I think y'all worry too much about your E2 dose, when the only thing you should care about is whether you T is suppressed.having high estrogen levels won't make ur transition faster. having no testosterone WILL make your transition faster.your goal is to get your estrogen levels above 100-150 pg/dL AND get your T below 20ng/dL.I think the reason why everyone wants stupidly high estrogen doses is because ur anti-androgens are not doing their job, so you have to monotherapy (spiro sucks sadly).I have a "hondose" (3mg oral E2), but I am on GnRH agonists so it doesn't matter because my T is so fucking low I am feminizing very fast.since my hormone levels are on "cis female", spiro actually helps me with skin oiliness (search on /r/spironolactone, plenty of cis women using spiro to fix their acne)tl;dr: hondose is not real as long as your T is suppressed properly
>>43404150castration level is 50ng/dl nona don’t spread anecdotal honscience. Yes gnrh + E2 is good. Yes you need less serum E2 with gnrh or other AA
>>43404150I believe most are on monotherapy so they don't have to take AAs. Hon dosing would be taking a low amount of E and doing fuck all to suppress T.
monoterapy suppresses your T, though
>>43404150Should I just use blockers even with E injections to be sure that T is suppressed?
>>43404216You have to get labs to be sure 100% sure. What's your dose? If it's high enough it's *probably* suppressed.>>43404172who tf is nona. anyway you missed the point, it's not about the estrogen levels, it's whether your T is suppressed. If you can't get a good blocker you have to use a huge estrogen dose (because E2 has antigonadotropic effects when levels are high enough)>>43404190At big doses, which you can avoid with blockers.
>>43404428but why avoid high doses if you can just take E with none of the side effects? lol
>>43404428>who tf is nona.
>>43404150If both of them are bottom tier your bones start crumbling
>>43404442because high E2 levels increase the risk of VTEs and shit, especially when using oral.that's the reason endos never want to increase your estrogen dose (it's still stupid because trying to avoid risks they hondose you)
>>43404442That can take a little longer. As dumb and trickable as our biology is with hormones, a one time high E dose is something that could happen in nature due to eating weird organ meat and our bodies will shrug it off, it takes a week or two without blockers of high E for feminization of cells to fully kick in. With blockers it happens within days
>>43404150>3mg oral E2the humble limitations inherent to oral dosing estradiol:
>>43404456lol
>>43404468>because high E2 levels increase the risk of VTEs and shitrisk of adverse health consequences with AAs is way higher so irrelevant>>43404479who cares lol you'll be taking this shit for the rest of your life, whats a few weeks?
>>43404150>your goal is to get your estrogen levels above 100-150 pg/dLnot to be confused with pg/mL ofc
if you are on oral that e2 is being converted to e1 (estrone)
>>43404486oral sucks yes and I'm trying to get injections, but my point still stands>>43404456is nona a namefag or something?
>>43404513why yes,yes it is.
>>43404498Depends on the AA-GnRH agonists are stupidly safe-CPA is safe-ish if your dose is low (which still suppresses T)-Bica I don't know-Spiro is safe too but it's really bad at being an AA.>>43404510https://pmc.ncbi.nlm.nih.gov/articles/PMC8764217/>"Change in fat percentage and breast development in trans women were not associated with estrone concentrations nor with administration route. Therefore, measurement of estrone concentrations does not have a place in the monitoring of feminization in trans women."
>>43404549is it just breasts or is it that if its not changing breasts that means that estrone vs estradiol is a non issue for everything else too?
>>43404663high estrone is associated with bad shit as well, that's why endos are so adamant when increasing oral doses if you don't need them.but as long as your T is suppressed you will feminize even on oral.
>>43404513It's anon backwards, the typical singular address of anyone posting who isn't namefag/OP, though they can also be nona if you're feeling creative. It's like a term of endearment
>>43404150They got it from Reddit and repost it like it's original research
>>43404688is oral raising shbg more suppressive to T? is shbg an anti androgen?
