The paper titled "Unprecedented Persistence of Vaccine mRNA, Plasmid DNA, Spike Protein, and Genomic Dysregulation Over 3.5 Years Post-COVID-19 mRNA Vaccination,” presents the most comprehensive COVID-19 vaccine injury case report to date involving >40 emergency department visits, >200 specialist encounters across 18 medical disciplines, >100 laboratory investigations, >100 imaging studies, and serial blood and tissue sampling performed at multiple timepoints over more than 3.5 years.The findings reveal longitudinal molecular evidence that vaccine-derived mRNA, plasmid DNA fragments, and spike protein persist in human blood and tissue more than 3.5 years after vaccination independently confirmed across multiple laboratories using diverse analytical methods.https://zenodo.org/records/18460099Authors suggest that injection with modRNA/LNP gene therapy leads to permanent genomic instability and transcriptomic dysregulation, meanwhile vaccine-derived mRNA, plasmid DNA fragments, and spike protein following mRNA vaccination persist in body for long years.Authors employed ELISA and immunohistochemistry for spike protein detection; RT-PCR, PCR with Sanger sequencing for vaccine mRNA and plasmid DNA; whole-genome sequencing, transcriptomic profiling, and mass spectrometry for genomic dysregulation.This persistence defies expected rapid vaccine clearance, risking chronic inflammation, genomic instability (variants in cancer-related genes), and multi-system disorders, warranting scrutiny of long-term vaccine safety.
I wasn't really buying the whole vax thing but I know at least 4 people who suddenly got cancer within the past 3 years
>>16904721>Hulscher>McCullough>/pol/tard crossboard spamhttps://archive.4plebs.org/pol/thread/527652330/
>>16904770Don't focus on negative, seek positive. If cancer becomes wide spread in working age people, the chance that we will fix it once and forever grows.
>>16904849>Don't focus on negative, seek positive. If cancer becomes wide spread in working age people, the chance that we will fix it once and forever grows.Vaxxgolems are absolutely going to talk like this when they find out their handlers intentionally gave them cancer.
Reality:A 2024 systematic review found vaccine artifacts persisting over a year in fluids/tissues across studies.https://www.preprints.org/manuscript/202507.1359Another detected S1 protein in monocytes up to 245 days in 50 vaccinated with PASC-like symptoms.https://www.medrxiv.org/content/10.1101/2024.03.24.24304286v1A PMC paper reports long-lasting mRNA/spike in tissues/circulation.https://pmc.ncbi.nlm.nih.gov/articles/PMC11169277
>>16904873Propaganda:FDA Briefing Document for Moderna mRNA-1273 (Dec 17, 2020): "The estimated half-life for mRNA after injection is approximately 8 to 10 hours, before degradation by native RNases in the body."https://www.fda.gov/media/144452/downloadWHO explainer for Pfizer/BioNTech COMIRNATY (Jan 18, 2021): "As this is not a live virus vaccine and the mRNA does not enter the nucleus of the cell and is degraded quickly."https://www.who.int/docs/default-source/coronaviruse/act-accelerator/20h20_18-jan_comirnaty_20235b_jobaids_vaccine-explainer.pdfWHO explainer for Moderna (Feb 24, 2021): "As this is not a live virus vaccine, and the mRNA does not enter the nucleus of the cell and is degraded quickly, it is therefore biologically..."https://cdn.who.int/media/docs/default-source/immunization/covid-19/21054_moderna-vaccine-explainer_24-02-21.pdfEMA on CureVac CVnCoV (context from 2021 rolling review): "The mRNA from the vaccine does not stay in the body but is broken down shortly after vaccination"https://www.ema.europa.eu/en/news/ema-ends-rolling-review-cvncov-covid-19-vaccine-following-withdrawal-curevac-ag
Reality:Pfizers rat data post-IM injection showed LNP-mRNA in liver, spleen, adrenals and ovaries.https://pmc.ncbi.nlm.nih.gov/articles/PMC10812935A 2025 bioRxiv study in mice confirmed circa 50% of IM-injected LNPs traffic systemically to liver/lungs/spleenhttps://www.biorxiv.org/content/10.1101/2025.04.21.649878v1.full-textHuman studies detect mRNA in blood up to 28 days and tissues (heart/lymph) to 30 days post-IM.https://pubs.acs.org/doi/10.1021/acsnano.4c11652NHP imaging reveals rapid LNP spread beyond muscle to organs.https://www.sciencedirect.com/science/article/pii/S1525001625000127LNPs in Pfizer/Moderna mRNA vaccines distribute systemically post-IM injection, reaching liver, spleen, adrenals, ovaries, heart, lungs, kidneys, and brain, crossing BBB.https://pmc.ncbi.nlm.nih.gov/articles/PMC8791091/Recently CDC-published rat biodistribution for Pfizers ALC-0315/ALC-0159 lipids confirms accumulation in multiple organs, with brain penetration xDhttps://www.cdc.gov/acip/downloads/slides-2025-09-18-19/06-el-deiry-kuperwasser-covid-508.pdf
>>16904885Propaganda:UChicago Medicine (Sep 17, 2021): "The vaccine stays in your arm and nearby lymph tissue while you make your immune response and is completely gone within a few days."https://www.uchicagomedicine.org/forefront/coronavirus-disease-covid-19/7-myths-about-covid-19-vaccinesMississippi State University Extension Service (2021): "Muscle tissue also keeps the vaccine components localized, meaning that it stays in the arm muscle and rarely moves anywhere else."https://extension.msstate.edu/publications/the-science-vaccines-how-the-covid-19-mrna-vaccine-helps-your-immune-system-fight-covid-19Open Forum Infectious Diseases / Oxford Academic (2021, on pregnancy hesitancy): "The intramuscularly administered vaccine mRNA remains in the deltoid muscle cell cytoplasm for just a few days before it is destroyed."https://academic.oup.com/ofid/article/9/3/ofab433/6353950UCSB News (Mar 1, 2021): "The mRNA vaccines are injected into the deltoid muscle of the arm. The mRNA enters local muscle cells; it does not circulate..."https://news.ucsb.edu/2021/020191/covid-19-prevention-and-intervention
>>16904721
Reality:In March 2015, Jeffrey Epstein received a forwarded draft agenda for a high-level meeting on pandemic preparedness involving plans to partner with WHO and ICRChttps://www.justice.gov/epstein/files/DataSet%209/EFTA00861674.pdfThis is an email from 2017 (likely from someone working with/consulting for Bill Gates' think tank bgC3) proposing deliverables during their time there. Focus area was follow-up recommendations/technical specs for "Strain pandemic simulation", a modeling/simulation project related to pandemic strains (viral outbreak scenarios, epidemic spread modeling, or preparedness exercises), building on prior work/discussions at bgC3.https://www.justice.gov/epstein/files/DataSet%2011/EFTA02381427.pdfThis is a 2017 iMessage thread between Epstein and an apparent adviser/consultant to Bill Gates. Epstein coordinates a quick in-person meetup near Newark, suggests Gates meet figures like Bannon/Thiel/Barrack, lists the persons career options, including bgC3 role, pandemic simulation expertise and vaccine interests to pitch for Gates involvement.https://www.justice.gov/epstein/files/DataSet%2010/EFTA01617419.pdfBill Gates (via bgC3 and Gates Foundation) later co-hosted Event 201 in 2019. Event 201 was a 3.5-hour pandemic tabletop exercise on October 18, 2019, hosted by Johns Hopkins Center for Health Security, World Economic Forum, and Bill & Melinda Gates Foundation. It simulated a novel coronavirus outbreak to highlight global preparedness gaps.https://centerforhealthsecurity.org/our-work/tabletop-exercises/event-201-pandemic-tabletop-exercise
>>16904890Propaganda:April 2020. Bill Gates claims that a novel coronavirus outbreak was never simulated and we find ourselves in "uncharted territory".https://thehill.com/changing-america/resilience/natural-disasters/492470-bill-gates-the-world-is-in-uncharted-territory/
>>16904849>If cancer becomes wide spread in working age people, the chance that we will fix it once and forever grows.I dont think so xDGeneral scientific consensus for today is a claim the global population must be reduced from current 8 bln to 0.5-2 bln ASAPThe 2024 study (Dasgupta et al.) proposes an optimal global population of lower bracket 0.5 billion based on a rigorous economic model balancing population size, per capita consumption, and Earths regenerative capacity for natural resources.https://pmc.ncbi.nlm.nih.gov/articles/PMC10986754/Rees (2023): In "The Human Ecology of Overshoot: Why a Major 'Population Correction' Is Inevitable," William E. Rees argues for an inevitable reduction to below current levels (implying under 1 billion in severe overshoot scenarios) due to humanity's ecological footprint exceeding Earth's biocapacity by 1.7 times.https://www.mdpi.com/2673-4060/4/3/32A companion paper, "The Human Eco-Predicament: Overshoot and the Population Conundrum" (also 2023), reinforces this by modeling overshoot dynamics, suggesting reductions to levels compatible with pre-industrial biocapacity (potentially 0.5–1 billion) to avoid collapsehttps://www.researchgate.net/publication/365402435_The_human_eco-predicament_Overshoot_and_the_population_conundrumVan den Bergh and Rietveld: A meta-analysis of 94 population limit studies yields a lower bound of 0.65 billion under current technology, assuming strict sustainability and minimal consumptionhttps://www.niussp.org/environment-and-development/can-earth-support-4-billion-people-sustainably-and-well/Ehrlich (2018): Paul R. Ehrlich, in discussions on population ethics and sustainability (e.g., referenced in 2023 analyses), estimates an optimum population of under 1 billion to ensure high living standards while preserving biodiversity and resourceshttps://mahb.stanford.edu/blog/a-brief-on-overpopulation-why-it-matters-and-what-you-can-do-about-it/
>>16904896Crist et al. (2022) - "Scientists' Warning on Population" (published in Science of the Total Environment):This collaborative paper by environmental analysts states that a sustainable human population - one enjoying a very modest, equitable middle-class standard of living while retaining biodiversity and minimizing climate adversities - is estimated at 2 billion in lower bracket.https://www.sciencedirect.com/science/article/abs/pii/S0048969722042644Tucker (2019): Geographer Chris Tucker's analysis, cited in 2023 sustainability reviews, proposes a sustainable population below 1 billion under scenarios prioritizing biodiversity and minimal tech reliance, though he notes 3 billion could be feasible with aggressive management practices.https://overpopulation-project.com/what-is-the-optimal-sustainable-population-size-of-humans/Lianos and Pseiridis (2016, frequently cited in 2020-2025 reviews): Using an ecological footprint-biocapacity ratio (L=1 for sustainability) and targeting European-level per capita welfare ($11,000–16,000), they estimate an optimum of 3.1 billion. This is referenced in recent overviews (Overpopulation Project analyses up to 2025) as a benchmark for maintaining relatively comfortable living standards without rapid depletion of natural resources.https://www.researchgate.net/publication/282242775_Sustainable_Welfare_and_Optimum_Population_SizeBradshaw et al. (2024) – "Net Benefit of Smaller Human Populations to Environmental Integrity and Individual Health and Wellbeing" (published in Frontiers in Public Health). The study implies 2-3.5 billion as a sustainable carrying capacity for decent standards within planetary boundaries.https://pmc.ncbi.nlm.nih.gov/articles/PMC10949988/
>>16904897Pimentel et al. (cited in 2022-2024 reviews): This biophysical analysis, updated in recent sustainability debates (e.g., IUSSP and MDPI), calculates Earths carrying capacity at 2 billion with Western-level consumption or 3-4 billion at much lower levels, advocating rapid reductions of global populationhttps://scientistswarning.forestry.oregonstate.edu/sites/default/files/Crist2022.pdfWard et al. (2023) – "Demographic Delusions: World Population Growth Is Exceeding Most Projections"The study recommends restoring forced family planning to achieve below-replacement fertility (max 1.2), enabling decline to 2 billion.https://www.mdpi.com/2673-4060/4/3/34Washington and Kopnina (2022) – "Discussing the Silence and Denial around Population Growth and Its Environmental Impact" (published in World via MDPI)It estimates sustainable populations at 2-3 billion under equitable consumption, or lower (e.g., 1.2 billion using the SNQ model prioritizing 'Nature Needs Half' for biodiversity).https://www.mdpi.com/2673-4060/3/4/1009de Regil (2024) – "No sustainable paradigm is attainable without gradual population reduction"It estimates sustainable levels at 2 billion with drastic production/consumption changes, warning that even frugal living for billions is untenable long-term due to finite resourceshttps://overpopulation-project.com/no-sustainable-paradigm-is-attainable-without-gradual-population-reduction/
BTW, when NPC hears term "genomic instability", he thinks it is a form of flu and a nothing-burger. xD But this can be compared only to delayed murder.Genomic instability involves gradual accumulation of DNA mutations, chromosomal aberrations, and epigenetic changes over years, often without symptoms as cellular repair mechanisms like DDR compensate initially.https://blog.cellsignal.com/hallmarks-of-cancer-genome-instability-and-mutationIn young, fit individuals with normal checkups, these hidden errors evade detection since routine tests miss molecular-level damage.https://medschool.duke.edu/blog/determining-genetic-causes-sudden-cardiac-deathOnce a critical threshold is reached, instability can trigger rapid catastrophe.Mutations in oncogenes/tumor suppressors lead to unchecked proliferation; a dormant lesion suddenly metastasizes, causing organ failure/death.https://pmc.ncbi.nlm.nih.gov/articles/PMC4600419/Heart attack: Inherited variants disrupt ion channels like SCN5A, KCNQ1, causing fatal arrhythmias or plaque rupture without prior signs, often in sleep due to vagal dominance.https://jamanetwork.com/journals/jamacardiology/fullarticle/2782727Kidney dysfunction: Mutations affect renal genes, leading to abrupt failure, for example via polycystic disease or instability syndromes, mimicking acute shutdown.https://www.rndsystems.com/resources/articles/genomic-instability-syndromesThis "silent buildup to tipping point" explains sudden lethality in asymptomaticshttps://pmc.ncbi.nlm.nih.gov/articles/PMC4274643
>>16904721>guy gets vaxxed in 2021>gets asymptomatic mild covid in 2022 (like everyone else on earth)>gets another asymptomatic reinfection in 2023>n-antibodies fade away by 2024>researchers test him in 2025: "WHOA, no n-antibodies! but look, spike protein! must be the vax from 4 years ago!"they went from predicting mass depopulation to frantically hunting for a single molecule in a single guy (n=1) just to keep the grift aliveif this weak, scientifically illiterate anecdote is the absolute best evidence they can muster after billions of doses and years of scrutiny, it's a confession that they have nothing left.it's over. you lost. take your meds, schizos.
>>16904953This Zenodo case isn't isolated but corroborated by multi-patient studies. A 2024 systematic review documents vaccine mRNA/spike/DNA persisting >1 year in fluids/tissues across cohortshttps://www.preprints.org/manuscript/202507.1359/S1 spike detected in CD16+ monocytes up to 245 days in 50 SARS-CoV-2-negative post-vax syndrome patientshttps://www.medrxiv.org/content/10.1101/2024.03.24.24304286v1Mass spec found recombinant spike fragments in 50% of blood samples up to 187 days post-vaxhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11169277In the Hulsher et al study the patient had no N-antibodies, ruling out infections; detections include vaccine-specific modRNA and plasmid DNA (absent in natural infection), not just spike.This indicates systemic persistence in subsets, not grift. We might deal with absolute health catastrophe unleashing in front of our eyes caused by a deliberate gene therapy poisoning. It is visible in statistical data.
>>16904961>preprints lol
>>16904965Peer-review, intended as a "quality gatekeeper" (kek), can enable censorship when influenced by governments or big pharma through funding biases, conflicts of interest, and data withholdinghttps://pmc.ncbi.nlm.nih.gov/articles/PMC2663163Pharma companies fund studies, manipulate data (like omitting adverse events), and pressure journals, while governments suppress dissenting views via regulations or alterations.https://scholarworks.sjsu.edu/cgi/viewcontent.cgi?article=1087&context=secrecyandsocietyA lot of examples. Merck and Elsevier created a fake peer-reviewed journal to publish favorable drug datahttps://www.techdirt.com/2009/05/04/merck-and-elsevier-exposed-for-creating-fake-peer-review-journalIn the Vioxx scandal, Merck hid heart attack risks from reviewers, leading to 30,000+ deaths. https://time.com/6171999/big-pharma-clinical-data-doctorsGovernments altered scientific reports on climate or health to delete sensitive contenthttps://pmc.ncbi.nlm.nih.gov/articles/PMC2663163Trusting "authorities" might be lethal xD
>>16904986>EuroMOMO is a European mortality monitoring activity, aiming to detect and measure excess deaths that may be related to seasonal infections, extreme weather events, and other public health threats, in a timely manner.>Official national mortality statistics are provided weekly from the participating European countries or subnational regions in the EuroMOMO collaborative network, supported by the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO), and hosted by Statens Serum Institut, Denmark.Call me when this genocide starts.
>>16904961>In the Hulsher et al study the patient had no N-antibodies, ruling out infections; detections include vaccine-specific modRNA and plasmid DNA (absent in natural infection), not just spike.n-antibodies fade in ~6-12 months, while spike debris persists in monocytes for 15+ months after natural infectionthis means Hulscher ruled out absolutely nothing. a person tested 1 year post infection is expected to be n-negative and spike-positive. you are pointing at a standard immunological timeline for natural infection and screaming gene therapy.it has never been more over for you schizos.
>>16904992I wouldnt trust official excess mortality data published during and after 2020/2022, to be honest.A lot of examples.In 2023-2024, ONS shifted to a new method replacing five-year averages with rolling baselines like incorporating 2021-2022 data, excluding peak pandemic periods, criticized for artificially lowering excess estimates by raising baselines. World Health Network (2023) called it compromising accuracy and misinformation. ONS updated in Feb 2024 for ongoing monitoring.Eurostat (EU): Provisional data recalculated from 2024 using new completeness coefficients from national institutes (May 2025), with ongoing revisions for underreporting/incompleteness in weekly/monthly series through 2025. Data flagged as provisional/subject to change.US (CDC): provisional 2023-2025 data undergo revisions due to lags (injury deaths), 2023 age-adjusted rates dropped 6%, with potential underestimation from misclassification (race/ethnicity) and completeness issues. Methodology updated March 2023 to avoid pandemic inflation.In some countries like Russia, demographic data was recently classified. xDMass poisoning with a toxic gene therapy must result in persistent excess mortality, excess cancer incidence, excess cardiovascular health issues/deaths and in rapidly declining TFR rates. All of this is taking place since 2021.
I have absolutely no sympathy left for vaxxies. Get fucked.
>>16904999The Hulscher et al. study rules out natural infection because it detected vaccine-specific modified mRNA (pseudouridine-substituted) and plasmid DNA via RT-PCR/sequencing, elements impossible from SARS-CoV-2, which has unmodified RNA and no plasmid. xDSpike may persist in monocytes >15 months post-infection in long COVID, and N-antibodies wane in 6-12 months, but these vaccine-unique markers confirm vaccination as the source, not "standard" infection debris.
reminder: you can check all (ALL) the papers related to side effects of the mRNA vaccines hereghostbin.axel.org/paste/fy9mf
>>16905002vaccine unique markers confirm only the presence of vaccine debris, not the source of the active spike or symptom
>>16905002>long COVIDBTW, this "long COVID" thing is very controversial too.The MDPI study on PACVS identifies chronic multisystem symptoms, like fatigue, malaise, brain fog, dysautonomia, and inflammation, overlapping heavily with long COVID/ME/CFS. https://www.mdpi.com/2076-393X/12/7/790The Yale study reveals persistent vaccine-derived spike protein (>700 days) in PVS patients with similar symptoms (exercise intolerance, fatigue, dizziness, insomnia) and immune dysregulation, even without prior infection. Thus, some cases labeled "long COVID", especially post-vaccination onset without confirmed SARS-CoV-2 exposure, may actually be misdiagnosed PVS/PACVS, driven by vaccine-induced spike persistence rather than viral sequelae. xDhttps://news.yale.edu/2025/02/19/immune-markers-post-vaccination-syndrome-indicate-future-research-directions
Clotmaxxer damage control is so desperate it's surreal to watch. There's no way actual people are writing it.
>>16905007Vaccine-unique modified mRNA and plasmid DNA enable ongoing transcription/translation, producing active spike protein, not inert debris. Their persistence (3.5+ years) with spike in tissues/exosomes directly links to chronic symptoms, unlike resolved natural infection.
>>16905016the paper explicitly admits they found zero spike mrna in the skin tissue. you literally cannot have ongoing transcription or production if the instruction mrna is missing from the cell. finding protein inside macrophages just means the immune system successfully ate the foreign material and sequestered it, which is standard phagocytosis, not active synthesis.
>>16905024The study detected vaccine modRNA in circulating exosomes, allowing systemic delivery/translation in distant cells. Tho absent in skin biopsy cells, plasmid DNA persisted in skin potentially templating transcription. SP deposited in skin endothelium, nerves and macrophages plus plasma/exosomes indicates active, ongoing expression, not inert phagocytosed debris.
>>16905024You're arguing with a /pol/tard who considers himself a medical expert after browsing Twitter 24/7 for at least half a dozen years. He uses Grok to tailor replies for him.https://warosu.org/sci/thread/16835447https://archive.4plebs.org/pol/thread/520550850/https://warosu.org/sci/thread/16868840https://archive.4plebs.org/pol/thread/523394477/https://warosu.org/sci/thread/16885900https://archive.4plebs.org/pol/thread/525213280/https://warosu.org/sci/thread/16886508https://archive.4plebs.org/pol/thread/525285041/
>>16905027Less ad personam, more content, pls. Believing in what "medical experts" say, especially after 2020/2022 democide, is an act of profound faith and i am a non-believer xD
>>16905027>He uses GrokGrok and other LLMs claim that "covid vaccines" are "safe and effective", by the way. xD
>>16905026bro, transcription literally creates mrna. that is the definition. how is it templating if there is zero product? the dna is inert trash doing nothing.
>>16905036Spike protein half-life post-vaccination is short, up to a few weeks according to IDSA estimate, yet the study detects it in tissues/exosomes/plasma up to __1433__ days and it implies ongoing production, not inert debris, isnt it obvious? xDPlasmid DNA contains SV40 promoter/enhancer, driving expression in mammalian cells (concerns in multiple 2025 studies on residuals).https://pubmed.ncbi.nlm.nih.gov/40913499/https://www.tandfonline.com/doi/full/10.1080/08916934.2025.2551517Absence of mRNA in skin cells doesnt rule out sporadic transcription or exosomal mRNA delivery elsewhere, DNA isnt inert, nor trash. McKernan et al. (2023) sequenced vials, finding excessive plasmid DNA with SV40 sequences, potentially insertional.https://osf.io/preprints/osf/mjc97McKernans theory asserts that Pfizer and Moderna mRNA vaccines contain high levels of residual plasmid DNA contamination from bacterial production, often billions of fragments per dose, exceeding regulatory limits. In Pfizer vials, undisclosed SV40 promoter-enhancer-ori sequences enable nuclear entry and gene expression in mammalian cells. Encapsulated in LNPs, this DNA can integrate into the human genome via LINE-1 RT causing insertional mutagenesis, oncogenesis, and cancer. A 2025 peer-reviewed study by Speicher, Rose, and McKernan (published in Autoimmunity) that i linked found Moderna modRNA vaccine vials with residual DNA up to 6,280 ng/dose, exceeding the WHO/FDA safety limit of 10 ng/dose by _627_-fold (using fluorometry after RNase A digestion).627-fkn-fold xD It is a butchery, and now we see effects in statistics.
>>16905050>McKernans theoryBTW, McKernans theory asserts that residual DNA plasmids can _easily_ integrate into human genomes as opposed to official narrative. He claims WHO "safety limits" (10ng/dose) are completely fraudulent because even tiny amounts of functional plasmid DNA could be harmful. He argues this is due to the large number of DNA copies involved (via Avogadros number calculations), the protective effect of LNPs that extend DNA half-life and enable cellular entry, potential integration into the genome, and non-integration mechanisms like chronic inflammation or immune activation leading to oncogenesis. He cites studies like Kwon et al (2019) to support that cytosolic DNA alone can contribute to cancer even without integration. I agree with him on this.
*60 dayshttps://pmc.ncbi.nlm.nih.gov/articles/PMC11377948/Vaccine mRNA and spike proteins still detectable in lymph nodes for up to 60 days post-vaccination*up to 200 days, semen and placentahttps://www.gavinpublishers.com/assets/articles_pdf/Detection-of-Pfizer-BioNTech-Messenger-RNA-COVID-19-Vaccine-in-Human-Blood-Placenta-and-Semen.pdfDetection of Pfizer BioNTech Messenger RNA COVID-19 Vaccine in Human Blood, Placenta and Semen*up to 254 dayshttps://www.medrxiv.org/content/10.1101/2024.03.24.24304286v1Persistence of S1 Spike Protein in CD16+ Monocytes up to 245 Days in SARS-CoV-2 Negative Post COVID-19 Vaccination Individuals with Post-Acute Sequalae of COVID-19 (PASC)-Like Symptoms*17 monthshttps://www.sciencedirect.com/science/article/pii/S096758682500195XExpression of SARS-CoV-2 spike protein in cerebral Arteries: Implications for hemorrhagic stroke Post-mRNA vaccination*709 days expressing the spikehttps://www.medrxiv.org/content/10.1101/2025.02.18.25322379v1.fullImmunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination*mechanismshttps://pubmed.ncbi.nlm.nih.gov/37650258/Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS-CoV-2: Possible molecular mechanismsBrogna et althree hypotheses:1. mRNA may be integrated or re-transcribed in some cells.2. pseudo-uridines at a particular sequence position induce the formation of a spike protein that is always constitutively active. But it seems very remote as a hypothesis.3. the mRNA-containing nanoparticle will be picked up by bacteria normally present at the basal level in the blood.
>>16905050>>16905052macrophages hold inert debris for years to maintain immune memory, detection means preservation, not new production. the study explicitly confirmed zero mrna in the tissue, the dna templating claim is biologically impossible. and now we're pivoting to theoretical models (McKernan, never demonstrated in human patients) to sidestep the fact this specific patient showed absolutely no evidence of active synthesis.it's like finding a dinosaur fossil and concluding that the rock is actively breeding t-rexes
>>16905095Short spike protein half-life contradicts long-term inert debris, ELISA/IHC detect _full protein_, not just MHC peptides for memory. Up to 1433 days (!). It indicates active production, dude. Do you read/understand the study findings and what i tell you? xDBTW, macrophages degrade phagocytosed proteins rapidly via lysosomes, not store intact foreign antigens for years, long-term memory is T/B cell-mediated, not preserved full proteins.
>>16904891>Bill Gates claims
>>16905108Bill Gates, Whoopi Goldberg, Oprah Winfrey, Arnold Schwarzenegger, etc etc, all of them were top mainstream experts on pushed-up-the-throat modRNA/LNP and AVV gene therapy platforms and long term consequences they induce after getting injected in human beings. Nothing funny about this, at all. >Robert Frank, (May 26, 2009), "Billionaires Try to Shrink World's Population, Report Says", The Wall Street Journal: "The New York meeting of billionaires Bill Gates, Warren Buffett, David Rockefeller, Eli Broad, George Soros, Ted Turner, Oprah, Michael Bloomberg and others was . . . a friendly chat . . . . 'Taking their cue from Gates they agreed that overpopulation was a priorityhttps://www.wsj.com/articles/BL-WHB-1322
>>16905115>Ted TurnerThis CNN guy is a renowed expert on demography, for example.He has repeatedly advocated reducing the global population to around 2 billion for sustainability, environmental health, and to avoid catastrophes like resource depletion and climate issues.Key sources:E Magazine interview (1990s, quoted widely): "The simplest answer is that the world's population should be about two billion... If every woman... voluntarily... only [had] one child... for the next 80 to 100 years, that would reduce... suffering." (via Catholic Culture summary: https://www.catholicculture.org/culture/library/view.cfm?recnum=3486)Bridgespan.org (2013): Turner believes population must stabilize "at near two billion" to prevent more catastropheshttps://www.bridgespan.org/insights/ted-turner/for-the-sake-of-sustainability-ted-turner-makes-aBloomberg (1998): Turner advocated one-child families to reduce from 6 billion to 2 billionhttps://www.bloomberg.com/news/articles/1998-09-11/turner-advocates-one-child-families-to-combat-sprawl
>>16905101oh here we go again>Short spike protein half-life contradicts long-term inert debristhat applies to free floating protein, not trapped debris. and you know what else fades quickly? n-antibodies, which they used to determine "the patient was never infected". to prove it's actually from the vaccine, all they would need to do is extract the protein and sequence it to find the specific proline swaps. that is doable and costs about $2-5k. why didn't they do that if they think they're holding a smoking gun? could it be, i don't know, because they're grifters?>BTW, macrophages degrade phagocytosed proteins rapidly via lysosomes, not store intact foreign antigens for years, long-term memory is T/B cell-mediated, not preserved full proteins.not if the proteins are clumped, misfolded, or lipid-bound to sum it up, no mRNA = no production, and they found ZERO (0)
>>16905120The study Sanger-sequenced the detected mRNA and plasmid DNA, confirming exact match to the vaccine construct (including the 2P proline substitutions). The translated protein must have those swaps, sequencing the protein itself is redundant (and costly) when the template proves it. Plasmid DNA + pseudouridine-modified mRNA are __vaccine-exclusive__, natural SARS-CoV-2 has neither. This rules out infection far better than waning N-antibodies. Intact spike detected via ELISA/IHC (requiring native epitopes) at 1433 fkn days exceeds any plausible "trapped debris" (kek) lifespan, lysosomal degradation handles lipid-bound/misfolded proteins efficiently, long-term intact storage aint standard. Exosomal mRNA + persistent plasmid enable ongoing low-level production. How many times am i supposed to repeat myself? xD
>>16905124now you're arguing with the authors, they found no spike dna ("PCR assays for spike DNA (S1–S3) and the SV40 enhancer were negative in all PBMC fractions"), and they explicitly admit the ori signal in PBMCs might not be the vaccine at all ("the ori signal may reflect intracellular uptake of replication-origin–like DNA fragments rather than intact vaccine plasmid persistence")they only sanger sequenced the ori band. you cannot confirm proline substitutions on a gene that isn't there. how exactly is the plasmid producing spike protein if the spike gene (s1-s3) is missing?
>>16905131Authors detected plasmid DNA in skin tissue with spike gene sequences (S1-S3), ori and SV40 enhancer, confirmed by PCR and Sanger sequencing. It indicates intact/functional plasmid capable of transcription where spike persists in endothelium/nerves/macrophages. PBMC negatives for S1-S3/SV40 and ori caveat apply only to blood fractions, not tissue. Vaccine mRNA in exosomes was RT-PCR/Sanger-sequenced, matching BNT162b2 construct (including proline swaps), this systemic template drives translation of vaccine-specific spike. Protein sequencing unnecessary when templates prove it.
>>16905135they sequenced the ori, they didn't sequence the spike gene or the mrna, all they verified is "this guy has bacterial dna in his blood and spike protein in his skin"
>>16905140>they sequenced the ori, they didn't sequence the spike gene or the mrna, all they verified is "this guy has bacterial dna in his blood and spike protein in his skin"The study Sanger-sequenced PCR products from the skin biopsy plasmid DNA explicitly confirming spike gene sequences, ori and SV40 enhancer, hallmarks of the Pfizer vaccine plasmid, not random bacterial DNA. Verbatim: "spike gene sequences (S1–S3), ori1/ori2, and the SV40 enhancer, confirming durable retention of vaccine-derived DNA.... by..... Sanger sequencing." Exosomal vaccine mRNA was detected via specific RT-PCR (targeting BNT162b2 sequence). Spike protein in skin directly ties to these vaccine-unique templates. It is not unrelated debris.
>>16905145they used pcr for the spike gene. they used sanger for the ori. they NEVER sequenced the spike gene to confirm proline substitutions. if i test a blender full of food and find bread dna and cheese dna i cannot prove there is an intact sandwich down there.moreover the study proves the plasmid is fragmented. in the PBMCs (blood), they found the ori but not the spike gene. if the plasmid were intact, those two pieces would always be together.and finally, if the plasmid is functional, then where is the mrna? the study found zero mrna in the tissue.
>>16905152In skin (unlike fragmented ori-only in PBMCs), all elements co-occur, consistent with intact/functional plasmid from BNT162b2 (matched via GenBank-sequenced controls). Exosomal vaccine mRNA (clear S1-S3 amplification) circulates systemically for cellular uptake/translation. It explains spike in skin without local tissue mRNA. Your "blender" analogy fails: these are specific, co-detected vaccine blueprint parts, not random food DNA. You become boring and annoying, srsly. I am a man of great patience, but cmon xD
>>16905154they matched the bacterial backbone to the control. they never sequenced the spike gene to confirm the 2p mutations. they never verified the actual payload. concurrence doesn't mean intact. finding multiple fragments in the skin just means the tissue trapped more debris than the blood did.i appreciate the patience, but it's you inventing new biology (translation without mrna) to keep this thing alive.
>>16905160BTW, instead of making me repeat the same for a hundreth time, maybe try to rationally explain why people were force-injected with extremely dangerous modRNA/LNP and AVV gene therapy platforms at all, supposedly against a virus with official 0.001% mortality in 6-60 yo group xDPre-2020 knowledge highlighted significant risks in modRNA/LNP and AAV gene therapies, focusing on delivery challenges, immunogenicity, toxicity, and genomic integration.For modRNA/LNP: Early mRNA platforms suffered from inherent instability, rapid degradation by nucleases, and inefficient cellular uptake, limiting efficacy. High innate immunogenicity triggered potent inflammatory responses, potentially causing cytokine storms or autoimmunityhttps://pmc.ncbi.nlm.nih.gov/articles/PMC5906799LNPs, often cationic, posed cytotoxicity risks via membrane disruption and organ accumulation with animal studies showing repeat doses led to severe liver damage and halted human trials like Modernas 2016-2017 Crigler-Najjar program. Pseudouridine modifications reduced but didnt eliminate immune activation.https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2020.589959/fullFor AAV: Vectors elicited strong humoral and cellular immunity, neutralizing efficacy and preventing redosing. The tech caused hepatotoxicity, with elevated transaminases and potential liver failure observed in trials. insertional mutagenesis risked oncogenesis, as AAV integrates into host DNA at low rates but could disrupt tumor suppressorshttps://www.sciencedirect.com/science/article/abs/pii/S0273230022002197Preclinical data showed dorsal root ganglion neurotoxicity and complement activation leading to systemic inflammation.These experimental therapies were deemed high-risk without long-term safety data, warranting caution in human use, so how come, all of a sudden, they became "safe and effective" in 2020? xD
>>16905161two worlds: wealth transfer!like i can argue about sequencing until the sun explodes, but i'm not gonna defend the clown show.
*words
>>16905171It looks like a deliberate genocide to me. We live in era when elites agressively replace humans with using AI/data centers as well as advanced robotics/androisation, and constantly/increasingly whine about non-renewable resource depletion and overpopulation vastly exceeding the Earths biocapacity. It doesnt take a genius to connect dots, right? xD
>>16905175actually had a family member who sat on one of the state level advisory boards during the whole pandemic. if there was a grand conspiracy, it was strictly the biggest players (USA, China, etc). the middle-sized Euro nations, they weren't onboard. Klaus Schwab literally called the pandemic a litmus test for their new economic model. it would be crazy not to see the patterns, but i wouldn't mistake their incompetence and greed for a perfectly executed genocide, they aren't that smart.
>>16905177>Klaus Schwab literally called the pandemic a litmus test for their new economic model.He is right. Fiat must die after the 2020/2022 gene therapy poisoning and thats the goal.In accelerated depopulation with humans gradually replaced by data centers/AI, classic fiat currencies falter due to deflationary pressures, falling velocity (MV=PQ) and ineffective transmission via banks amid shrinking human activity and credit demand.CBDCs prove more rational because of following reasons:1) Programmability enables direct negative interest rates or demurrage (Gesell-inspired), bypassing the zero lower bound to combat hoarding and deflation which is impossible with physical cash.2) Precision control over money supply and velocity counters low Q and V by forcing circulation toward machine/AI-sustaining investments.3) Direct stimulus like programmable UBI or targeted transfers supports demand in a low-human-consumption economy, aligning with Keynesian/MMT tools without intermediaries.4) Near-zero transaction costs and instant machine-to-machine settlements enhance efficiency in an automated production system (Coasean logic).5) Maximized seigniorage via tracking reduces evasion, funding public infrastructure for data centers.6) Programmable CBDCs allow governments to attach conditions to digital money like stimulus payments or benefits that activate only after verified compliance (like vaccination records linked via digital ID). Non-compliant individuals could face restricted access, expiration or blocked funds7) CBDCs can enforce per-wallet limits on purchases of scarce non-renewables like rare earths, fossil fuels, and prioritize allocation to AI infrastructure over human consumption.8) Expiring balances or use-it-or-lose-it conditions prevent residual human wealth from being stockpiled, forcing circulation into AI-sustaining investments.If they replace fiat with CBDC, i will be 100% sure that depopulation was the goal.
>>16905180don't forget the universal id! the elites already have all the money, terminal goal of total stability requires the absolute elimination of risk, which is just another word for human agency.
>>16905160>they matched the bacterial backbone to the controlThats imprecise.The study detected plasmid backbone elements (specifically, the origin of replication regions ori1/ori2 and the SV40 enhancer/promoter) in a skin biopsy via PCR amplification, agarose gel electrophoresis and Sanger sequencing. These are standard components of the bacterial plasmid used in manufacturing the Pfizer-BioNTech vaccine (for amplifying the DNA template before mRNA transcription). The sequences matched known vaccine plasmid features which could be seen as matching to the control if interpreting the expected vaccine sequences as the control. However, theres no explicit control sample like a lab-standard plasmid or unexposed tissue mentioned for direct comparison, the authors rely on sequence confirmation against public vaccine data and the absence of nucleocapsid to attribute it to the vaccine.>they never sequenced the spike gene to confirm the 2p mutationsThis is true. The study performed PCR targeting three specific regions of the spike open reading frame (labeled S1-S3, likely amplicons covering parts of the gene) in the skin biopsy with Sanger sequencing confirming the presence of vaccine-derived spike DNA sequences. However, theres no mention of sequencing the full spike gene or specifically checking for the two proline (2P) substitutions (K986P and V987P), which are engineered stabilizing mutations in the vaccines spike sequence. The focus is on detecting spike-related sequences to confirm vaccine origin, not on verifying mutations.
>>16905191look, at this point, just wire them $5000 usd to finish the sequencing and let this thing be over.
>>16905160>they never verified the actual payloadThis is false. The "payload" refers to the spike-coding genetic material delivered by the vaccine. The study explicitly verified its presence through PCR and Sanger sequencing of spike gene regions (S1-S3) in the skin biopsy alongside detection of spike mRNA in circulating exosomes via RT-PCR and spike protein via ELISA and immunohistochemistry. These were cross-confirmed across independent labs, attributing them to the vaccine based on sequence matches and nucleocapsid negativity.>concurrence doesn't mean intactThis is true and aligns with the studys findings. The authors detected co-occurring plasmid elements (spike sequences, ori1/ori2, SV40 enhancer) but describe them as "plasmid DNA fragments" or "elements," not as intact, full-length plasmids. No whole-plasmid sequencing or assembly is reported, and the methods (targeted PCR for specific regions) would only confirm fragments, not integrity of the entire 7-10 kb plasmid
>>16905160>finding multiple fragments in the skin just means the tissue trapped more debris than the blood didThis is interpretive critique, not directly contradicted or supported by the study as a factual claim. The study found plasmid DNA fragments exclusively in skin biopsies with persistent spike protein in skin endothelial cells, macrophages, and nerve fibers across multiple biopsies. In contrast, blood/plasma/exosomes/PBMCs showed spike protein and spike mRNA (in exosomes) but no plasmid DNA. The authors interpret this as tissue-specific persistence potentially driving inflammation and dysregulation, not as inert debris.
>>16905193They did not do full-length spike gene sequencing to confirm the signature 2P mutations that distinguish the vaccine sequence from wild-type SARS-CoV-2 spike. They also didnt perform long-read or whole-plasmid sequencing to prove the bacterial backbone elements were part of one intact, replication-competent plasmid versus scattered fragments. Additional full/plasmid-level sequencing of the persisting material like long-read Nanopore or PacBio to assemble larger contigs, or deeper targeted NGS across the entire spike ORF could theoretically strengthen or refute the vaccine-origin claim by checking for those exact engineered mutations and assessing fragment integrity/assembly potential, indeed. The study is very useful, tho. It provides strong evidence of prolonged persistence of spike protein, mRNA, and plasmid DNA fragments in a single well-documented case, supported by multi-omic data, independent lab confirmations, and exclusion of SARS-CoV-2 infection. However lacking full-length spike sequencing (to confirm 2P mutations) and long-read/whole-plasmid analysis leaves open whether the DNA is intact, functional, or vaccine-specific versus fragmented/debris. These gaps weaken causal claims. My question is why nobody performs similar studies? There is no single study checking a large cohort of vaxxies in context of genomic instability. For a reason, i guess.
>>16905204Finally, spike proteins typical short half-life (hours-days, per general knowledge) indeed contradicts inert debris persisting 1,364+ days as the study challenges "rapid degradation" assumptions without directly stating half-life. ELISA/IHC detect epitopes on full/near-full protein, not MHC peptides. Latest protein detection is 1,364 days (skin IHC), but serology at 1,433 days shows elevated spike antibodies, implying ongoing stimulation/active production from persistent mRNA/DNA, per the studys hypothesis. This is extremely worrying.
>>16905204I was put at ease with the jabs in a general sense because they don't actually know what they are doing. List all types of RNA and all of their mechanisms of action and importantly what triggers them. Basically, the concern was if this was the final kill shot and it is merely a prototype thankfully. I wouldn't consume vaxaids milk or salad, but this type of bioengineering has no chance of wild type proliferation either.
>>16905263>I was put at ease with the jabs in a general sense because they don't actually know what they are doingmodRNA/LNP platforms carry inherent unpredictability due to: 1) systemic biodistribution of LNPs beyond the liver, 2) prolonged and unpredictable modRNA translation, and 3) potential for genomic integration via endogenous reverse transcriptase. Cancelled Moderna trials from 2017 highlighted severe inflammatory reactions, indicating immune system misdirection.Permanent health destruction could occur through autoimmunity: persistent foreign protein synthesis triggers cytotoxic T-cell attacks on transfected cells; sustained ER stress & apoptosis from excessive protein production, leading to tissue damage; epigenetic dysregulation and genomic instability from double-stranded RNA byproducts, interfering with non-coding RNA function; lipid nanoparticle toxicity, initiating chronic inflammatory pathways like NLRP3 inflammasome, even without RNA; disruption of alternative splicing and proteomic chaos from off-target protein expression etc etc.The systemic uncontrolled nature of the delivery creates multiple intersecting pathways for chronic degenerative and autoimmune disease with damage potentially accumulating silently over time.Those who injected this extremely dangerous thing into humans must have been fully aware of what they were doing. It was done intentionally to destroy health and fertility of hundreds millions of people from developed countries and radically reduce their life expectancy. This thing was also proven by multiple recent studies to be capable if inducing damage to reproductive organs, it destroys sperm quality/motility, depletes ovarian reserves, causes stillbirths, miscarriages, abortions, fetus defects etc. The question is if it is also capable to cause intergenerational damage. No studies checked it yet.
Pre-2020 mRNA research involved animal trials, but these revealed challenges like excessive inflammation and short follow-up times, limiting insights into chronic effectshttps://www.nature.com/articles/s41587-022-01294-2https://pmc.ncbi.nlm.nih.gov/articles/PMC9264994/For COVID-19 vaccines, trials were accelerated with overlapping animal/human phases, reducing longitudinal data. This gap is acknowledged in reviews, as animal models often show mild symptoms and fail to predict rare human AEs.https://pmc.ncbi.nlm.nih.gov/articles/PMC8537799/https://link.springer.com/article/10.15252/embr.202153751Animal biodistribution for Pfizer/Moderna LNPs often ended at 48 hours to weeks, potentially missing chronic accumulation or pathologies. Human studies later detected mRNA/spike up to months/years, suggesting longer persistence.https://pmc.ncbi.nlm.nih.gov/articles/PMC10812935/Rodent models differ from humans in LINE-1 regulation (expression patterns, epigenetic control), potentially underestimating reverse-transcription/integration risks for modRNA. https://pmc.ncbi.nlm.nih.gov/articles/PMC4457320/https://www.biorxiv.org/content/10.1101/2023.02.10.527906v1.full.pdfhttps://journals.asm.org/doi/10.1128/microbiolspec.mdna3-0061-2014https://www.sciencedirect.com/science/article/pii/S2451945619301412In vitro studies show LINE-1 can reverse-transcribe modRNA, but short-term rodent assays may miss germline/somatic integration. https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2020.00657/fullLNPs can cause repeated inflammation ( cytokine storms, oxidative stress), leading to potential cumulative damage in organs.https://pmc.ncbi.nlm.nih.gov/articles/PMC11024862https://www.sciencedirect.com/science/article/abs/pii/S016836592500879Xhttps://www.science.org/doi/10.1126/scitranslmed.adv2293https://www.preprints.org/manuscript/202501.1462https://pmc.ncbi.nlm.nih.gov/articles/PMC11510967
>>16905406Reviews note risks from long-term exposure, especially in repeated dosing.https://medium.com/microbial-instincts/concerns-of-lipid-nanoparticle-carrying-mrna-vaccine-into-the-brain-what-to-make-of-it-42b1a98dae27Case reports link mRNA vaccines to delayed/new-onset autoimmune issues (SLE, arthritis, myocarditis etc), potentially from persistent spike/mRNA or immune dysregulation. https://pmc.ncbi.nlm.nih.gov/articles/PMC12411051https://www.sciencedirect.com/science/article/pii/S240584402501864Xhttps://jamanetwork.com/journals/jamanetworkopen/fullarticle/2823018https://ard.bmj.com/content/83/6/687https://pmc.ncbi.nlm.nih.gov/articles/PMC9399140https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1549739/fullIntegration risks (via LINE-1) are plausible but hard to detect in short-term rodent models due to species differences and limited duration. https://pmc.ncbi.nlm.nih.gov/articles/PMC11169277https://pmc.ncbi.nlm.nih.gov/articles/PMC10091642Multi-generational studies are rare, masking potential inheritance. https://www.nature.com/articles/s42003-024-07444-3https://www.mdpi.com/2075-4655/8/1/1modRNA/LNP can synergistically amplify inflammation (via TLR activation, cytokine loops etc) and create self-sustaining responses. https://www.sciencedirect.com/science/article/pii/S1525001624006051https://www.nature.com/articles/s41541-023-00751-6https://pmc.ncbi.nlm.nih.gov/articles/PMC10618257https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202451008https://www.preprints.org/manuscript/202501.1462Reviews highlight adjuvant-like effects leading to autoimmunity. https://www.preprints.org/manuscript/202501.1462Most preclinical work is short-term/single-species, making long-term instability plausible but theoretical.https://pmc.ncbi.nlm.nih.gov/articles/PMC9264994https://www.frontierspartnerships.org/journals/british-journal-of-biomedical-science/articles/10.3389/bjbs.2025.14557/full
CANCERA 2024 MDPI review analyzes plausible links between SARS-CoV-2 mRNA vaccines (BNT162b2, mRNA-1273) and cancer promotion via non-genotoxic mechanisms like Spike-induced EMT, oncogenic pathway activation (ERK/MAPK, EGFR-AKT), TP53 inhibition, autophagy disruption, and inflammatory TME. It cites case reports of lymphomas, leukemias, sarcomas post-vaccination and a Seoul cohort study showing elevated HR for thyroid, gastric, colorectal, lung, breast, prostate cancers 1yr post-vax. https://www.mdpi.com/2072-6694/17/23/3867A 2024 Frontiers article highlights mRNA-LNP-induced immune suppression (tolerogenic IgG4 switch, T-cell anergy) disrupting cancer immunosurveillance, potentially increasing relapse risks. References correlations in studies and mouse models showing inherited immune alterations. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1336906/fullA 2025 preprint hypothesizes genotoxic risks from LNP-mRNA adducts, where reactive lipids covalently bind nucleotides, reducing translation and potentially mutating DNA via error-prone repair or ROS. Based on Modernas 2021 study showing temperature-dependent adduct formation, it links to carcinogenesis via genomic instability, akin to drug-induced toxicities like fialuridinehttps://www.preprints.org/manuscript/202509.0701/v1Another 2025 preprint details "turbo cancer" via insertion mutagenesis (mRNA reverse transcription/DNA integration, per Alden 2023 in vitro study), frameshifts producing aberrant proteins (Mulroney 2023 mass spec), somatic hypermutation overdrive, and immune suppression ( IgG4 shift, p53 inhibition)https://www.preprints.org/manuscript/202501.1462
>>16905414MORE CANCER2024 Cureus study: Analyzed Japanese data; excess age-adjusted mortality for all cancers and specific types (ovarian, leukemia, prostate, lip/oral/pharyngeal, pancreatic, breast) in 2022 after third mRNA dose rollout.https://www.cureus.com/articles/196275-increased-age-adjusted-cancer-mortality-after-the-third-mrna-lipid-nanoparticle-vaccine-dose-during-the-covid-19-pandemic-in-japan2025 Oncotarget review: Analyzed 69 pubs (66 case reports on 333 pts, 2 pop studies, 1 mil analysis); recurrent rapid progression, atypical histo; immunologic links to tumor escape.https://www.oncotarget.com/article/28824/text2025 Biomarker Res cohort: Seoul, 595k unvax vs 2.38M vax; HR up for thyroid (1.35), gastric (1.34), colorectal (1.28), lung (1.53), breast (1.20), prostate (1.69) cancers 1yr post-vax; varies by type/age/sex. https://link.springer.com/article/10.1186/s40364-025-00831-w2023 Cureus review: Multi-hit oncogenesis; vax induces lymphopenia, inflammation, ACE2 downreg, oncogenic activation, retroelement unsilencing; pro-tumor milieu in cancer pts.https://pmc.ncbi.nlm.nih.gov/articles/PMC107922662025 Cancers MDPI: Spike activates EMT/prolif paths (ERK/AKT); disrupts autophagy/immunosurv; IgG4 shift; 28+ case reports (lymphomas, leukemias, sarcomas). https://www.mdpi.com/2072-6694/17/23/3867
Of course all the vaxxed are going to die. Approximately everybody alive today will be dead in 100 years.As to whether a mass mortality event in the vaxxed is imminent, I would have to answer no.
AUTOIMMUNITY2024 PubMed Korean cohort: mRNA vax linked to 1.16-fold SLE risk; boosters up RA, AA, psoriasis. https://pubmed.ncbi.nlm.nih.gov/390391132023 ScienceDirect review: COVID-19 vax causes new-onset autoimmune glomerulonephritis, rheumatic diseases, hepatitis via mimicry, bystander, adjuvants. https://www.sciencedirect.com/science/article/abs/pii/S15689972230007452024 ARD BMJ: New AIIRD cases (arthritis, CTD, vasculitis) post-mRNA vax; flares 10-37%. https://ard.bmj.com/content/83/6/6872025 MDPI Vaccines: mRNA induces SLE, RA, T1D, autoimmune hepatitis, GBS via complex responses. https://www.mdpi.com/2076-393X/13/11/11122025 Frontiers: mRNA vax correlates with anti-Hsp autoantibodies in vaccinated, tied to autoimmunity. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1549739/full2023 PMC: Alopecia, psoriasis, vasculitis, sarcoidosis, IBD, RA, SLE, etc., post-mRNA but no sig increase for mosthttps://pmc.ncbi.nlm.nih.gov/articles/PMC101825982025 ScienceDirect: LNPs exacerbate inflammation, induce CRS in models, potential autoimmunity trigger. https://www.sciencedirect.com/science/article/pii/S2329050125001615
>>16905424MORE AUTOIMMUNITY2023 Taylor&Francis: mRNA vax triggers autoimmune in differentiated tissues via distribution. https://www.tandfonline.com/doi/full/10.1080/08916934.2023.22591232023 Nature EMM: mRNA-LNP causes autoimmunity via mRNA autoantigen/TLR7, LNP adjuvant, enhanced immune.https://www.nature.com/articles/s12276-023-01086-x2024 Frontiers: Frameshifts produce aberrant proteins, potential autoimmune contribution.https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1336906/full2022 PLOS: Pre-exposure mRNA-LNP inhibits adaptive immunity, alters innate fitness, risk for autoimmunity. https://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.10108302022 PMC: Innate activation by mRNA-LNP may lead to autoimmunity in susceptible. https://pmc.ncbi.nlm.nih.gov/articles/PMC96419822024 Springer: Boosters impair response, up IgG4, cause autoimmune diseases. https://link.springer.com/article/10.1007/s10238-023-01264-12024 Preprints: mRNA links to autoimmune hepatitis, CTD via PAMPs, TLR7/8/9, self-reactive B cells. https://www.preprints.org/manuscript/202411.0008/v12021 iScience: LNPs induce robust inflammation, neutrophil influx, cytokines, potential autoimmunity driverhttps://www.cell.com/iscience/fulltext/S2589-0042(21)01450-4
CARDIOVASCULAR2022 Cell: mRNA-LNP biodist to heart; links to myocarditis, MI, thrombosis, Bell's, GBS.https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(22)00103-42021 PMC: LNP in mRNA vax may cause myocarditis via autoimmune; cites NVX-CoV2373 case. https://pmc.ncbi.nlm.nih.gov/articles/PMC86774262025 Preprints: mRNA-LNP rises myocarditis (1152x), thrombosis (455x), MI (218x) vs flu vax.https://www.preprints.org/manuscript/202501.14622025 Stanford: mRNA vax inflames heart via immune response in young males. https://med.stanford.edu/news/all-news/2025/12/myocarditis-vaccine-covid.html2024 ACS Nano: LNP-mRNA in heart tissue up to 30d post-vax; autopsy findingshttps://pubs.acs.org/doi/10.1021/acsnano.4c116522021 Nat Rev Mater: LNP induces inflammation, injuries; potential heart damage.https://www.nature.com/articles/s41578-021-00358-02023 Heritage: LNP toxicity, cardiac accumulation -> myocarditis, pericarditishttps://www.heritage.org/public-health/commentary/should-lipid-nanoparticles-used-mrna-covid-injections-have-received-more2023 PMC review: CV AEs post-mRNA vax; thrombosis (13,936 cases), stroke (758), PE (301); thrombosis common in BNT162b2, stroke in mRNA-1273. https://pmc.ncbi.nlm.nih.gov/articles/PMC100224212022 Trends Mol Med: mRNA AEs incl CVST, PE, stroke, TTS; via proinflammatory LNP/mRNA, Spike effects. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(22)00103-42024 ECI: Endotheliopathy, thrombosis post-mRNA; via GL degradation, oxidative stress, NETosis. https://onlinelibrary.wiley.com/doi/10.1111/eci.142962022 MDPI: Safety signal for CVT post-mRNA; disproportionality in WHO db. https://www.mdpi.com/2076-393X/10/5/799?fbclid=IwAR3bDJxBhU-i8eozotRdk9EpWqOAdz4nqHX4h4cgu9U7vNZyWoUqWTLna1w
FERTILITY2023 MDPI rat study: mRNA/inactivated vax reduced primordial/primary/secondary follicles, AMH levels, increased atretic follicles/apoptosis; stronger w/ mRNA; suggests ovarian reserve damage. https://www.mdpi.com/2076-393X/13/4/3452022 PMC: Reanalysis of Shimabukuro data showed 81.9% miscarriage rate for 1st/2nd trimester vax; criticizes original 12.6% as misleading due to denominator issueshttps://pmc.ncbi.nlm.nih.gov/articles/PMC88946882021 MDPI review: LNPs biodistribute to ovaries; may cause AVR, fetal multi-organ changes; questions mRNA safety in pregnancy re stillbirth/miscarriagehttps://www.mdpi.com/2076-393X/9/11/13512021 OAPub: Predicts mRNA vax increases genome alteration, cancer, organ failure; booster in pregnancy disrupts fetal brain protein synthesis, potential damage. https://openaccesspub.org/international-journal-of-coronaviruses/article/17842025 medRxiv: Analyzed fetal losses post-mRNA vax; suggests higher-than-expected in early pregnancy vs flu vaxhttps://www.medrxiv.org/content/10.1101/2025.06.18.25329352v1.full-text2022 Andrology: Gat et al, 37 semen donors; post-BNT162b2 vax (T2: 75-150d), sperm conc 15.4% (67.5 to 57.5M/ml), TMSC 22.1% (140.4 to 119.4M); https://www.jelsciences.com/articles/jbres1648.php2024 Front Immunol: 302 men; post-2 doses inactivated vax, total motility (58.62% to 46.90%); https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1321406/full2021 IJVTPR review: Seneff/Nigh; mRNA/LNP may reach germ cells, incorporate into DNA via RT; prion-like seq in Spike risks neurodegeneration/fertility; biodist to testes possible. https://www.dpbh.nv.gov/siteassets/boards/boh/meetings/2021/SENEFF_1.PDF
RENAL2025 ScienceDirect: Single-center, 6 pts de novo/relapsing glomerular diseases post-mRNA vax, biopsy-confirmedhttps://www.sciencedirect.com/science/article/pii/S00029629250000112022 PMC review: 130 cases renal AEs post-vax; MCD (52), IgAN (48), ANCA (15), etc. https://pmc.ncbi.nlm.nih.gov/articles/PMC96961892025 PMC: Vax assoc w/ higher AKI risk, dialysis; cumulative renal dysfunction inc.https://pmc.ncbi.nlm.nih.gov/articles/PMC125953412023 Frontiers: 27 pts AKD post-vax (mostly mRNA); GN (16), CKD deterioration (11). https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1189243/full2025 ResearchGate: Single-center, unexpected renal SEs post-mRNA; similar to above. https://www.researchgate.net/publication/387804132_Unexpected_renal_side_effects_of_mRNA_COVID-19_vaccines_a_single-center_experience_and_short_review2023 ESM: mRNA vax AEs incl AKI, CKD; DNA contam risks.https://esmed.org/impacts-of-covid-19-mrna-vaccination-and-infection2025 Surabaya MJ: mRNA vax correlates w/ renal disease inc (AKI forms).https://surabayamedicaljournal.or.id/indonesia/article/view/162023 ScienceOpen review: IgAN/other kidney diseases triggered by mRNA vaxhttps://www.scienceopen.com/document_file/5da1b51c-f96f-4a18-a548-3aabe000fb77/PubMedCentral/5da1b51c-f96f-4a18-a548-3aabe000fb77.pdf2021 Fierce Pharma: EMA probes mRNA link to nephrotic syndrome, glomerulonephritishttps://www.fiercepharma.com/pharma/europe-probing-link-between-pfizer-biontech-moderna-covid-vaccines-and-skin-condition-22024 MDPI: mRNA-LNP induces inflammation; potential renal contrib via complementhttps://www.mdpi.com/1422-0067/25/7/3595
NEURO2022 PMC: Spike/LNP proinflammatory; AEs incl Bell's palsy, CVST, GBS, myelitis. https://pmc.ncbi.nlm.nih.gov/articles/PMC90213672022 MDPI: Neuro AEs post-mRNA: seizures, orofacial, CNS eventshttps://www.mdpi.com/2305-6320/9/8/432024 PMC: Vax links to seizures, strokes, ADEM, MS, TM, ON, BP, GBS. https://pmc.ncbi.nlm.nih.gov/articles/PMC122876432021 iScience: LNPs highly inflammatory; potential side effects inc neurohttps://www.sciencedirect.com/science/article/pii/S25890042210145042024 ECI: Spike/LNP pathophys; neuro disorders via infl/endotheliopathyhttps://onlinelibrary.wiley.com/doi/10.1111/eci.142962024 Front Immunol: Infl responses affect brain; neuro SAEshttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1336906/full2022 Ann Neurol: Higher GBS, CVT, seizure post-Janssen; but mRNA notedhttps://www.researchgate.net/publication/358962431_Neurological_Events_Reported_after_COVID-19_Vaccines_An_Analysis_of_Vaccine_Adverse_Event_Reporting_System2021 iScience: LNPs infl in mice; possible CNS access, side effects.https://www.cell.com/iscience/fulltext/S2589-0042(21)01450-42023 Vaccines: Neuro disorders post-vax: vascular, immune, functional.https://pmc.ncbi.nlm.nih.gov/articles/PMC103026652024 IJMS: Lipids induce complement/cytokines; infl AEs inc neurohttps://www.mdpi.com/1422-0067/25/7/35952025 IJIRMS: mRNA links to neuropsychiatric; brain dysfunction.https://thevaccinereaction.org/2025/09/covid-19-shots-associated-with-neuropsychiatric-disorders2024 Front Pharmacol: Immune neuro events: CVST, BP, HZ, myelitis, ADEM, polyneuropathyhttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1376474/full2022 J Neuroimmunol: Systematic review immune neuro AEs: GBS, TM, ADEM, etchttps://www.researchgate.net/publication/357162764_Neurological_Immune-Related_Adverse_Events_After_COVID-19_Vaccination_A_Systematic_Review
LIVER2023 PMC: Immune-mediated liver injury post-COVID vax; mRNA (BNT162b2, mRNA-1273) induces AIH-like via immune paths; LNPs link to allergies/immune mediation. https://pmc.ncbi.nlm.nih.gov/articles/PMC100750552022 PMC: 87 cases liver injury post-vax (51 Pfizer, 16 Moderna); median 15d onset; immune-mediated hepatitis; https://pmc.ncbi.nlm.nih.gov/articles/PMC93483262022 PMC review: 138 AIH, 52 PVT, 26 raised enzymes, 21 liver injury post-vax incl mRNA; new-onset/relapse. https://pmc.ncbi.nlm.nih.gov/articles/PMC95595502022 PMC: ALI mimicking AIH post-BNT162b2; hepatocellular injury, autoantibodies, IgG up; https://pmc.ncbi.nlm.nih.gov/articles/PMC93767382024 ScienceDirect: Off-target liver expr in mRNA-LNP vax; potential side effects from hepatic antigen expr. https://www.sciencedirect.com/science/article/pii/S23290501240021832023 Nature EMM: mRNA-LNP autoimmunity via TLR7, adjuvant, enhanced immune; incl liver effects. https://www.nature.com/articles/s12276-023-01086-x2025 Preprints: mRNA-LNP biodist to liver; assoc w/ toxicity, inflammation. https://www.preprints.org/manuscript/202501.14622026 RSC: LNP hepatotoxicity; 50-80% dose to hepatocytes, complement/cytokine trigger.https://pubs.rsc.org/en/content/articlehtml/2026/pm/d5pm00159e
PSYCH/MENTAL2022 PMC review: 14 cases psych AEs post-COVID vax (mRNA/vector); altered states, psychosis, mania, depressionhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90064212024 Frontiers sys rev: 24 new-onset psychosis post-vax; 33% mRNA BNT162b2https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1360338/full2024 PMC Seoul cohort: Vax inc risks depression (HR 1.15), anxiety (1.24), dissociative/stress/somatoform (1.42), sleep disorders (1.13).https://pmc.ncbi.nlm.nih.gov/articles/PMC115411972025 medRxiv survey: 12.5% post-mRNA vax mental symp (PCVS); anxiety, depression, cognitive issues. https://www.medrxiv.org/content/10.1101/2025.04.02.25325121v1.full-text2024 OPHRP sys rev: Psych AEs post-vax Korea; sleep disturb/anxiety most; BNT162b2 focushttps://ophrp.org/journal/view.php?number=7672023 Academia case: 50yo F severe psych symp post-Moderna; hosp, St. John's wort interaction.https://www.academia.edu/106341896/Case_Report_Psychiatric_Symptoms_Associated_with_the_Moderna_Covid_19_mRNA_Vaccine2023 ResearchGate case: Sudden psych symp post-Moderna mRNA;https://www.researchgate.net/publication/369990402_Case_Report_Psychiatric_Symptoms_Associated_With_the_Moderna_mRNA_COVID-19_Vaccine_Administration_and_Their_Resolution2024 Frontiers cases: 3 pts anxiety post-BNT162b2; inc risks depression/anxiety noted. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1514428/full2024 Debuglies: mRNA vax induce anxiety etc via spike; pop study.https://debuglies.com/2024/10/07/the-complex-interplay-between-covid-19-vaccination-and-mental-health-a-detailed-analysis-of-psychiatric-adverse-events-in-a-population-based-study2022 MDPI review: Psych conds post-mRNA; NMS, autoimmune psychosishttps://www.mdpi.com/2075-4418/12/7/15552023 PMC cases: 2 psych pts acute agitation/psychosis post-Moderna; memantine resolvedhttps://pmc.ncbi.nlm.nih.gov/articles/PMC9995323
>>16905394All true, but I was getting at something different. Take reproduction time in relation to the 5' cap. By itself is a collection of regulated processes which have parameters but which not any have been studied to account for population variation. The general safety is thought to be confirmed by monitoring serum levels. Fraud and other such things aside, a population study doesn't have sufficient justification to hold a safety claim. The actual parameters of regulation are unknown as well as their determiners. It is like having a software patch on some cross-platform app and some specific feature inside an unpopular cell phone doesn't interact correctly and the app doesn't open. But you studied the profile of successful patching across the entire population of computing devices and found 99% success rate. Completely irrelevant for the degenerate case and it could be the case that it directly causes the crash. Here is an example study on cells intentionally removing or preserving said caps.https://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30651-2Such things are taken in a modal form1. x can happen minimally under lab conditions2. what other conditions does it occur in 3. specific mechanism to activate conditionThese questions are about specifically about the theory of regulating x. This is all in cutting edge of research stage. In a similar way that JWST opened up blind spots in physics, future practices are guaranteed to condemn the mass experimentation done by the juicers.This general profile of things I looked at back during covid times. I am keenly sensitive to government controlled kill switches. LLMs make this process significantly easier, but I am not going to blow this thread up with studies I haven't looked at. At any given point in the theory you are probably 3 steps away from completely unanswered questions.
RESP2022 iScience: LNP in mRNA vax highly inflammatory; intranasal delivery causes lung inflammation, neutrophil influx, cytokine storm, 80% mortality in mice. https://www.sciencedirect.com/science/article/pii/S25890042210145042022 Mol Ther: Pro-inflammatory LNPs; intranasal induces IL-1β/IL-6/CCL3/4, massive lung infl, high mortality dose-dep.https://pmc.ncbi.nlm.nih.gov/articles/PMC90476132022 PMC: Autopsy ARDS post-mRNA-1273; vaccine-induced lung distress, DAD, edemahttps://pmc.ncbi.nlm.nih.gov/articles/PMC90547062023 Clin Case Rep: mRNA vax-induced severe pneumonitis; high IgE, cytokines (TNFα/IL-6/IL-8), resp failure.https://pmc.ncbi.nlm.nih.gov/articles/PMC123711232021 Intern Med: mRNA vax pneumonitis case; type IV hypersens, intradermal test poshttps://www.researchgate.net/publication/355649903_COVID-19_mRNA_Vaccine-induced_Pneumonitis_A_Case_Report2024 Vaccines: LNPs toxicity; ionizable lipids trigger TLR/infl resp, pulm embolism AE.https://www.mdpi.com/2076-393X/12/10/11482024 ACS Nano: Larger LNPs cause acute tox, embolism in mice post-IV. https://pubs.acs.org/doi/10.1021/acsnano.4c186362024 Nat Comm: Pos charged LNPs elevate WBC/CRP/cytokines, potential pulm tox in mice. https://www.nature.com/articles/s41467-024-53914-x2022 Trends Mol Med: LNPs proinflammatory; AEs incl pulm embolism, resp issueshttps://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(22)00103-4
VISUAL2022 PMC sys rev: Ocular AEs post-mRNA: facial palsy, abducens palsy, macular neuroretinopathy, central serous retinopathy, thrombosis, uveitis, white dot syndrome, VKH reactivation. https://pmc.ncbi.nlm.nih.gov/articles/PMC84775882024 EyeWiki: Anterior uveitis, scleritis, episcleritis, white dot syndrome, VKH, panuveitis, choroiditis, central serous chorioretinopathy, orbital infl, dacryoadenitis, corneal graft reject, optic neuritis, AAION, NA-AION post-mRNAhttps://eyewiki.org/Ocular_Adverse_Reactions_after_Receiving_COVID-19_Vaccine2022 PMC sys rev: 74 ocular AEs: facial/abducens palsy, corneal reject, macular neuroretinopathy, uveitis, vein thrombosis, central serous chorioretinopathy, VKH, Graves orbitopathy post-vax incl mRNAhttps://www.aao.org/education/editors-choice/rare-ocular-side-effects-have-been-noted-after-cov2023 ESM case: Acute anterior uveitis post-BNT162b2 mRNA; most common ocular AE.https://esmed.org/acute-anterior-uveitis-post-covid-19-mrna-vaccination2024 Vaccines MDPI rev: Retinal vascular occlusion (RVO/RAO) post-mRNA; mechanisms incl immune thrombotic thrombocytopenia, endothelial dysfunction, inflammationhttps://www.mdpi.com/2076-393X/13/7/7332023 AES: Optic neuritis post-mRNA; 18 cases Japan, mostly Pfizerhttps://aes.amegroups.org/article/view/7104/html2021 PMC: AAION & AZOOR post-mRNA vax; autoimmune linkhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83587692024 J Pers Med rev: Corneal reject (73% Pfizer, 26% Moderna), uveitis (1094 cases VAERS) post-mRNA. https://www.mdpi.com/2075-4426/14/8/7802022 medRxiv: Glaucoma post-mRNA; 161 cases VAERS, crude rate 0.09-0.07/mil doseshttps://www.medrxiv.org/content/10.1101/2022.06.13.22276314v1.full-text2025 Vaccines sys rev: Ocular on eyelid, cornea/surface, retina, uvea, nerve, vessel post-vax incl mRNA. https://www.researchgate.net/publication/356675472_Ocular_Manifestations_after_Receiving_COVID-19_Vaccine_A_Systematic_Review
>>16905641MORE VISUAL2025 PMC sys rev: Uveitis most common; anterior scleritis, macular neuroretinopathy, panuveitis, PAMM, subretinal fluid post-mRNAhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125382342024 JCEM: TED risk up post-vax, esp <50yo. https://academic.oup.com/jcem/article/109/2/516/72504762024 Preprints: Ocular AEs incl macular bleed, visual loss, conjunctivitis, episcleritis, ocular/orbital infl, retinopathy, uveo-retinitis post-mRNA-LNPhttps://www.preprints.org/manuscript/202411.1837/v3
