New research out of Qingdao University in China is claiming that inhibiting warmth-sensitive Ca2+-permeable transient receptor potential vanilloid-3 (TRPV3) channels treats androgenic alopecia and that a chemical found in various mint plants does that...>https://www.sciencedirect.com/science/article/abs/pii/S0014299925000172>European Journal of Pharmacology>In Press, Journal Pre-Proof>Natural phenylethanoid glycoside forsythoside A alleviates androgenetic alopecia by selectively inhibiting TRPV3 channels in mice>In whole-cell patch clamp recordings, forsythoside A selectively inhibits macroscopic TRPV3 currents in a concentration-dependent manner with an IC50 value of 40.1 ± 4.8 μM. At the single-channel level, forsythoside A also reduces the channel open probability and open frequency without significantly altering the channel unitary conductance. Molecular docking combined with site-directed mutagenesis reveals two residues T636 and T665 critical for forsythoside A-mediated inhibition of TRPV3. Taken together, our findings demonstrate that TRPV3 inhibition is an important a mechanism by which natural forsythoside A ameliorates DHT-induced hair regrowth. Topical TRPV3 inhibitors may hold promise as a new therapeutic approach for treating androgenetic alopecia.>https://en.wikipedia.org/wiki/Forsythoside_B
>>75731046Saving this one
>>75731046Who cares, finasteride/dutasteride already solved hair loss
>>75731097I got fin too and my husband can fist me just as well as before I was put on dialysis!
>>75731148Everyone hating on the standard of care therapy like the FDA is some outdated boomer bureaucrats or something.
>>75731154Outdated corrupt satanic boomer bureaucrats.
Solves androgenic alopecia in mice that never have any androgenic alopecia. Wtf is that study about?
