im thinking about starting pio, but i cant find much about itim two years hrt, been on and off prog for the past 6 months, 5'10'', 66kg/146lbs.i know the whole point is to gain weight while on it, so should i lose weight before starting? if so, what weight should i aim to be beforehand, and how much should i gain?i also remember reading somewhere that there is a less risky alternative with the same effects, is this true? is there anything else i should consider taking alongside it, or just in general?where can i source it in the uk? anything else i should know?thanks :3
>>40965905pio is fucking amazing if you do literally anything other than keep exactly the same weight. if you gain weight on it, you grow fat deposits. if you lose weight on it, you lose fat in places you dont want it and what you dont burn gets redistributed to areas you do want it. ive heard it works particularly well with retatrutide.>i also remember reading somewhere that there is a less risky alternative with the same effects, is this true? not really. there are similar drugs but none are as potent as pioglitazone. its the reference drug in all studies on fat cell growth and almost nothing else comes close. however...good things that have helpful effects that go even harder when combined with it include fish oil (adipogenic effects), arginine (mobilises fat deposits through GH related effects), retatrutide (dont combine with arginine), prog (boosts feminine fat deposit lipid uptake) (topical or injection preferred).do not eat a high sugar diet with this, stomach fat is more sensitive to insulin than other fat sites and youll ruin your results from it. go for high meat and fat content, thats your best bet to maximising results.
>>40966434I've been on pio for a month and didnt know about the high sugar diet thing, thanks for thisOverall seeing pretty good results so far
>>40966757yw fren. abdominal fat responds in an exaggerated manner to high sugar, esp high sugar and fat, so ye.
>>40966434this is rly helpful ty!!!
>>40965905it doesnt do anything
>>40966434any recommendations on how fast you should gain weight?i weigh 70kg rn (5'11) and im dropping to 60kg until december, then I want to get on pio and gain 10kg again. Is 3.3kg/mo too fast, even if my surplus is *not* a result of a high sugar diet?
>>40969380slowly. treat it like any tissue gain phase where your goal is to support gradual gain of healthy mass. shoot for 1-2kg a month instead. are you exercising during this?also, why not do pio for the down cycle? even a low dose of it will dramatically improve the efficacy of your weight loss phase in terms of male fat lost and female fat gained.
what are the risks when it comes to pio? im thinking about starting but im an ocdfag and i need to know its like safe or whatever.....pic related
Pio is a meme. Back in the day it was domperidone. Except it's more dangerous.
>>40971816the following is a paper written on the risks of pioglitazone. keep in mind it is entirely related to the treatment of diabetics, who generally have dogshit health and are prone to all kinds of health complications as is. the long term risks from pio are likely related to it just stealing stem cells from non-adipose tissue over time, so if you cycle it on and off (diabetics obviously cant do this) its probably not an issue.https://sci-hub.ru/https://www.tandfonline.com/doi/full/10.1517/14740331003623218
>>4097183110mg EV per week ass post
>>40973472Isn't 10mg a high dose already? I do more than that but aren't hondoses 2mg pills
>>40973486god youre fucking stupid
>>40973502Bruh I have been doing injections for years do you think I remember EV doses after almost a decade of HRT
