What do you think of Dr Power’s hypothesis that HSTS individuals have worst outcomes from HRT compared to AGPs?
that doesn't really make sense because lots of the gymbros who troon are hstsblanchardism just isn't a coherent system
>>41449870That’s not the point. If a gymbro is fembrained (read: HSTS), then they will have a worse transition than a gymbro who is malebrained (read: AGP)
>>41449892there's no actual evidence of this
>>41449859for all the criticisms there are over blanchard, and there are a lot of legitimate criticisms, there are ever fewer reasons to take this powers guy seriously tbqh
>>41449859that a general practitioner working at a gender clinic has no place commentingthese are not the takes of an academic
>>41449859Shut up and dispense my hormones, william
>>41449892HSTS are more feminine since birth and have better transitions than AGPs.
I have no idea what he's trying to say
>>41450871powers says otherwise and he's always rightcope
>>41450107>doctor providing bleeding-edge regimens with proven results in the field and care vs... a chaser writing theoretical psychiatric """scientific""" paperscope
>>41450892https://www.reddit.com/r/DrWillPowers/comments/1lk65k0/comment/mzruhxs
>>41450883Our fav doctor is using the fact that estradiol masculinizes the brain perinatally and some very questionable assumptions for some stupid honscience. Yes, I also lost respect for him now.
>>41450871stats? evidence?
>>41450906did you even read what you just posted?
>>41450919>>Unfortunately, for these transgender women who are attracted to women, but feel like a female, typically the cause of this phenotype of normal testosterone and low estrogen signaling is caused by a defect in the estrogen signaling system. Occasionally it is caused by aromatase defects, but usually it is a problem with the estrogen receptor or some other cofactor. As a result, they have a harder time with transition because even when given perfect levels of hormones, the body lacks significant estrogen receptor signaling.Gynephilic MtF are screwed due to poor estrogen signaling, they want to be women while being "immune" to estrogen.
>>41450906older post that's contradicted by fresher and better-formulated thoughts that have been mulled over more over a knee-jerk reaction to a hunch he hadhttps://www.reddit.com/r/DrWillPowers/comments/1o0n7vw/the_hidden_pitfall_of_monotherapy_and_why_dogma/it's obvious that he thought it over and now thinks otherwise, which proves that earlier post wrongcope
>>41450949What does it really change? AGPs are more masculine and less likely to pass.
>>41449859Quite possibly the most retarded amalgamation of words I've read in my life
>>41450913I never had respect for him but I definitely think this is some of the dumbest shit he's written lmao
>>41450944Not 'immune', but at far greater risk of maxing out their receptor saturation due to poor metabolisation of estrogen. This goes back to the whole thing about megadoses stalling your transition - if you're naturally insensitive to E then you risk overwhelming the body with even moderate doses. The solution, according to Powers, is to support defective estradiol metabolism with methylated B complex supplementation. Basically, helping the body to clear out weak estrogen metabolites (i.e. 2-hydroxy) so that the receptors can potentially be freed up to absorb more potent forms, such as 17ß Estradiol. Additionally, lowering SHBG becomes more necessary, so that those with low estrogen sensitivity can free up more E2. Who knows whether he's right - I match the description he's given, so I'm about to start a new regime that incorporates metabolism support (NAC, creatine, Vit B complex) and combine this with boron supplements to lower SHBG. I'm interested to see what will happen.
>>41450998proof?again see >>41450899cope harder
>>41451112how do you know if you're naturally insensitive to e?
>>41451169Powers himself often relies on the genetic data of his patients, and looks for certain pointers there (there's more info on this on his subreddit). I think a lot of his hypothesis is based on observational data, though - there are common traits amongst his patients that seem to suggest estrogen insensitivity (the most obvious being, obviously, a poor response to exogenous estrogen despite otherwise perfect levels). He notes that those who are naturally dainty, often very skinny and tall, and who - weirdly - have a high tolerance for stimulants will often be poor estrogen responders. There are also seemingly correlations between those with conditions such as ADD and autism, as well as those who are anxiety or depression-prone. They seem to all typically have a similar story of seeing strong progress in the first 6 months of HRT and then seeing a plateau after that, as their body reaches estrogen saturation and absorption of E2 becomes frustrated. There's unfortunately little more than speculation here at the moment, but there are interesting anecdotes posted by people on the subreddit from people who matched that profile taking metabolism support supplements, reducing SHBG and unstalling their transition.
>>41451316i dunno if that's me, i'm 5'8 and i consider myself pretty tall, plus i do have a high metabolism and am quite "depressed"though, coffee keeps me up for about 7-8 hours past my bedtime before tiredness takes mesorry anyway, you're not a doctoralso i have c cups but i dont think that means anythingits whatever i dont think i am enough of an autist to research this stuff right now anyway
>>41451403Yeah, I mean there's also the fact that what some people regard as 'stalling' is basically not being fully transfigured into a cis female within 3 years of starting hormones. There are limits to HRT's effectiveness regardless of your own sensitivity to it, and it can be easy to assume that there's a missing part of the puzzle holding you back, when actually it'd be better to come to terms with the reality of the situation. Ultimately, the supplements being recommended are in general going to benefit you whether you're estrogen insensitive or not, so it's worth giving it a shot. That's my thought, at least.
>>41451443yah, i guess my fat distribution kind of sucks, but i dunno if it's because i just never gained much weight (i tried and it mostly just went to my boobs)my hips arent tiny but they are just like hard with no fat on themi guess ill think about giving some of the supplements a shot, anyway
>>41449859That's not what he means. Trans lesbians (there is no such thing as AGP, blanchard was retarded and confused with cross dressing fetishists) have poorer estrogen receptors. He uses thin upper lip as example. HSTS have lower aromatase. If they take pure Estrogen (not not T) they are fine but the transbians are not.
>>41451736cont. Here is another famous trans activist (Mallory Moore) Note the gum showing. As soon as you see the transbian phenotype it can't be ignored. I can go on forever. But anyway, thick dick sucking lips is usually HTST and thin lip is not.
>>41451736>>41451781>have the malebrained phenotypeis it over for me?
>>41451736im gonna be honest this just looks like some cisfoid
>>41450871>>41450944>>41451736Ah so my sexuality (borderline ace, but any attraction is exclusively to women) is the aberration in his theory.Or am I the world's first HSTS lesbian? Blanchard BTFO>4'11.5", crazy narrow frame, pretty solid response to estrogen>>41451781White people exist nona
>>41449859>absolute honkersWhat I love about Dr. Powers is his dedication to medical professionalism at all times
>>41451809There are ways to solve it. For example your liver may produce high SHBG which is blocking the estrogen. There are other ways too. SHBG btw binds to DHT so taking finasteride may block your transition too. HIgh DHT may transition someone as it causes more free E. It's complicated.
>>41449859Hsts isn't real, all trannies are agp
>>41451886I don't know anything about this stuff so idk what you're talking about, how do I counteract SHBG?
Hussies clearly have better outcomes, both prior to and after transition, owing to their phenotype.
>>41451896I don't know I'm using AI to figure it out. along with Will's data. There are a lot of factors.
>>41451889hsts can have both agp and aap
>>41451736dylan mulvaney was gay prior to transition with thin lips, very low bf% and early wrinkles. i always found him to be a strange case.
>>41451932Be careful. I posed a weird endocrinology question/asked AI for an explanation for a weird finding and it straight up hallucinated both a claim and multiple studies to support it. And when pressed it would apologize, think about it, and hallucinate a couple new studies while repeating the completely unproven claim.Over and over again.I'd easily trust Dr. Powers over an LLM.
>>41451781I have thick lips and I am extremely AGP.
>>41451736That doesn’t make any sense, lesbians like women because they’re male-brained.
>>41451736>>41451781I have very luscious lips and I only like ftms
>>41452224He says male-brained is having a High estrogen receptor young. If he gives a mtf a high enough dose before the brain is complete they detrans and turn straight. He notices tiny, big lips, (pooner phenotype) start out as lesbian but if gives them T they suddenly want cock. He gae an example of someone telling him to fuck off with his theories who then fucked 3 guys and needed prep.
>>41451896SHBG increases in response to large influxes of hormones - it’s basically a regulatory function to stop you getting cancer, absorbing and neutralising excess quantities of T, E, and other hormones. It will preferentially bind to T/DHT, but will bind to E if you’re at castrate levels of the former. You ideally want SHBG to be at below 120, and above 90 or so, for good results - this way you’re maximising the amount of free E2 in your system. If your SHBG is above 120, it’s probably a sign that you’re dosing too high. To solve this, you ideally need to flatten the peaks and troughs of your injection cycle - rather than doing 12mg every 10 days, switch to 6mg every 5, for example. The lower peaks but median higher estrogen levels will mean less of your E is binding to your SHBG, giving your body more E to make use of. You can also try boron, which binds to SHBG instead of the estrogen, which can potentially raise your free dominant hormone levels by up to 10% or so. You basically want to be aiming for a Free E2 percentage of around 1.5%-2% (the higher the better). Some people also use Tongkat Ali.
>>41452251I’m dating a ftm with gynephilic fenotype, is it over? He told me he was straightt. Mtf
>>41452293This was the post.
I'm super male brained and really ugly and don't pass and have small boobs (I'm straight tho)
>>41452377I want to cuddle you.
>>41452270So shouldn't guys who drink alcohol masculinize more because it isn't binding to DHT/T during that duration.
>>41450883being a rapebian is fembrained and valid UwU
>>41449859Will>I can fix himPowers
>>41452398why
>>41452470this is true but only because elon is a retard
>>41452491>this is true but only because elon is a retardwhich is exactly why it'd fail>I know absolutely without a shadow of a doubt I could sit down and spend 10 minutes with Elon musk to change his mind for 10 minutesis more appropriateto think the worlds richest man acts as he does for lack of adequate "data" is farcical
>>41452470what did he mean by this?
>>41450949i have the slit thing he mentions here what does it mean? i think im sensitive to estrogen but im not mtf im just a gay femboy>>41452470>>41452491will and elon have very similar personalities now that i think about it
>>41452572has anyone tried baiting him into rationalizing the holocaust yet
>>41452572based
>>41449859do you want me to ask him about it? I see him every month >>41452572he is VERY based
>>41452612>I know absolutely without a shadow of a doubt I could sit down and spend 10 minutes with Hitler and show him everything that I know from genetic sequencing and the dude would have his mind changed. When the only data set you have is negative, that's all you know.this would be funnier
>>41452613>>41452624>le basedbut>Ignore the institutional transphobia, manufactured psyops, lack of medical care, social othering and general transphobia. Those aren't barriers to living your life as a trans person.>You trannies are responsible for your own actions and the data here in the cass report absolutely destroys your position. Data is not transphobic, it's just data.ok
>>41452414I don’t think so. From my very poor layman’s knowledge, this is because SHBG binds preferentially to T. The feminising effect of alcohol are due to SHBG binding to the T rather than the phytoestrogens in alcohol, leaving them to be absorbed by the tissue.
>>41449859dr will powers is not the quack you think he his you havent even read into his theories. comparing him to blanchard is a horrible insult to him and his work
>>41452251>He gae an example of someone telling him to fuck off with his theories who then fucked 3 guys and needed prep.Kek, I remember this anecdoteIt was top bait, the Powers seetheposting from pooners was chef's kiss
>>41452224Define male-brained.>>41452270>flatten the peaks and troughsAh I wonder if that's why mine's 177 with an E of only 147.Gonna switch (from sublingual) to injections whenever I work up the nerve. I'll report back if I suddenly become hot.
>>41452849I meant because the liver would be dealing with alcohol rather than producing SHBG or the production would be impaired. I don't think I've seen feminizing effects, all pubs guys I see are balding and look hard.
>>41452928Yes I just posted the screencap. Mea culpa. It was Six guys they got railed by, I was relying on my memory. I'm unsure if he explained why that was. Perhaps more T flips it or something?
>>41453011>Yes I just posted the screencap.Yeah I actually noticed that immediately after posting, RIP my timing, you were never the healthiest
>>41452859It was a joke anon, I like Powers
>>41449859this explains a lot about my sensitivity to sex hormones and overbearing malebrain as a hilarious neverpasser permamanmoder
>>41451736>>41451781see >>41450949powers contradicts you and he obviously knows more than some imageboard schizo
>>41449859snake oil salesman if i've ever seen one, pretty disgusting scam hes got going on.
>>41453294I don't know what you are talking about. He says in that thread low estrogenic signally is cause of attraction to women.
>>41453563he does not have scientific rigor on his side and everything he says should be taken with a tablespoon of salt, but what kind of scam are you talking about? I think he's onto some real shit
>>41452604means ur intersex
>>41451736>>41451781>>41453810Will blasting high E make me attracted to men? Unironically I don’t wanna be attracted to men. I prefer to have women as my dating pool
>be obsessed with my gender for months but not able to fully accept >read thread>read Powers leddit blurb on troon phenotype urethral openingFUCK
>>41455227
>>41456151doesnt feel right to true intersex people but desu i probably am
>>41449859Sex role behavior is governed by prenatal T. Hypothalamus response to E is governed by prenatal E. Sexual orientation is influenced by a combination of the two.Prenatal E comes from aromatization of prenatal T. Female fetuses do not have significant levels of either sex hormone.CAIS XY people have male levels of prenatal T and E, but the T is ineffective, so their bodies don't masculinize and their behavior is feminine. Their brains defeminize because of the E, giving them a male hypothalamus. They feminize just fine at puberty whether its from their internal testes producing T (which is aromatized to E) or from HRT, though.
>>41449859I think Dr powers needs to shut the fuck up about wild speculation and do actual peer reviewed research on appropriate dosaging. schedules under various ages, physical proportions, starting states, and conditions.There isn't even a consistent standard of what success means in the first place, and even less of a concept when you throw in detrans and retrans, and GNC. >>41450899>>41451146proven my ass. It's great stuff, but the APA and JCEM is where the actual science is, and his shit needs replication and rigor.
>>41459355what does this mean in 4chan terms?which combinations of prenatal t and e are trutrans and which are heccin invalid?
>>41459868To be trutrans you need to limit prenatal masculinization, which means limiting the effect of prenatal T. There are two routes to that.The first route is the testes not working properly and not pumping out enough T to masculinize behavior. A side effect of this not enough E gets produced either, so the hypothalamus remains female.The second route is partial androgen insensitivity preventing the T produced by the testes from masculinizing behavior. The T is aromatized to a normal amount of E, so the hypothalamus becomes male.Faketrans often have problems with their E receptors, so they can end up with masculine behavior and a female hypothalamus. They also tend to get poor results from HRT.
Powers is a dumbass
>>41449859may b there wouldnt be so many failed hons running around if b-hrt pellet implants were standardized
>>41460009It wouldn't help. Some people's bodies are simply poorly disposed toward transitioning.For the ones for whom it works, not all that much is needed for them to feminize.
>>41459899thank you!
>>41460093No prob.What's also interesting is there's a cutoff point with androgen sensitivity beyond which you almost always get androphilia. At lower grades it's all a bit of a nothingburger, maybe some mild hypospadias repair needed, but at higher grades things can get crazy.Anyone who uses a diagnosis of MAIS as some sort of proof of being trutrans is full of bullshit, because its effects just aren't strong enough to tip things over into trutrans territory.
>>41449859at some point y'all have to realise that Will is just some fucking GP who has terrible professional boundaries who likes to rattle off his half-baked, untested theories with little regard>>41450105your hormone levels might be out of wack, you probably should get it checked out because it can be a sign of health issues
>>41450949>tfw you will be kidnapped a chaser doctor
>>41460056Indeed.>almost 5 year sublingualhon, monotherapy for ~4 years of it>except it worked, hormone optimization be damned>attracted to women though so maybe Powers should study me
>>41459355>hypothalamusIf I remember correctly we actually have study evidence that the hypothalamus switches modes based on recent sex hormone exposure. Specifically they tested whether a jump in estrogen levels could trigger an LH surge (signal to trigger ovulation in cis women, driven by driving the hypothalamus into a positive feedback response with estrogen held above 200pg/mL), and found that it could in trans women but not in trans men.Am I missing something?
>>41460127wdym? soory im confuseddo you mean low or high androgen sensitivty causes androphilia?
>>41459405You have to do research before your peers review it you massive fucking retard
>>41462744The only studies I've seen linked it to prenatal sex hormone exposure. I'd be interested in seeing any study which indicates that it can change later in life!>>41462845At low androgen sensitivity (high androgen INsensitivity) you almost always get androphilia.
>>41449859What an actual scientists says:https://youtu.be/pOrL_zXG1_4
>>41463354I didn't get androphilia until male puberty which went insane around 17. Before it I was attracted to women. It was similar to that pooner story somewhere above.
>>41452251>He says male-brained is having a High estrogen receptor young. If he gives a mtf a high enough dose before the brain is complete they detrans and turn straight.Makes no sense. If that was real it would have long been discovered by accident in youngshit treatment we have since the 90s but mtf youngshits rarely detrans. It's the pooners who do.This also would be the holy grail cis people basically want for us to cure us. If this mechanism made any sense it would have been discovered by now because most trannies want to go on high estrogen as soon as possible.
This powers thing is going on for like 10 years but has there ever been any evidence as in timelines that show that his methods work or are superior?If it was true that he is able to 'unstall' feminization in his patients and it would lead to visible results wouldn't he or his patients be raving about them on social media and post them?All I read is some theorizing and claims.
>>41463714It also makes no sense because the pattern of activation is likely different between testosterone poking ERs through aromatase and feeding the whole system estrogen.Otherwise wouldn't puberty trans AFABs like crazy?See also: the number of people with CAIS who report feeling better on testosterone despite literally having nonfunctional (nuclear) androgen receptors.
>>41452347Does anyone have the link to the original of this? I'd love to see where he posted it and what kinds of responses he got, kek
>>41463714I suspect he believes a lot of his patients effectively are mentally male now though they have other stuff that needs fixing as well to complete it. He made a thread asking for reports:https://www.reddit.com/r/DrWillPowers/comments/1i7ov0o/a_strange_question_has_anyone_here_had_mtf_gender/
>>41452347What about long blonde hair gay boy losers. Should they transition or
>>41465201screenshot for prosperity
>>41465344This dude is just the crackpot doctor. Honestly respect him for being so ballsy pushing purely anecdotal evidence.
>>41460917>at some point y'all have to realise that Will is just some fucking GPPowers has the largest cat in the world, which he grew himself. He has a Guiness world record for largest cat and three other nearly as large cats which were earlier experiments in creating absolutely fucking massive cats. He has the world's most comprehensive knowledge on how to grow a gargantuan cat. He's not just some fucking GP, he's a mad scientist and trannies are the exact same thing to him as cats, a biological puzzle for him to optimize with his autistic craving for perfection.
>>41449859this is an oversimplification of an already oversimplified position
>>41465067bamping this request
