Hi /sci/, what is the best and current understanding on the down-regulation of dopamine / serotonin receptors? As someone with depression for 5 years now, I've really narrowed it down to having to do with the sensitivity of dopamine receptors. After being flooded and burned for years is it possible they can recover or up-regulate? My grandiose and cortisol thinking from my adolescence has destroyed mine beyond repair. What do we know or understand about this aspect of neurochemistry? And more-so can anything be done about it?
>>16805938There is no evidence that depression is the result of physical factors, especially regarding dopamine and serotonin regulation. UCL's study of decades worth of research recently confirmed what most innately understood anyway.
>>16805946What is innately understood, at least to you? What seems innate to me is chemical theory, just based on simple up/down regulation and evolutionary mechanisms for novelty and survival. Not saying you're wrong but interested to your theory.UCL's study was mostly about serotonin anyways, which I agree has little to do with depression. Dopamine is much much more likely the culprit.
>>16805938You haven't narrowed it down to 4chan? Stop coming here. You know this.
>>16805957The culprit is not physical factors. You are depressed because your life sucks, or you think your life sucks, or you simply don't like stuff. If you want a chemical solution to these issues, there are plenty.
>>16805938I'd be willing to talk with you in detail about this OP, but not on 4chan. I cant bother with these eternal captchas. Drop a discord or smth.
>>16805938depression is not rly a disease of dopamine receptors, its rumination circuits forming in the prefrontal cortex, these are neural "devices", physical networks of neurons in your brain that reinforce negative thinking, sap the joy out of everyday things, make it hard to feel accomplished or proud of anything, etc. Depression is so challenging because the symptoms are natural in origin, caused by the person's prolonged suffering. If you want to test this, take adderall, it will instantly and 100% cure your depression, but the effect is only temporary. And if you take it long enough, you will find that you can still feel depressed even on strong stimulants. Depression is about behavioral change translating to eventual physical change in the brain. SSRIs do not have a clear mechanism of action on depression, desensitizing serotonin causes paradoxical upregulation in some cases and in other cases it seems the emotional blunting is actually important. Probably because it causes altered signaling to other brain regions like the VTA, there's so much we just dont know about the very fine, biomechancial level desu, but the overall concepts are clear I think
>>16805938All mental illness is on a gradient of activity Its just metabolic, entirely
>>16806178I actually tried Adderall, but truthfully at any dose it made me feel worse. The best way I can describe how Adderall made me feel was zombified, I could just sit on the couch and stare blankly at the wall, very emotionally mute. and also easily irritated.
>>16806069Please do420cutupkids
>>16805938Our brains are made of gore octopoids making us SUFFER
