What's the evolutionary drive for 5-HT2A receptors? People can take antagonists with seemingly no major ill effects.
>>16977393I was just thinking that someone ought to sort of update the terrence mckenna sort of anthropological model for the manifesting of psychedelic awareness in the book the fruit of the gods, the claim that homo sapiens ate mushrooms and that was part of the transition between arboreal tree dwelling and more of plains dwelling life style or something like that, although that model is pretty old at this point but fitting that to accord with the more recent surge of psychedelic research over the last few years would probably be half the things of writing such a tome
>>16977393>antagonists>posts an agonist
>>16977393>more potent than LSD>easy as piss to grow>can dry and smoke the leaves or just chew them fresh without swallowing(mucosal absorption)>comparative intensity to dmt>works with kappa opioid receptors instead of serotonin or cannabinoid
>>16978178Forgot pic, used to be available at gas stations and head shops around the country until too many retards got told its like weed before getting blasted into another dimension
>>16978178>>16978180>more potent than LSDNot even close. Salvia lasts for 10-20 min, then just feels like a mild weed high for a couple hours. At its peak, it's similar to LSD, but nowhere near as intense. Do they still sell it in shops? It's been a while since I've seen any.
>>16977393Okay i'm going to give you a real answer to help you understand this.the brain is made up of different regions, which are populations of neurons that all work together to do some specific job or general function. Lets take something like picking out important information in a scene, that's handled by your visual processing network. Sometimes the network wants to gather information from a distant place in the brain like the hippocampus, the way it does this is by *growing a nerve projection* to the distant target, and then exchanging chemical messengers. The neurotransmitters are sent to very specific placesThere are some very special places in the brain where the neurotransmitters sent directly correspond to sensory information. If drugs fuck with neurotransmitters here, the organism hallucinates. Its not evolved away because this specific sub-type of serotonin receptor probably doesn't encounter massive doses of a special chemical that fucks with it on a regular basis. Otherwise it would just not respond, same as toxin immunity works for other creatures that habitually eat something that would mess up the systems in their close relatives. They acquire a change in their receptors such that the toxin no longer works. But they only get that by exposure to the toxin over and over again.Humans are not exposed to psychedelic mushrooms on a long enough time to develop an evolutionary response like a resistance via altered receptors. There is evidence however, of human populations developing genetic resistance to alcohol for instance. We just haven't consumed psychedelic mushrooms for thousands of years like people are saying otherwise there actually would be mutations
>>16978180>>16978199with LSD, noticable activity starts at maybe 50μgSalvinorin is more like 200μgfor effects, yes its short acting, but you can very easily get a breakthrough experience that throws you into a completly different world and the 5minutes you spend there can feel like you lived a whole lifetime.LSD can do that, but you need pretty ridiculous doses that not many take.>>16978203tryptamine derived psychedelics aren't toxic (many dont even have an established LD50 and not for lack of trying) and DMT is even an endogenous neurotransmitter.we clearly react to these substances, because they play an important role in our cognitive function."drugs fuck with neurotransmitters" is an incredible ignorant and unsatisfactory explanation of their effects.
