What about a sitcom that initially seems like one of those '90s family comedies where the husband nags his wife repeatedly, but then, midway through the series, she asks for a divorce and the show takes a different direction, showing him becoming increasingly miserable?
You pretty much described pic related.
>>217036898>The series follows the dysfunctional Malloy family of Los Angeles, California: deadbeat father Jack (Geoff Pierson); toxic and narcissistic mother Jennifer (Stephanie Hodge); underachieving and seemingly dim-witted eldest son Ryan (Kevin Connolly); daughter Tiffany (Nikki Cox), academically gifted but rarely taken seriously because she looks like a model; and "forgotten" son Ross (Justin Berfield). In the first two seasons, storylines featured Jennie's pill-popping mother Maureen Slattery (Joyce Van Patten). In addition to other postmodern literary devices, the show and its characters regularly broke the fourth wall and mocked 1980s and 1990s American culture.>The series was initially written as a starring vehicle for Hodge, whose character Jennifer was the focus of the first few episodes. However, the series soon turned its focus to Jack Malloy, a schizophrenic, alcoholic, and lazy husband who was kicked out of the house in the pilot episode and, in a surrealistic mockery of both ALF and The Muppets, was living in an apartment with his imaginary friend: a foul mouthed, misanthropic, and sarcastic toy rabbit named Mr. Floppy (voiced by Bobcat Goldthwait). By the show's third season, Tiffany Malloy had become the breakout character, and Cox became the de facto co-star of the show along with Pierson. Stories began focusing more on Tiffany and Ryan's escapades at high school, and later at community college.Not very similar to what I was thinking