>>16926536
SSRIs/SNRIs also hit 5-ht2a receptors retardo
Why is psychiatry such easy bait for psych patients to think they're the experts, I feel bad for the shrinks

>>16926553
>Why is psychiatry such easy bait for psych patients to think they're the experts,
Because shrinks don't take the drugs they prescribe, ssris do blunt your emotions, that's by design, you can't feel negative feelings if you can't feel anything at all

They definitely can be. Also the most effective treatment for curing addiction, particularly alcoholism. Interestingly, they don't really work for people on antidepressants.

>>16926560
First time in /sci/ and happen to find this thread. As a patient taking SSRIs can confirm that these mofos blunt your emotions. But i also take them in tandem with other meds, so take it with a grain of salt

File: SSRI-somatodendritic-area.png (204 KB, 1003x613)

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>>16926536
>(SSRIs do this)
That's not what they do. They force serotonin to stay in synapses longer, which is initially highly stimulatory, but subsequently does 2 main things after a few weeks:

1) Downregulates/desensitizes 5-HT receptors in general
2) Upregulates enzymes for neurotransmitter breakdown in general

When you pay attention to how this "helps" anyone, it's almost exclusively seen as good in those individuals suffering from emotional outbursts. SSRIs stop them from needing to cry or scream or otherwise cause undue emotional damage in their everyday interactions.

As far as 5-HT1 goes, that is simply focused on more because it is a better long-term target. It takes weeks or months to cause serotonin neuron desensitization. 5-HT2 has a much more rapid period of adjustment, so desensitization happens quickly and rebounds quickly. However, SSRIs have effects on both.

Serotonergics work well in low doses

>>16926536
most 5ht receptors are located in the gi tract and also the mouse tail suspension test is dubious at best. ssri efficacy is modest and causes wiener disease