on small molecule glucose disposal agents n shit instead.
>>77210404>small molecule glucose disposal agents n shit instead.>eat glucose>take drugs to get rid of it instead of using it in physical/mental tasks or not consuming it in the first placeMental retardation.
>>77210393Bro one look at reddit and there are dozens of threads from Australians all saying how their overseas shipments of peptides have been seized by customs. I live on an Island it's not like someone can drive over the border with 1 million vials and start distributing. Also, I wasted a bunch of time downloading telegram and I'll have to find a way to linking a fake phone number to the telegram account, and then try to figure out how to buy cryptocurrency, all to order some shit online which could easily just be seized by border force and I'll never have any way of knowing
>>77208965>Has anyone experienced this?being an american? No, you wouldnt know how it feels, simply cannot imagine
>>77209336… which it is
>>77210131>Just go in the Grey market broYou sound like a fucking retard and once again gabe zero info fucking roid tranny faggot
>>77208965Spam thread. You cant be paying this much. I source at less than $0.50/mg. At 60 weeks i am at 5mg/week. 5' 11" 198. Reta is cheaper than the crap food I no longer care to eat.
>>77208998Fuck this nigger. If you are 50+ lbs overweight, you are open to metabolic cancer, arthritis, liver disease, heart disease, brain damage from high blood pressure. Just having the weight off is a game changer. Retatrutide arrested my arthritis in 24 hours and gave me a working foot. From there my training increased. In 48 weeks I lost 50lbs and adopted a healthy life, ate better, stopped using alcohol, in gym 5x week. I skip,dip,squat and I look fit. I dont care about miniscule and unproven outcomes of the far future, when I have made lasting changes to stop known and proven health risks today. Demotivation posters eat shit. I dined with a beautiful woman outside in perfect weather, and looked good doing it. I feel awesome. Not going to worry about a future I would never have lived long enough to see. Got sit in corner if you dont like it you fat blob eyesore
>>77209204Post body. You wont.
>>77209727The phase two trial had some participants at 4mg starting. Other research started at 2mg. I started at 1mg. 1mg per week helps you recalibrate your habits and avoid side effects from too much too soon. 1mg reta a week for a beginner. No need to rush. Enjoy the ride.
