How severe are HRT mood-swings meant to be? In the day or two leading up to my shot I often feel crushingly suicidal, but a day or so after I feel amazing and happy. Is this normal, or am I just mentally ill on top of HRT throwing me for a loop every 10 days? It’s been getting progressively worse for the last 4 years, and I’m finally at a point where I’ve changed my routine around enough with no change to my swings to think that maybe it’s another issue altogether.