Progesterone is very annoying to use because there are no good routes of administration that are both long lasting and efficient. Unlike estradiol, progesterone lack -OH groups so it cannot be esterified.Progesterone has two =O moieties though, that are interesting, in the way that they can be modified into ethers, oximes or enol esters.I want to focus on the last of the three.The C3 end of progesterone is apparently very important for its progestogenic activity so it's better if we modify the other site, C20.Enter progesterone C20 enol decanoate. I think this molecule is promising for a long-lasting, oil-soluble, progesterone depot injection. First, the decanoate chain makes it very highly liposoluble, which avoids Progesterone's low solubility problem. Second, the depot effect created by a long lipophylic ester chain makes cling tightly to the oil depot, making it diffuse to the rest of the body slowly, like estradiol/testosterone enanthate and undecylate/undecanoate. Third, once the molecule escapes the oil depot and enters the bloodstream, it is (should) rapidly hydrolyzed to Progesterone. Yes, bioidentical progesterone, not any progestin derivative. This allows it to be a systemic source of progresterone, allowing for not only nuclear progesterone receptors to be bound but also membrane progesterone receptors, the later less likely to be targets of other progestins.This is where I need your help. The synthesis of progesterone C20 enol decanoate is probably quite easy, basically needing Progesterone and the fatty acid, i.e. decanoic acid, and the extra reagents to enolize the C20 site into a enol esterLab rats, chemists, hobby chemists, lab technicians, please respond and help develop this, which I think could be very useful. The answer to finally having a estradiol/progesterone combo injection or a long-lasting progesterone injectionj could be closer than we imagine.
Regarding literature, I haven't found basically anything regarding C20 enol esters of progesterone, but I do have found a C3 enol ester which I will link here https://en.wikipedia.org/wiki/Progesterone_3-acetyl_enol_etherThe reagents are progesterone of course, decanoyl chloride likely, THF as solvent, LiHMDS to form the progesterone lithium enolate, and DMPU to reduce chances of C-acylation and promote O-acylation.
Not a social contagion BTW
>>44449063oh and pic is from 2015 anime expo i believe?
>>44449063Casey Mongillo fascinates me so much because I'm pretty sure most people think think that they're afab non-binary, when they're actually a 38 year old amab non-binary who used to present as a trans woman.Like they basically hit that peak transfem passing to a point where they were able to switch to identifying as non-binary and legit most people just think that they're a transmasc eboi.
>>44447352the world is fucking ending who gives a shit tbhon
>>44447856>2018it was renamed from Gender Identity Disorder in 2013 as understanding of the condition advanced
>>44448622low T?
QOTT: What do you think happened to United Pharmacies US and United Pharmacies UK?• Help, advice, guidance on meds and dosages• HRT related medical experiences and research• Availability and pricing of medications• Rational and scientific discussion▶ FAQ: https://pghrt.diy/▶ Info Directory: https://diyhrt.info/▶ MTF Vendor index: https://valerie.vg (Formerly https://diyhrt.market/)▶ Articles/literature: https://transfemscience.org/▶ Estradiol simulator: https://estrannai.se/▶ TransDIY: https://www.reddit.com/r/transDIY▶HRTGen Template (use for new posts) https://rentry.co/hrtgtemp▷ Pill ID: https://www.drugs.com/imprints.phpComment too long. Click here to view the full text.
>>44445862whats happening in europewho is slurping all the estradiol
>>44446526avoid wheat and rice based foods, dairy and seed oils
Had a blood test done 1.5 years ago and e was 113pg/ml, so went from 75μg patch to 100μg but still feel it's kind of low. In a position now to up to 150μg from patches, anyone else had experience doing something like this? And if so what signs would you look for that the dose is right/wrong for you? (I should note T has been pretty much suppressed just from mono since 75μg patches)
>>44448881Probably someone like this but pink.
whats the best supplier if im in australia? just realised how much im getting cucked pricewise with a legal prescription (not to mention how bad using only pills is). would appreciate any advice :)
Summer fun Editionprevious: >>44206196Goal of the thread: Go out for a walk, or try to get any other form of small exercise (walking stairs for 5 mins for example)Daily goals can be repeated. Remember to keep score, it can only go up!>What is this thread for?Getting better is hard, and sucks. A lot. It does not get easier doing it alone.Share resources and experiences with combating depression, anxiety, personal issues, achieving or maintaining a healthy weight, etc.>Why is this thread /lgbt/?Struggles with mental and physical health are an indisputable part of /lgbt/ life, be it from dysphoria, social pressure, heartbreak, or just unfortunate lifestyle choices.>Notes to consider:Please be civil. Shame is your greatest enemy in fighting urges of self abuse (be it sh, drugs, or just self deprecation). Relapsing into bad and unhealthy habits is to be expected, the goal is to increase the average amount of time it takes between relapses. Any improvement is a victory no matter how small. Your worth and right to get better are non-negotiable. And most importantly:WE ARE NOT THERAPISTS, WE DON'T REPLACE MEDICATION>Note on adviceComment too long. Click here to view the full text.
>>44447087baka
>>44446909hi
>>44447087This looks like fun.
Good night
>>44435604>Thank you, bun..Catching up with a few of your posts right nowIt's all well and good.Thank you for the deligence and patience with me.>There was a lot going on in your life with no time to process and pressure from your education only confounding the matter,I wanted to take a gap year at first but decided on doing an IT certificate just to be productive.Everything spiraled from there I think.>you must have been overwhelmed as hell, and had nobody to lean onI was incredibly overwhelmed, everything day was a rush to get anything done.I did try to lean on my mother a bit, but some things can't be helped.I made two friends during my last year, and they don't reach out first due to how busy life is.I think I may be very isolated in general.Comment too long. Click here to view the full text.
Anyone have experience having a piercing while tucking? I was considering a reverse PA and a deep dydoe on both sides of the reverse PA, but I’m not sure how safe that would be.
idk, personally I'd be worried about getting an infection or irritating it
>>44450159What about once it’s healed?
>i want to have hot t4t sex with hazel
>>44448971What's with all the hazelfucker shitposting this weekend?
>>44448971she's so hot
>>44448971FFS will save her
man, i didn't ask to be born a fucking weapon...
>>44449792women are way more evil than men aremen are angels compared with womenI just want women to suffer and experience a fraction of the pain that they have caused me. If I ran America everyone would quit their jobs and start torturing women until we have killed every last demon dead for good.
>>44449830average dairy enjoyer
>>44449830Be honest, are you a pooner?
>>44449833kill all womentorture them slowlymake them bleed everywhere
>vegan>amab tranny rapestick haver>CNC enjoyer>unfuckable virginIt's never been more confusingly but definitely over
i am a cis man on hrt
>>44440620what senolytic and peptides do you use?also where did u get the senolytics
>>444489780s-01 (microneedle) and quercetin and fisetin (I don’t think I need Dasatinib and worry it could make my heart act funny when I’m a runner but in the future I may get occasional pulses). Then micro needled copper peptides, matrikines resevatrol all Korean brands and maelove glow vitamin c serum.Also pioglitazone.Cardio is important for triggering cell repair factors
>>44448637Oh, I mean, I guess that would make sense.Does it even feel good?
>>44449316How should I know. Ask one of the somehow multiple she/her srs femboys in this gen. They all seem to get the PPT method which is more natural and modern than older methods and avoids most of their downsides. Idk if being outside establishment trans means more openness to better but not traditional procedures.
>>44447399anon you're responding to>>44448637 is correct. I did say here >>44410786 that I'm going for it for sexual reasons.>>44449316>Does it even feel good?I will know in February at the earliest, assuming all goes well. That is November the surgery and 3-4 months recovery before I can actually use it.>>44449365>somehow multiple she/her srs femboys in this gennta but there are zero in this gen. I'm the one who will be (though still doubt on the she/her part).>They all seem to get the PPT methodIt's the most common now for anyone not willing to be on a loooong Suporn list. It's not "more natural" but it has way lower complication rates and it's also not very expensive.>Idk if being outside establishment trans means more openness to better but not traditional procedures.I honestly don't understand what you mean. PPT is available to anyone in or outside the "establishment trans" (whatever that means). However in Europe it's not covered by State insurance so ig from that perspective it's wealthier trannies and people like me who access it.
>pushing 30>still confused about sexuality and gender identity because every time I think I understand it, someone tells me I'm wrong and a Bad PersonI can't help that I'm weird. If I'm not hurting anyone and want to self-actualize, is it really such a sin to try to have a foundation for understanding myself?
>>44448555You’re fine you’re just honest. Everyone else is the same they are just very protective of their headcanon because it’s integral to their own attempts at self actualisation and they lack the self awareness to be analytical or introspective about it.
>>44448555No, it's not wrong. Don't let others be a barrier to your happiness.
>>44448583That makes sense I suppose, but unfortunately brings me no closer to understanding myself. >>44448610I've done nothing but let that happen, even if unconsciously. Every time I try to pursue my own happiness I wind up being punished for my hubris.
same desu
go ahead make fun of pooners again
>>44443827You’re incorrect. “The eyes” is a result of a lack of supraorbital projection
>>44443862Those lines are called the vagina bones I’ve heard
>>44443798Huge rack for sucking on while plamming his pussy and jerking off his huge clit
>>44443798once i do meet a pooner i will as you requested so that he can hit me and deman me and choke me and hold me during our hot wholesome t4t seggs
>>44443798Oh whatever he's soft mentally and probably 5'2", I'll just knock him over and prepare him for motherhood
https://annelawrence.com/wp-content/uploads/2023/12/Lawrence-2013-men-trapped-in-mens-bodies-book.pdfhttps://faculty.wcas.northwestern.edu/JMichael-Bailey/autogynephilia.htm#:~:text=Blanchard%20believes%20that%20autogynephilia%20is,self)%20rather%20than%20the%20outside.here are two of some resources ive read and alongside realizing i had the most AGP coded memory from when i was 5 years old i just came to the conclusion that yeah i actually am a real AGPis anyone else here also an actual AGP also trooning out cuz YOLO
>>44444138We do have some similarities, but as I see it, I'm far more like a gay man than you. Mt best relationships were with gay men and I really don't want to be a woman, as much as I would like to be a really pretty feminine gay boy, who looks like a woman. I love being extremely feminine in personality.I don't want to have the periods or large breasts most women have, especially when they get older.. I don't want to have that kind of body. I also like my dick and I like having sex with it. I guess I wish gay men were more heteronormative?
>>44444310>>44444319Nothing I'm saying is taken from Blanchard and I'm not even sure if I have AGP. The only thing I'm sure about is that most gay men do not transition and maybe I shouldn't have
>>44441886Autogynephilia is the oroboros snake eating itself alive.
>>44446903What a cursed sexuality to be born with
I don't visit this board enough to keep up with lingo, can someone please break down the terminology and discourse over AGP and related terms?I know it stands for autogynephilia, and that it was pushed erroneously as the idea that transgender women are sexually aroused by being women, but that's about itSurely SOME people get off on being seen as/acting feminine even if it's not the majority, right?
its crazy how some men get to look like this for free while the rest are doomed to look like an ogre for eternity
>>44448438I want an ass like this >>44444743>>44443976not a chopped man body
>>44448438where is it where is your muscle ass
>>44448968yes i love man ass
>>44446239Wahhh>>44446506>third world nigger
>>44446940Not everyone has dysphoria surrounding their genitals. I personally don't mind my penis so long as it doesn't get erect, and luckily, HRT mostly stopped that.As for the thirst traps, we're just enjoying being women. Cis women do the exact same thing.
I don't know if it's just an AO3 thing but what cis man gets mad about rejection then writes detrans fakeboy kink shit where the guy who rejected him is a minor that gets raped and killed, then actually jerks off to itالله سبحنه وتعالى اقتل هذا الشيطان سيسجندرالله سبحنه وتعالى اقتل هذا الشيطان سيسجندرالله سبحنه وتعالى اقتل هذا الشيطان سيسجندر
>>44450071stop reminding me of him oh my god please he is still trying to contact me to this day im not trying to think about him while I jerk my clit to horny threads in here
>>44450133Holy Shit no way that's youالله سبحنه وتعالى حفظ عل المتحولين والمتحولات
>>44450153hes actually written worse and sent it to me ill get scs tomorrow too lazy rn
>>44450169I would send a few more prayers your way but my Arabic is giving up and I'm a little tired of larping as MuslimWill be checking in
can't even refresh this board without seeing hastag them god just strike me down already I do not want to remember he exists
>>44450109who
>>44450170Judging by what looks like Fukase it's about this guy that wrote an ao3 detrans fanfic since someone made a thread about it like right before this one
i dont like it when i see racism and homophobia, people being mean for no reason etc how do i stop caring about that
>>44448990Yes you are. You just don’t want to admit that the idea I mentioned is super intriguing to you.
>>44448989im a cis bi man but i strongly dislike bad stuffi know we're all humans with jobs, lives, and families but idk i just really dont like some people
>>44448997>>44448997because its about "tcd" which is just hating another group.i know that some cis are bad but wtf cmon>>44449000im not youre a groomer
bump
>>44448893Make yerself deafThen blind yerselfFinally, stab yer brocea center
