>>43221329
does this actually do anything for non diabetic males tho? idk if ive seen even anecdotal evidence for that

Its not good for fatmaxxers, the effect doesn't really work past about a 5-7% weight gain so really it would be better for someone who's slightly too thin and gains like 10 pounds gradually over the 4-6 month course of pio.

>>43221377
how do you know tho

Has anyone had success getting the superior lobeglitazone? Idk where to even source it like IndiaMart?

>>43221329
>>43221346
I gained ~25 lbs over 4 months on pio 30mg and can confirm by the stretch marks and pants not fitting that a lot of it went to my thighs, butt, and calves.
A good bit also went to my stomach and lovehandle area.
Started at 170 lbs and went up to 195 since starting, 5'10" height for reference.
I think I look a bit more feminine now but what I was really hoping for was gains on my hips or for my lovehandles to start to blend into my hips. I think it would happen if I gained like 25 more pounds but the tummy gains are kind of putting me off from gaining more. I'm going to stay on it for 2 more months and then probably try to burn off some of the weight to get me back down to 180-185.

>>43221509
A bit of a mummy tummy is normal. I;'ve heard from other anons you need to spike your E above normal

>>43221537
Yeah I keep my E levels pretty high my tests put me around 450-550 pg/mL at mid cycle for EV weekly injection

>>43221379
are there health risks associated with pio? i have some sitting around but im on a lot of meds now so im scared to add it to the regiment

>>43221644
Go for it Nona! Supersize yourself

>>43221329
It'll work with or without estradiol.
I'm on no HRT and my WHR has gone from 0.84 to 0.81 over the past 4 weeks while gaining on pioglitazone.

>>43221447
lobeglitazone is lobeshitazone

>>43223692
Why do you say this?

>>43221447
The only way to get it is from either okderma.com, and or indiamart. However lobeglitazone doesn't impact osteoblasts at all in a negative aspect, which is infact kinda terrible, because of the fact that ppargamma uses msc stem cells which mscs are used for recovering of osteoblasts in bone marrow, so that means if the osteoblasts have not changed that entirely means that no msc stemcells have become subq adipocyte tissue, which is why pioglitazone is superior.

>>43221329
Me want how get

>>43221644
there are many, including all types of edema increase in overall Heart failure, and osteoporosis/bone fracturing, at around 5%bone density loss every year. So my honest recommendation is you either do 6 months on, 5 months off, or you workout during this time period that you are taking pioglitazone in general to lower overall risks associated with tzd usage.

>>43223764
grug go to aipctshop
get white circle pill

>>43221379
uh i could gain that without pio easy

>>43225614
Pio doesn't really make it significantly easier to gain weight, its about having that weight be disproportionately feminine subcutaneous fat

>>43221329
>Pio combined with Estrogen is a great option for weight cyclers or fatmaxxers or even just height anons trying to bury their skeleton in soft fat
so real
i love pio, i love gaining weight, ive been thinking of upping my dose since im having alot of calories, high dose might be more useful
currently on 15mg a day
any smart people have suggestionss? :p

>>43226068
30mg is more effective but its already diminishing returns and the higher and longer the dosage the more you're probably increasing your bladder cancer risk

>>43221329
hey thanks for using my screenshot. You should also take pio when you are losing weight. a lot of people forget that.

>>43226068
yea you totally should be on 30mg

>>43226068
Cow if your getting it off the internet go see instead DR Hayes he is willing to write a script for it and it’s only $10 to fill vs stupid shipping costs.
T. Sydfriend

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After making sure I had stable levels on E I started fatmaxxing to grow boob & ass to pretty decent results
My natural fat distribution has always been concentrated to butt & thighs
I also stopped working out cuz I was pretty fit & didnt want my pecs or buff legs to detract from my girly squish
So I went from perma 180 weight while dropping muscle & finally pushed up to 200lbs

So if I wanted to start pio whats the play here? Should I drop weight & then push up again? Should I start adding in squats instead of just walkmaxxing? Is it taken orally or whats the ideal roa
It sounds like its still beneficial even if I have naturally feminine fat distribution based on this thread so now im kinda interested

Thnx anons

>>43226014
doesnt e do that too?
pio sounding like a psyop

>>43221329
Please elect me to congress so I can start illicitly injecting this into anyone with an R next to their name.

>>43228842
stupid cocksucker look at the fucking studies in the op screenshot. its proven that it effects fat distribution. Some cis women gained weight and still LOST belly fat.

>>43229696
pics or it didnt happen

>>43221329
This does not work. Pio's effects for encouraging visceral fat loss and subcutaneous fat gain only work with obese diabetics, not healthy responders. Even then it's a modest result. For a healthy responder taking Pio on this basis, you're unlikely to notice any change at all.

You're also ignoring how fat distribution actually works and encouraging people to 'fat max'. Please understand that, even if Pio worked like this, you can't control fat distribution. Your fat distribution is primarily individually based and has an order of priority. You could bloat up your abdomen or arms or face or back before any fat deposits into your thighs, hips or butt because of your genetic predisposition. It is true that there are generalized trend between male and female for fat distribution, and estrogen will promote a more feminized trend, but it won't overwrite your genetics. You can't spot increase fat or control where it goes. Also, for those that didn't know, you need to be on estrogen for over a year to feasibly change your fat distribution and at that point it'll begin 'shifting' fat even if you don't lose/gain weight gradually.

If you want a nice body here is what you CAN do:
1. Take estrogen for over a year
2. Resistance training to build your muscles (glutes, hamstrings, etc)
3. Introduce a SMALL caloric surplus after a year to start gaining weight if you're particularly thin

Exercise is the only consistent way to get results. Estrogen will marginally help you fill out your figure. Do not rely on the examples of others because you can't replicate someone else's fat distribution, it's literally impossible. The survivorship bias and placebos are the only 'evidence' of Pio working while literally every study counteracts it because Pio can't consistently replicate this effect in non-diabetics.

>>43230850
>source: I made it the fuck up

>>43230893
I get that sabotaging other trannies is fun for fat people but this is basic physiology. Even cis women exercise because it's the only consistent way to improve your figure outside of surgery. Fat distribution is not something you can 'game' in a meaningful way and the results will change between every single individual person.

Also the burden of proof is on you retards with this stupid psyop that's been disproven a million times. Post some actual MRI scans to prove the change of visceral fat reduction and subcutaneous fat gain even happened with any of you. None of you would find the change happened at all. The fact is, the 'success stories' of Pio are just people who already have a more desirable fat distribution OR they're confusing the results of Estrogen to be Pio.

Also literally every study on Pio mentions that it's specifically for obese diabetics, not healthy responders. There are no studies to prove Pio has any significant effect on healthy people.

fat fetishist thread, i feel bad for the nonas that are going to become obese and disgusting by doing this

You know what actually reduces visceral fat without particularly targeting subcutaneous? Diet and exercise. Aerobic exercise in particular on a caloric deficit will (typically) eradicate visceral fat first. But I guess you all are too lazy to go to the gym ohohoho

>>43230931
This is on par with saying that HRT doesn't change fat distribution. Changes to signalling pathways in the body can lead to changes in fat accumulation. No huge shock there.
>Also literally every study on Pio mentions that it's specifically for obese diabetics, not healthy responders
Ok? Lots of studies "mention" things peripheral to the central findings of the paper, folk wisdom exists in research fields too. Especially doctors and medical researchers, who have a tendency to firmly say something is not the case until it is explicitly proven.
I don't really have any interest in Pio, it's just weird seeing people spaz out about it.

>>43231046
Already optimized my lifestyle for this but my viseral fat was still not as low as I'd like according to dexa so pio was a good choice for me. Also my fat distribution was kinda stuck in between at like a early T trans man

>>43231059
I get what you’re saying about signaling pathways, you’re right that changing them can affect fat distribution and that’s basically how HRT works, but I think the issue here is more about magnitude and evidence rather than whether it’s possible in principle, because HRT directly changes sex hormones which are one of the main regulators of fat distribution so the effects are consistent and noticeable, whereas pioglitazone works more indirectly through insulin sensitivity and PPAR gamma and the effects seen in studies are relatively modest and mostly in people who are already insulin resistant or diabetic, so it’s not that people are claiming biology can’t do this, it’s that this specific drug doesn’t seem strong or reliable enough to produce the kind of cosmetic changes people in the thread are expecting.

I think the comparison to HRT is where it breaks down, because HRT is acting on a primary driver of fat distribution while pioglitazone is acting on a secondary metabolic pathway, so even if it has an effect it’s more about normalizing fat storage in people with metabolic issues rather than pushing a healthy person beyond their baseline in a noticeable way.

>>43231103
Pio won't do much for you unless you're a diabetic, but I can't assume what your circumstances are.

>>43221329
it doesnt work that way op

honestly isn't this the same pseudo-scientific conclusion that those retards who promoted zinc did?

people thought zinc would make you cum more because, for some people, having more zinc made them cum more. what ended up being the case is that the people who responded positively were DEFICIENT in zinc to begin with. so it was never that "zinc makes you cum more" but being deficient in zinc makes you cum less.

in this case, it's not that pio has this effect for everyone. it's that for people who have insulin problems pio will return them closer to their baseline health.

>>43231131
It has a reasonable mechanism which could theoretically work in non-diseased people. If people want to play lab rat with themselves with something relatively safe with a plausible reason it might work, go wild. Normies do all sorts of things for their health which has even less scientific support than that.
>Pio won't do much for you
"won't" is far too sure wording. I'm sure doctors will tell you "won't" as well because they don't want to get sued when someone swallows a whole bottle of it to become a real woman or whatever, but it's not the appropriate confidence level.

>>43231131
I already did a cycle and it did reduce my visceral fat more than the margin of error for dexa.

>>43231188
Unless you took MRIs before and after I seriously doubt that, you can't reliably approximate your visceral fat that easily. Also, you really just don't know what factors led to any fat loss. I'm sorry but anecdotal evidence is largely weak here as your fat distribution is specific to you.

>>43231187
You're arguing for people to do something as unhealthy as rapid weight gain through 'fat cycling' and take Pio which has proven health risks for a result that's not only based on massive jumps in logic but has no evidence for. I am amazed at how people can justify the blatant sabotage of other's health. Instead of doing things that work, you feel that people should make themselves lab rats while over promising results despite there being much more anecdotal evidence of failure than the few anecdotal success stories. Make it make sense.

>>43231187
I get what you’re saying about mechanism, it’s true that pioglitazone has a plausible biological basis for affecting fat storage, but the issue is that “theoretically could work” and “produces a meaningful or predictable effect in healthy people” are very different standards, especially when most of the evidence we have is in insulin resistant or diabetic populations where it’s essentially normalizing metabolism rather than pushing it beyond baseline, so when people say it “won’t do much” they are usually talking about expected effect size and reliability in normal physiology rather than claiming absolute impossibility, and in that context the confidence is coming from the lack of strong, reproducible data in healthy users rather than just medico legal caution.

I hate these threads. Pio obviously doesn't work that way. I'm tired of fat fetishists shitting up the board.

I think people are forgetting that by becoming so obese we can become diabetic and then pio will work :D

>>43221329
So basically you want to pair this up with putting clobetasol on your tits and taking prog. There are some more things you could add in the mix like boob suction but thats the gist. I've seen some pretty impressive growth from girls that do this but I would absolutely not do anything of this your first two years.
Your first two years you should really just be trying to keep a good calorie surplus and then once you go mono and get prog like 1.5 to 2 years in you should start weight cycling. I did this and it got me a fat ass and solid B cups when both were flat before. I'm starting to add clob just to see if I can get these Bs to C or D.

A lot of girls from my discord used this stuff to great results but it seems like some of them got tubular tits so I'd really wait until you fill out more on your own.

File: fat distribution dexa scan.png (500 KB, 711x800)

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>high serum E2 drives adipocyte hyperplasia in rodents, with peak adipocyte creation occurring at the peak of the estrogen cycle on a high fat diet
remember to lenamaxx, drink peanuts, and avoid sugar on your weight cycle!
also look into clobetasols effects on MSC -> ASC conversion
https://pmc.ncbi.nlm.nih.gov/articles/PMC10567995/

>>43231187
>Reasonable mechanism
Yes...
>Theoretically work in non-diseased people...
Nope. The mechanism is based on the disease, that's where I think you're confused. You're not going to produce results with a mechanism that requires you to have insulin issues lol

>>43231340
>and taking prog.
for reasons posted above you dont wanna run prog while on clob. prog suppresses E transcription.

>>43231311
>>43231300
>>43231257
>>43231231
I've never seen anyone this mad about pio before. Did your gf get a better body with it then dump you or something?

>>43231340
Oh to add to this my starting weight was like 140 and I kept a full calorie surplus for two years and hit 160 and started seasonally gaining and losing weight.
Last summer I came down from my winter 165 and once I hit 135 and started gaining again my tits shot up. I've struggled to get past 155 this year unfortunately so I'm pushing gaining into the spring.

>>43231340
nice try, chubby chaser

>>43231391
Im a lanky (usually) 5'10 twinkhon

>>43231365
>PPARG's only function is in the context of diabetes, it has absolutely no other function
>conceiving of disease, especially metabolic disease, as a binary rather than a spectrum
How does it feel to be retarded?

>>43231369
Maybe I miswrote that bit I guess I'll have to double check it before I start 2 cycles of pio/clob
I have had to hold off the last 3 months because I'm getting my thyroid checked out

>>43231416
fun
go safe, nona

>>43230850
Why are you bothering? There's three fat trannies on discord circle jerking this idea, the vast majority of us were never going to take pio. You're arguing against literally no one. Most nonas are not going to make themselves fat. There was no risk.

Personally I want all ladies to become big and round

>>43221329
I love how the only evidence of this working for non-diabetics is a few cherrypicked anecdotes from some trannies whereas I get to see many, many more examples of people just becoming horribly obese by trying to fat cycle. I really think >>43228842 is right, this has to be a psyop of some kind.

>>43231521
we need a context hat style image for posters like you

>>43231340
I think you are mixing a few real ideas with a lot of assumptions that don’t really hold up when you look at how this works biologically. Hormones like estrogen and sometimes progesterone do play the main role in breast development, and weight gain can affect size in some people, but the results are really inconsistent and mostly come down to genetics and overall hormone environment over time rather than something you can reliably optimize by stacking extra interventions. The issue is that things like clobetasol are very strong topical steroids that are not meant for tissue growth and can actually cause skin thinning and damage, and mechanical methods like suction don’t have good evidence for producing lasting structural changes. When you put all of this together, it starts to look like a stack because of anecdotes, but there are too many variables changing at once to actually know what is doing what, so most of the “results” people point to are likely confounded by normal variation, hormones, and weight changes happening at the same time.

>pio thread
Vomit. Go to the gym fatties

>>43231560
idk what theyre thinking stacking all those desu. you cant use suction and clob together. thats dumb, youll destroy your skin.

>>43231571
the pio server has a gym twink for a mod in it and he swears by pio

>>43230850
sources? as an example why you need some i'll just note that hiv patients doesn't generally have diabetes or obesity.

>>43231589
Since fat distribution is primarily genetic...and Pio is related to insulin resistance...I wouldn't be surprised to learn there are rare cases where it did work out for someone. But honestly, he's probably just coping with placebo like in most cases

>>43231620
You are right that HIV patients are not typically diabetic or obese, but that is actually why they are used in these studies: HIV-associated lipodystrophy is itself a metabolic disorder caused by antiretroviral therapy, involving insulin resistance and abnormal fat redistribution. That is also why the relevant pioglitazone literature, such as the ANRS 113 trial and other HIV lipodystrophy studies, still shows only modest and inconsistent changes in subcutaneous fat rather than any predictable or cosmetic reshaping effect. The broader pioglitazone literature, including studies like PROactive and Miyazaki et al. in type 2 diabetes and IRIS in insulin resistant but non-diabetic patients, consistently shows that the drug tends to shift fat storage in metabolically abnormal populations, but these effects are modest and heavily dependent on underlying insulin resistance. There is very little evidence in truly healthy, insulin sensitive individuals that this translates into meaningful or controllable fat redistribution, which is the key gap when people try to generalize it into a cosmetic effect.

>>43231641
>Since fat distribution is primarily genetic
you are profoundly stupid

>>43231666
When people say fat distribution is primarily genetic, they are not saying environment or hormones do nothing, just that genetics sets the baseline pattern your body tends to follow. This is well established in basic physiology and supported by twin and family studies showing strong heritability in where people store fat, such as abdominal versus hip and thigh distribution. Hormones like estrogen, cortisol, and insulin sensitivity can shift that pattern to some extent, which is why things like puberty, HRT, or metabolic disease can change body composition, but those changes still operate within limits defined by your underlying genetic setup. That is also why two people can do the same diet, training, or medication and end up with very different fat distribution outcomes.

>>43231666
...are you stupid?

>>43231687
>>43231702
do you understand what a drug is?

>>43231709
so you are stupid. got it.

>>43231589
>the pio server
does it allow chasers? i like fat girls desu

>>43231620
the other guy's reply was very wordy. basically:
HIV havers have metabolic and insulin issues too, that's why it had some positive results.
hope that helps

Thread summary!

Pro-Pio logic:
if a drug changes biology in sick people, it can be used like a sculpting tool in healthy people!

Anti-Pio Logic:
If you don’t have the medical condition it’s meant for, it’s usually not worth taking it for body-shaping purposes because the effect is unreliable and the risk is not zero.

My logic:
I don't like fat chicks so don't take it

>>43221329
i’m gonna buy some in a few days

how many should i buy for a solid supply without being suspicious? idk how long i’m supposed to take it for

but i should also lose weight before taking it right? i’m at 85kg rn at 184cm, how much should i lose to have a nice effect? or can i take it even while losing weight?

>>43232163
How long have you been on estrogen? I'd temper your expectations with Pio btw, it's been discussed above but it's basically just not worthwhile for most people is the gist of it.

>>43232163
Don't take it past 6 months, you get the majority of the effect by 3-4months

>>43231823
I took it as an unweight twinkhon, I like the results, but anecdotal ymmv

>>43232163
it doesnt work like that

>>43231823
Took pio as a underweight girl and still an underweight girl with better fat distro, granted I feel like death.

>>43233480
could be your insulin issues dawg unless yo on estrogen in which case the more likely culprit

>>43233525
I've been on estrogen for yoinks only added pio a year ago, pretty happy with it but was minor, I chalk up my changes to family history of obesity and diabetes but I've always been the underweight one in the family.

>>43233480
Yea lots of trannies have imparied metabolic function even when skinny ao pio might still be effective

>>43233553
Gave me a nice butt and took an inch off my waist while staying same weight so pretty happy, wish did more for boobs but oh well.

>>43227186
okii i will
>>43227215
OMG ILYSM THANKYOU!!! i will go check him out your amazing <333

doesnt work

>>43230850
nah ur right and even if your not im still going to do this because its actually fucking reasonable and not retard science. even if i end up wanting pio i will do this first to make sure i have all the right levels and starting point for maximum effect. why would you do otherwise when cycling more than six months in a lifetime increases risk

>>43233041
about three years now

>>43233138
oh okay thanks a lot, how many pills would i need for 3-4 months?